The impact of microbubbles on measurement of drug release from echogenic liposomes

2012 ◽  
Vol 131 (4) ◽  
pp. 3246-3246
Author(s):  
Jonathan Kopechek ◽  
Kevin Haworth ◽  
Kirthi Radhakrishnan ◽  
Shaoling Huang ◽  
Melvin Klegerman ◽  
...  
Keyword(s):  
Drug Release ◽  
Echogenic Liposomes ◽  
The Impact

scholarly journals The impact of bubbles on measurement of drug release from echogenic liposomes

2013 ◽  
Vol 20 (4) ◽  
pp. 1121-1130 ◽  
Author(s):  
Jonathan A. Kopechek ◽  
Kevin J. Haworth ◽  
Kirthi Radhakrishnan ◽  
Shao-Ling Huang ◽  
Melvin E. Klegerman ◽  
...  
Keyword(s):  
Drug Release ◽  
Echogenic Liposomes ◽  
The Impact

scholarly journals The Impact of Gelatin on the Pharmaceutical Characteristics of Fucoidan Microspheres with Posaconazole

Materials ◽  
2021 ◽  
Vol 14 (15) ◽  
pp. 4087
Author(s):  
Marta Szekalska ◽  
Aleksandra Citkowska ◽  
Magdalena Wróblewska ◽  
Katarzyna Winnicka
Keyword(s):  
Antifungal Activity ◽  
Drug Release ◽  
Spray Drying ◽  
Fungal Infections ◽  
Drug Loading ◽  
High Surface ◽  
Vaginal Fluid ◽  
Sustained Drug Release ◽  
Candida Spp ◽  
The Impact

Fungal infections and invasive mycoses, despite the continuous medicine progress, are an important globally therapeutic problem. Multicompartment dosage formulations (e.g., microparticles) ensure a short drug diffusion way and high surface area of drug release, which as a consequence can provide improvement of therapeutic efficiency compared to the traditional drug dosage forms. As fucoidan is promising component with wide biological activity per se, the aim of this study was to prepare fucospheres (fucoidan microparticles) and fucoidan/gelatin microparticles with posaconazole using the one-step spray-drying technique. Pharmaceutical properties of designed fucospheres and the impact of the gelatin addition on their characteristics were evaluated. An important stage of this research was in vitro evaluation of antifungal activity of developed microparticles using different Candida species. It was observed that gelatin presence in microparticles significantly improved swelling capacity and mucoadhesiveness, and provided a sustained POS release. Furthermore, it was shown that gelatin addition enhanced antifungal activity of microparticles against tested Candida spp. strains. Microparticles formulation GF6, prepared by the spray drying of 20% fucoidan, 5% gelatin and 10% Posaconazole, were characterized by optimal mucoadhesive properties, high drug loading and the most sustained drug release (after 8 h 65.34 ± 4.10% and 33.81 ± 5.58% of posaconazole was dissolved in simulated vaginal fluid pH 4.2 or 0.1 M HCl pH 1.2, respectively).

scholarly journals The Correlation between Physical Crosslinking and Water-Soluble Drug Release from Chitosan-Based Microparticles

Pharmaceutics ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 455
Author(s):  
Emilia Szymańska ◽  
Katarzyna Woś-Latosi ◽  
Julia Jacyna ◽  
Magdalena Dąbrowska ◽  
Joanna Potaś ◽  
...  
Keyword(s):  
Drug Release ◽  
Polymer Matrix ◽  
Drug Loading ◽  
Water Soluble ◽  
Dissolution Behavior ◽  
Complex Nature ◽  
Prolonged Release ◽  
Scanning Calorimetry ◽  
Burst Effect ◽  
The Impact

Microparticles containing water-soluble zidovudine were prepared by spray-drying using chitosan glutamate and beta-glycerophosphate as an ion crosslinker (CF). The Box–Behnken design was applied to optimize the microparticles in terms of their drug loading and release behavior. Physicochemical studies were undertaken to support the results from dissolution tests and to evaluate the impact of the crosslinking ratio on the microparticles’ characteristics. The zidovudine dissolution behavior had a complex nature which comprised two phases: an initial burst effect followed with a prolonged release stage. The initial drug release, which can be modulated by the crosslinking degree, was primarily governed by the dissolution of the drug crystals located on the microparticles’ surfaces. In turn, the further dissolution stage was related to the drug diffusion from the swollen polymer matrix and was found to correlate with the drug loading. Differential Scanning Calorimetry (DSC) studies revealed the partial incorporation of a non-crystallized drug within the polymer matrix, which correlated with the amount of CF. Although CF influenced the swelling capacity of chitosan glutamate microparticles, surprisingly a higher amount of CF did not impact the time required for 80% of the drug to be released markedly. The formulation with the lowest polymer:CF ratio, 3:1, was selected as optimal, providing satisfactory drug loading and displaying a moderate burst effect within the first 30 min of the study, followed with a prolonged drug release of up to 210 min.

