The effect of surfactants on inertial cavitation activity and sonoluminescence intensity in aqueous solutions

2004 ◽  
Vol 116 (4) ◽  
pp. 2541-2541
Author(s):  
Muthupandian Ashokkumar ◽  
Judy Lee ◽  
Sandra Kentish ◽  
Franz Grieser ◽  
Thomas J. Matula
Keyword(s):  
Aqueous Solutions ◽  
Inertial Cavitation ◽  
Cavitation Activity

scholarly journals Investigation of the Inertial Cavitation Activity of Sonosensitive and Biocompatible Nanoparticles for Drug Delivery Applications Employing High Intensity Focused Ultrasound

2019 ◽  
Vol 5 (1) ◽  
pp. 585-588
Author(s):  
Benedikt George ◽  
Michael Fink ◽  
Helmut Ermert ◽  
Stefan J. Rupitsch ◽  
Pia T. Hiltl ◽  
...  
Keyword(s):  
Drug Release ◽  
High Intensity ◽  
Focused Ultrasound ◽  
Active Drug ◽  
Drug Carriers ◽  
High Intensity Focused Ultrasound ◽  
Activity Level ◽  
Inertial Cavitation ◽  
Cavitation Effect ◽  
Cavitation Activity

AbstractAn approach to improve chemotherapy, while minimizing side effects, is a local drug release close to the tumorous tissue. For this purpose, the active drug component is often bound to nanoparticles employed as drug carriers. In the present study, we investigate sonosensitive, biocompatible poly-(L)-lactic acid (PLA) nanoparticles, which shall be used as drug carriers. For drug release, High Intensity Focused Ultrasound (HIFU) will be employed to introduce inertial cavitation, which separates the active drug component from the drug carrier. The cavitation effect generates an acoustic noise signal, which characterizes the cavitation activity and is expected to serve simultaneously as an indicator for the release of the active drug component. Depending on the ultrasound frequency, different acoustic levels of the inertial cavitation activity were measured. Investigations using a setup for passive cavitation detection (PCD) deliver quantitative results regarding the frequency dependence of the cavitation activity level of nanoparticles and reference media.

scholarly journals Evaluation of inertial cavitation activity in tissue through measurement of oxidative stress

2015 ◽  
Vol 26 ◽  
pp. 193-199 ◽  
Author(s):  
Fabrice Prieur ◽  
Vincent Pialoux ◽  
Jean-Louis Mestas ◽  
Pauline Mury ◽  
Sarah Skinner ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Inertial Cavitation ◽  
Cavitation Activity

Towards a standardized approach for quantifying inertial cavitation activity

2008 ◽  
Vol 123 (5) ◽  
pp. 3004-3004
Author(s):  
Jamie R. Collin ◽  
Ian Webb ◽  
Ronald A. Roy ◽  
Constantin C. Coussios
Keyword(s):  
Inertial Cavitation ◽  
Cavitation Activity

Effect of high intensity focused ultrasound transducer F-number and waveform non-linearity on inertial cavitation activity

2018 ◽  
Vol 144 (3) ◽  
pp. 1824-1824 ◽  
Author(s):  
Christopher Bawiec ◽  
Christopher Hunter ◽  
Wayne Kreider ◽  
Adam D. Maxwell ◽  
Vera A. Khokhlova ◽  
...  
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Ultrasound Transducer ◽  
Inertial Cavitation ◽  
Cavitation Activity

scholarly journals Intracranial inertial cavitation threshold and thermal ablation lesion creation using MRI-guided 220-kHz focused ultrasound surgery: preclinical investigation

2015 ◽  
Vol 122 (1) ◽  
pp. 152-161 ◽  
Author(s):  
Zhiyuan Xu ◽  
Carissa Carlson ◽  
John Snell ◽  
Matt Eames ◽  
Arik Hananel ◽  
...  
Keyword(s):  
Low Power ◽  
Thermal Ablation ◽  
Focused Ultrasound ◽  
Acoustic Energy ◽  
Thermal Lesion ◽  
Ischemic Infarction ◽  
Inertial Cavitation ◽  
Long Duration ◽  
Mri Guided ◽  
Cavitation Activity

