Confocal imaging of sensory organ formation during Xenopus inner ear development

2001 ◽  
Vol 109 (5) ◽  
pp. 2357-2357
Author(s):  
Elba E. Serrano ◽  
Quincy A. Quick
Keyword(s):  
Inner Ear ◽  
Confocal Imaging ◽  
Sensory Organ ◽  
Ear Development ◽  
Organ Formation ◽  
Inner Ear Development

Comparative analysis of conservation and regulatory network on core transcription factors in mouse inner ear development

2013 ◽  
Vol 35 (10) ◽  
pp. 1198-1208
Author(s):  
Zhi-Qiang CHEN ◽  
Xin-Huan HAN ◽  
Qin-Jun WEI ◽  
Guang-Qian XING ◽  
Xin CAO
Keyword(s):  
Transcription Factors ◽  
Comparative Analysis ◽  
Inner Ear ◽  
Regulatory Network ◽  
Ear Development ◽  
Inner Ear Development

scholarly journals Residual microRNA expression dictates the extent of inner ear development in conditional Dicer knockout mice

2009 ◽  
Vol 328 (2) ◽  
pp. 328-341 ◽  
Author(s):  
Garrett A. Soukup ◽  
Bernd Fritzsch ◽  
Marsha L. Pierce ◽  
Michael D. Weston ◽  
Israt Jahan ◽  
...  
Keyword(s):  
Inner Ear ◽  
Knockout Mice ◽  
Microrna Expression ◽  
Ear Development ◽  
Inner Ear Development

scholarly journals Role of microRNAs in inner ear development and hearing loss

Gene ◽  
2019 ◽  
Vol 686 ◽  
pp. 49-55 ◽  
Author(s):  
Rahul Mittal ◽  
George Liu ◽  
Sai P. Polineni ◽  
Nicole Bencie ◽  
Denise Yan ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Inner Ear ◽  
Ear Development ◽  
Inner Ear Development

Axial specification for sensory organs versus non-sensory structures of the chicken inner ear

Development ◽  
1998 ◽  
Vol 125 (1) ◽  
pp. 11-20 ◽  
Author(s):  
D.K. Wu ◽  
F.D. Nunes ◽  
D. Choo
Keyword(s):  
Gene Expression ◽  
Inner Ear ◽  
Expression Patterns ◽  
Growth Factor Receptor ◽  
Gross Anatomy ◽  
Sensory Organ ◽  
Sensory Organs ◽  
Organ Formation ◽  
Sensory Structures ◽  
Axial Specification

A mature inner ear is a complex labyrinth containing multiple sensory organs and nonsensory structures in a fixed configuration. Any perturbation in the structure of the labyrinth will undoubtedly lead to functional deficits. Therefore, it is important to understand molecularly how and when the position of each inner ear component is determined during development. To address this issue, each axis of the otocyst (embryonic day 2.5, E2.5, stage 16–17) was changed systematically at an age when axial information of the inner ear is predicted to be fixed based on gene expression patterns. Transplanted inner ears were analyzed at E4.5 for gene expression of BMP4 (bone morphogenetic protein), SOHo-1 (sensory organ homeobox-1), Otx1 (cognate of Drosophila orthodenticle gene), p75NGFR (nerve growth factor receptor) and Msx1 (muscle segment homeobox), or at E9 for their gross anatomy and sensory organ formation. Our results showed that axial specification in the chick inner ear occurs later than expected and patterning of sensory organs in the inner ear was first specified along the anterior/posterior (A/P) axis, followed by the dorsal/ventral (D/V) axis. Whereas the A/P axis of the sensory organs was fixed at the time of transplantation, the A/P axis for most non-sensory structures was not and was able to be re-specified according to the new axial information from the host. The D/V axis for the inner ear was not fixed at the time of transplantation. The asynchronous specification of the A/P and D/V axes of the chick inner ear suggests that sensory organ formation is a multi-step phenomenon, rather than a single inductive event.

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