Targeted drug delivery to the brain and brain tumors using focused ultrasound and microbubbles

2013 ◽  
Vol 134 (5) ◽  
pp. 4089-4089 ◽  
Author(s):  
Nathan McDannold
Keyword(s):  
Drug Delivery ◽  
Brain Tumors ◽  
Targeted Drug Delivery ◽  
Focused Ultrasound ◽  
Targeted Drug ◽  
The Brain

scholarly journals An update of nanoparticle-based approaches for glioblastoma multiforme immunotherapy

Nanomedicine ◽  
2020 ◽  
Vol 15 (19) ◽  
pp. 1861-1871
Author(s):  
Lorenzo Taiarol ◽  
Beatrice Formicola ◽  
Roberta Dal Magro ◽  
Silvia Sesana ◽  
Francesca Re
Keyword(s):  
Drug Delivery ◽  
Glioblastoma Multiforme ◽  
Adverse Effects ◽  
Brain Tumors ◽  
Nucleic Acids ◽  
Targeted Drug Delivery ◽  
The Past ◽  
Targeted Drug ◽  
The Brain ◽  
Made In

Glioblastoma multiforme is a serious medical issue in the brain oncology field due to its aggressiveness and recurrence. Immunotherapy has emerged as a valid approach to counteract the growth and metastasization of glioblastoma multiforme. Among the different innovative approaches investigated, nanoparticles gain attention because of their versatility which is key in allowing precise targeting of brain tumors and increasing targeted drug delivery to the brain, thus minimizing adverse effects. This article reviews the progress made in this field over the past 2 years, focusing on nonspherical and biomimetic particles and on vectors for the delivery of nucleic acids. However, challenges still need to be addressed, considering the improvement of the particles passage across the blood–meningeal barrier and/or the blood–brain barrier, promoting the clinical translatability of these approaches.

Recent Advances in Targeted Drug Delivery Approaches using Lipidic and Polymeric Nanocarriers for the management of Alzheimer’s Disease

2021 ◽  
Vol 27 ◽  
Author(s):  
Dhara Lakdawala ◽  
Md Abdur Rashid ◽  
Farhan Jalees Ahmad
Keyword(s):  
Alzheimer’S Disease ◽  
Drug Delivery ◽  
Alzheimer's Disease ◽  
Blood Brain Barrier ◽  
Targeted Drug Delivery ◽  
Brain Barrier ◽  
Polymeric Nanocarriers ◽  
Blood Brain ◽  
Targeted Drug ◽  
The Brain

: Drug delivery to the brain has remained a significant challenge in treating neurodegenerative disorders such as Alzheimer's disease due to the presence of the blood-brain barrier, which primarily obstructs the access of drugs and biomolecules into the brain. Several methods to overcome the blood-brain barrier have been employed, such as chemical disruption, surgical intervention, focused ultrasound, intranasal delivery and using nanocarriers. Nanocarrier systems remain the method of choice and have shown promising results over the past decade to achieve better drug targeting. Polymeric nanocarriers and lipidic nanoparticles act as a carrier system providing better encapsulation of drugs, site-specific delivery, increased bioavailability and sustained release of drugs. The surface modifications and functionalization of these nanocarrier systems have greatly facilitated targeted drug delivery. The safety and efficacy of these nanocarrier systems have been ascertained by several in vitro and in vivo models. In the present review, we have elaborated on recent developments of nanoparticles as a drug delivery system for Alzheimer's disease, explicitly focusing on polymeric and lipidic nanoparticles.

scholarly journals Macrophages with cellular backpacks for targeted drug delivery to the brain

Biomaterials ◽  
2017 ◽  
Vol 140 ◽  
pp. 79-87 ◽  
Author(s):  
Natalia L. Klyachko ◽  
Roberta Polak ◽  
Matthew J. Haney ◽  
Yuling Zhao ◽  
Reginaldo J. Gomes Neto ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Targeted Drug ◽  
The Brain
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