Contralateral suppression of transiently evoked otoacoustic emissions by harmonic complex tones in humans

1999 ◽  
Vol 105 (1) ◽  
pp. 293-305 ◽  
Author(s):  
Christophe Micheyl ◽  
Stéphane Maison ◽  
Robert P. Carlyon ◽  
Guillaume Andéol ◽  
Lionel Collet
Keyword(s):  
Otoacoustic Emissions ◽  
Harmonic Complex ◽  
Contralateral Suppression ◽  
Complex Tones ◽  
Transiently Evoked Otoacoustic Emissions

Absence of contralateral suppression of transiently evoked otoacoustic emissions in fibromyalgia syndrome

2008 ◽  
Vol 122 (10) ◽  
pp. 1047-1051 ◽  
Author(s):  
B Gunduz ◽  
Y A Bayazit ◽  
F Celenk ◽  
C Sarıdoğan ◽  
A G Guclu ◽  
...  
Keyword(s):  
Otoacoustic Emissions ◽  
Pure Tone ◽  
Fibromyalgia Syndrome ◽  
Pure Tone Audiometry ◽  
Otoacoustic Emission ◽  
Normal Hearing ◽  
Superior Olivary Complex ◽  
Contralateral Suppression ◽  
The Mean ◽  
Transiently Evoked Otoacoustic Emissions

AbstractObjective:To assess contralateral suppression of transiently evoked otoacoustic emissions in patients with fibromyalgia syndrome and normal hearing.Methods:Twenty-four female patients with fibromyalgia syndrome and 24 healthy female controls with normal hearing were assessed using pure tone audiometry and transiently evoked otoacoustic emissions.Results:All patients with fibromyalgia syndrome and all controls had normal hearing on pure tone audiometry. In the patients with fibromyalgia syndrome, the mean transiently evoked otoacoustic emission amplitude was 15.5 ± 4.8 dB. The mean transiently evoked otoacoustic emission amplitudes after contralateral suppression was 15.5 ± 4.9 dB. There was no statistically significant difference between the transiently evoked otoacoustic emission amplitudes measured before and after contralateral suppression (p > 0.05). In the controls, the mean transiently evoked otoacoustic emission amplitude was 12 ± 5 dB. The mean transiently evoked otoacoustic emission amplitudes after contralateral suppression was 11 ± 4.7 dB. There was a statistically significant decrease in transiently evoked otoacoustic emission amplitudes after contralateral suppression (p < 0.01).Conclusion:The mechanisms related to contralateral suppression of transiently evoked otoacoustic emissions seem dysfunctional in fibromyalgia syndrome. This dysfunction may be at the brain stem level, where the medial superior olivary complex is located, or at the synapses of medial superior olivary complex fibres with the outer hair cells in the cochlea. Demonstration of lack of contralateral suppression of transiently evoked otoacoustic emissions can be used as a diagnostic tool in patients with fibromyalgia syndrome.

Effect of topically applied povidone-iodine on transient evoked otoacoustic emissions in guinea pigs

2003 ◽  
Vol 117 (9) ◽  
pp. 700-703 ◽  
Author(s):  
Recep Yagiz ◽  
Abdullah Tas ◽  
Cem Uzun ◽  
Mustafa Kemal Adali ◽  
Muhsin Koten ◽  
...  
Keyword(s):  
Middle Ear ◽  
Guinea Pigs ◽  
Otoacoustic Emissions ◽  
Povidone Iodine ◽  
Positive Control ◽  
Middle Ear Surgery ◽  
Iodine Solution ◽  
Before And After ◽  
Transiently Evoked Otoacoustic Emissions ◽  
Povidone Iodine Solution