OBJECT In biological tissues, it is known that the creation of gas bubbles (cavitation) during ultrasound exposure is more likely to occur at lower rather than higher frequencies. Upon collapsing, such bubbles can induce hemorrhage. Thus, acoustic inertial cavitation secondary to a 220-kHz MRI-guided focused ultrasound (MRgFUS) surgery is a serious safety issue, and animal studies are mandatory for laying the groundwork for the use of low-frequency systems in future clinical trials. The authors investigate here the in vivo potential thresholds of MRgFUS-induced inertial cavitation and MRgFUS-induced thermal coagulation using MRI, acoustic spectroscopy, and histology. METHODS Ten female piglets that had undergone a craniectomy were sonicated using a 220-kHz transcranial MRgFUS system over an acoustic energy range of 5600–14,000 J. For each piglet, a long-duration sonication (40-second duration) was performed on the right thalamus, and a short sonication (20-second duration) was performed on the left thalamus. An acoustic power range of 140–300 W was used for long-duration sonications and 300–700 W for short-duration sonications. Signals collected by 2 passive cavitation detectors were stored in memory during each sonication, and any subsequent cavitation activity was integrated within the bandwidth of the detectors. Real-time 2D MR thermometry was performed during the sonications. T1-weighted, T2-weighted, gradient-recalled echo, and diffusion-weighted imaging MRI was performed after treatment to assess the lesions. The piglets were killed immediately after the last series of posttreatment MR images were obtained. Their brains were harvested, and histological examinations were then performed to further evaluate the lesions. RESULTS Two types of lesions were induced: thermal ablation lesions, as evidenced by an acute ischemic infarction on MRI and histology, and hemorrhagic lesions, associated with inertial cavitation. Passive cavitation signals exhibited 3 main patterns identified as follows: no cavitation, stable cavitation, and inertial cavitation. Low-power and longer sonications induced only thermal lesions, with a peak temperature threshold for lesioning of 53°C. Hemorrhagic lesions occurred only with high-power and shorter sonications. The sizes of the hemorrhages measured on macroscopic histological examinations correlated with the intensity of the cavitation activity (R2 = 0.74). The acoustic cavitation activity detected by the passive cavitation detectors exhibited a threshold of 0.09 V·Hz for the occurrence of hemorrhages. CONCLUSIONS This work demonstrates that 220-kHz ultrasound is capable of inducing a thermal lesion in the brain of living swines without hemorrhage. Although the same acoustic energy can induce either a hemorrhage or a thermal lesion, it seems that low-power, long-duration sonication is less likely to cause hemorrhage and may be safer. Although further study is needed to decrease the likelihood of ischemic infarction associated with the 220-kHz ultrasound, the threshold established in this work may allow for the detection and prevention of deleterious cavitations.

Intravascular inertial cavitation activity detection and quantification in vivo with Optison

2006 ◽  
Vol 32 (10) ◽  
pp. 1601-1609 ◽  
Author(s):  
Juan Tu ◽  
Joo Ha Hwang ◽  
Thomas J. Matula ◽  
Andrew A. Brayman ◽  
Lawrence A. Crum
Keyword(s):  
Activity Detection ◽  
Inertial Cavitation ◽  
Cavitation Activity ◽  
Detection And Quantification

Dependence of inertial cavitation activity on the high intensity focused ultrasound transducer F-number

2016 ◽  
Vol 140 (4) ◽  
pp. 2983-2983
Author(s):  
Tatiana Khokhlova ◽  
Christopher Hunter ◽  
Wayne Kreider ◽  
Adam Maxwell ◽  
Vera Khokhlova ◽  
...  
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Ultrasound Transducer ◽  
Inertial Cavitation ◽  
Cavitation Activity

scholarly journals In VitroDemonstration of Focused Ultrasound Thrombolysis Using Bifrequency Excitation

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Izella Saletes ◽  
Bruno Gilles ◽  
Vincent Auboiroux ◽  
Nadia Bendridi ◽  
Rares Salomir ◽  
...  
Keyword(s):  
Thermal Effects ◽  
Focused Ultrasound ◽  
Power Level ◽  
Pharmacological Agent ◽  
Inertial Cavitation ◽  
Blood Clots ◽  
Before And After ◽  
Passive Acoustic ◽  
Cavitation Activity

Focused ultrasound involving inertial cavitation has been shown to be an efficient method to induce thrombolysis without any pharmacological agent. However, further investigation of the mechanisms involved and further optimization of the process are still required. The present work aims at studying the relevance of a bifrequency excitation compared to a classical monofrequency excitation to achieve thrombolysis without any pharmacological agent.In vitrohuman blood clots were placed at the focus of a piezoelectric transducer. Efficiency of the thrombolysis was assessed by weighing each clot before and after sonication. The efficiencies of mono- (550 kHz) and bifrequency (535 and 565 kHz) excitations were compared for peak power ranging from 70 W to 220 W. The thrombolysis efficiency appears to be correlated to the inertial cavitation activity quantified by passive acoustic listening. In the conditions of the experiment, the power needed to achieve 80% of thrombolysis with a monofrequency excitation is reduced by the half with a bifrequency excitation. The thermal effects of bifrequency and monofrequency excitations, studied using MR thermometry measurements in turkey muscle samples where no cavitation occurred, did not show any difference between both types of excitations when using the same power level.

scholarly journals Hysteresis of inertial cavitation activity induced by fluctuating bubble size distribution

2015 ◽  
Vol 27 ◽  
pp. 262-267 ◽  
Author(s):  
Pauline Muleki Seya ◽  
Cyril Desjouy ◽  
Jean-Christophe Béra ◽  
Claude Inserra
Keyword(s):  
Size Distribution ◽  
Bubble Size ◽  
Bubble Size Distribution ◽  
Inertial Cavitation ◽  
Cavitation Activity
Sign in / Sign up

Export Citation Format

Share Document