A study of the impact of excipient shielding on initial drug release using UV imaging

2018 ◽  
Vol 553 (1-2) ◽  
pp. 229-237 ◽  
Author(s):  
Tze Ning Hiew ◽  
Muhammad Ismail Bin Alaudin ◽  
Siang Meng Chua ◽  
Paul Wan Sia Heng
Keyword(s):  
Drug Release ◽  
Uv Imaging ◽  
The Impact ◽  
Initial Drug

scholarly journals Tuneable spheroidal hydrogel particles for cell and drug encapsulation

Soft Matter ◽  
2018 ◽  
Vol 14 (27) ◽  
pp. 5622-5627 ◽  
Author(s):  
Isabel M. Bjørge ◽  
Ana M. S. Costa ◽  
A. Sofia Silva ◽  
João P. O. Vidal ◽  
J. Miguel Nóbrega ◽  
...  
Keyword(s):  
Drug Release ◽  
Release Kinetics ◽  
Cell Encapsulation ◽  
Drug Encapsulation ◽  
Drug Release Kinetics ◽  
Hydrogel Particles ◽  
The Impact

Straight-forward production of spheroidal particles allows the assessment of the impact of geometry on cell encapsulation viability and drug release kinetics.

scholarly journals Comparison of Rheological, Drug Release, and Mucoadhesive Characteristics upon Storage between Hydrogels with Unmodified or Beta-Glycerophosphate-Crosslinked Chitosan

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Emilia Szymańska ◽  
Anna Czajkowska-Kośnik ◽  
Katarzyna Winnicka
Keyword(s):  
Drug Release ◽  
Ex Vivo ◽  
Physicochemical Characteristics ◽  
Vaginal Mucosa ◽  
Drug Release Profile ◽  
Modified Chitosan ◽  
Long Term Storage ◽  
Crosslinked Chitosan ◽  
Chitosan Hydrogels ◽  
The Impact

The physicochemical characteristics of beta-glycerophosphate-crosslinked chitosan hydrogels were investigated upon long-term storage at ambient, accelerated, and refrigerated conditions and compared to unmodified chitosan formulations. Additionally, the impact of chitosan modification on the ex vivo mucoadhesive performance in contact with porcine vaginal mucosa and on the drug release profile from hydrogels was evaluated. Viscosity and mechanical properties of formulations with unmodified chitosan decreased significantly upon storage regardless of tested conditions as a result of hydrolytic depolymerization. Introduction of ion crosslinker exerted stabilizing effect on physicochemical performance of chitosan hydrogels but only upon storage at refrigerated conditions. Beta-glycerophosphate-modified chitosan formulations preserved organoleptic, rheological behavior, and hydrogel structure up to 3-month storage at 4 ± 2°C. Viscosity variations upon storage influenced markedly mucoadhesive properties and drug release rate from hydrogels.

Formulation and Characterization of Thermoplastic Polyurethane-Based Steroid Eluting Devices

2019 ◽  
Author(s):  
Jessica Doan ◽  
Peter Phommahaxay ◽  
Sarah Olson ◽  
Matthew A. Petersen
Keyword(s):  
Drug Release ◽  
Medical Devices ◽  
Thermoplastic Polyurethane ◽  
Release Behavior ◽  
Implantable Medical Devices ◽  
Industry Standard ◽  
Rapid Characterization ◽  
The Impact ◽  
Standard Components

We describe the formulation and manufacture of thermoplastic polyurethane (TPU)-based steroid-eluting components and the development of a versatile, material-agnostic analytical method for their rapid characterization. The impact of materials, formulation, and processing on controlled release behavior was characterized and compared to current industry standard components under physiologically relevant conditions. The combination of factors modulated drug release, offering new avenues for controlling the release of steroids from implantable medical devices.

Relationship between cavitation, rapid loss of echogenicity, and drug release from echogenic liposomes.

2010 ◽  
Vol 127 (3) ◽  
pp. 1976-1976
Author(s):  
Kirthi Radhakrishnan ◽  
Jonathan A. Kopechek ◽  
Kevin J. Haworth ◽  
Shaoling Huang ◽  
David D. McPherson ◽  
...  
Keyword(s):  
Drug Release ◽  
Rapid Loss ◽  
Echogenic Liposomes
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