The possible cochlear toxicity of topically applied povidone-iodine solution was investigated in guinea pigs by measuring transiently evoked otoacoustic emissions (TEOAEs). Seven adult pigmented guinea pigs (14 ears) with a normal acoustic pinna reflex were used. After the baseline TEOAE measurements, 0.1mL of povidone-iodine solution was applied transtympanically into the middle ear in the study group. Saline solution and gentamicin were used as negative and positive control, respectively. TEOAE measurements were repeated on the 10th day, and four weeks after the first application. Tympanometric measurements were also carried out for both ears of all animals at the end of the study. Responses in all ears, which had povidone-iodine applied to them, disappeared in a way similar to those recorded in gentamicin-treated ears. Tympanometric measurements at the end of the study showed ’type A’ tympanograms in all ears of all animals. The present study showed that povidone-iodine could have a cochleotoxic effect in guinea pigs. A study in humans with TEOAE before and after middle-ear surgery, where povidone-iodine can reach into the middle-ear cavity, may be useful for evaluating this result for clinical practice.

Μελέτη των παραγόντων υψηλού κινδύνου για εμφάνιση βαρηκοΐας σε νεογνά της μονάδας εντατικής νοσηλείας

2016 ◽  
Author(s):  
Εμμανουήλ Νησωτάκης
Keyword(s):  
Otoacoustic Emissions ◽  
Auditory Brainstem ◽  
Auditory Brainstem Responses ◽  
Transiently Evoked Otoacoustic Emissions

Εισαγωγή Η συγγενής βαρηκοΐα είναι ίσως η πιο συχνή αισθητηριακή βλάβη της νεογνικής ηλικίας. Τα νοσηλευόμενα στη ΜΕΝΝ νεογνά θεωρείται ότι διατρέχουν μεγαλύτερο κίνδυνο για εμφάνιση είτε νευροαισθητήριας βαρηκοΐας είτε ακουστικής νευροπάθειας. Η σοβαρότητα της απώλειας ακοής κατά τη διάρκεια της πρώιμης κρίσιμης περιόδου ανάπτυξης του λόγου καθορίζει την απόκτηση επαρκούς γλωσσικής ικανότητας γι’ αυτό και είναι σημαντική η έγκαιρη διάγνωση και αντιμετώπιση κάθε υποκείμενης ακουστικής διαταραχής.Στη μελέτη αυτή εστιάζουμε στην παρουσία ακοολογικών παραγόντων κινδύνου και προσπαθούμε να διευκρινίσουμε την συσχέτισή τους με την εμφάνιση συγγενούς βαρηκοΐας, συμπεριλαμβανομένης και της ακουστικής νευροπάθειας, στον πληθυσμό των νεογνών της ΜΕΝΝ του νοσοκομείου μας.Ασθενείς και ΜέθοδοςΣτην παρούσα προοπτική μελέτη κοόρτης μελετήθηκαν 453 νεογνά τα οποία εισήχθησαν στη ΜΕΝΝ για περισσότερο από 24 ώρες μεταξύ 2012 και 2016 και εμφάνιζαν έναν ή περισσότερους παράγοντες κινδύνου. Όλα τα νεογνά υποβλήθηκαν σε ακοολογικό έλεγχο με χρήση αυτοματοποιημένων προκλητών δυναμικών του εγκεφαλικού στελέχους (automated Auditory Brainstem Responses – aABRs) σε συνδυασμό με παροδικά προκλητές ωτοακουστικές εκπομπές (Transiently Evoked OtoAcoustic Emissions – TEOAEs) τουλάχιστον 48 ώρες μετά τη γέννησή τους. Τα νεογνά που απέτυχαν στην αρχική εξέταση επανεξετάζονταν πριν τον πρώτο μήνα ζωής κι επί αποτυχίας παραπέμπονταν στο ιατρείο παιδικής βαρηκοΐας για πλήρη ακοολογικό έλεγχο. ΑποτελέσματαΑπό τον συνολικό αριθμό των 453 νεογνών 71 απέτυχαν στον αρχικό ακοολογικό έλεγχο. Μόνο 49 προσήλθαν για επανεξέταση και τελικά 8 νεογνά (1.8%) απέτυχαν τόσο στα a-ABRs όσο και στις TEOAEs και διαγνώσθηκαν με πιθανή νευροαισθητήρια βαρηκοΐα, ενώ σε επίσης 8 νεογνά (1.8%) οι TEOAEs εκλύθηκαν φυσιολογικά αλλά απέτυχαν στα a-ABRs οπότε διαγνώσθηκαν με πιθανή ακουστική νευροπάθεια. Από τους 13 ανεξάρτητους παράγοντες κινδύνου που ελέγχθηκαν η ωτοτοξικότητα των χορηγούμενων φαρμάκων, η μηχανική υποστήριξη της αναπνοής, το χαμηλό βάρος γέννησης και η υπερχολερυθριναιμία ήταν οι πιο συχνά εμφανιζόμενοι. Η πλειοψηφία των νεογνών (48%) εμφάνιζε ταυτόχρονα δύο παράγοντες κινδύνου. Το χαμηλό βάρος γέννησης βρέθηκε να συσχετίζεται με την εμφάνιση πιθανής νευροαισθητήριας βαρηκοΐας (p=0.002), ενώ οι κρανιοπροσωπικές ανωμαλίες και οι λοιμώξεις της ομάδας TORCH παρουσίασαν στατιστικά σημαντική συμμετοχή (p=0.03 και p=0.05 αντίστοιχα) στην ανάπτυξη πιθανής απώλειας ακοής συμπεριλαμβανομένης και της ακουστικής νευροπάθειας.ΣυμπεράσματαΤα προκλητά δυναμικά του εγκεφαλικού στελέχους (ABRs) και οι ωτοακουστικές εκπομπές (OAEs) αποτελούν τους θεμέλιους λίθους του καθολικού νεογνικού ελέγχου ακοής στη ΜΕΝΝ καθώς σημαντικός αριθμός παιδιών μπορεί να πάσχει από ακουστική νευροπάθεια. Η συνεχής επανεξέταση των παραγόντων κινδύνου και της συμβολής τους στην εμφάνιση βαρηκοΐας κρίνεται απαραίτητη καθώς αυτοί μεταβάλλονται. Απαιτείται ένα αποδοτικό σύστημα γραμματειακής υποστήριξης προκειμένου να ελαττωθεί το ποσοστό των νεογνών που δεν προσέρχονται για επανεξέταση.

Rabbits use both spectral and temporal cues to discriminate the fundamental frequency of harmonic complexes with missing fundamentals

2021 ◽  
Author(s):  
Joseph D Wagner ◽  
Alice Gelman ◽  
Kenneth E. Hancock ◽  
Yoojin Chung ◽  
Bertrand Delgutte
Keyword(s):  
Fundamental Frequency ◽  
Human Performance ◽  
Spectral Composition ◽  
Pitch Perception ◽  
Wide Frequency Range ◽  
Spatial Gradient ◽  
Harmonic Complex ◽  
Complex Tones ◽  
Behavioral Paradigm ◽  
Animal Vocalizations

The pitch of harmonic complex tones (HCT) common in speech, music and animal vocalizations plays a key role in the perceptual organization of sound. Unraveling the neural mechanisms of pitch perception requires animal models but little is known about complex pitch perception by animals, and some species appear to use different pitch mechanisms than humans. Here, we tested rabbits' ability to discriminate the fundamental frequency (F0) of HCTs with missing fundamentals using a behavioral paradigm inspired by foraging behavior in which rabbits learned to harness a spatial gradient in F0 to find the location of a virtual target within a room for a food reward. Rabbits were initially trained to discriminate HCTs with F0s in the range 400-800 Hz and with harmonics covering a wide frequency range (800-16,000 Hz), and then tested with stimuli differing either in spectral composition to test the role of harmonic resolvability (Experiment 1), or in F0 range (Experiment 2), or both F0 and spectral content (Experiment 3). Together, these experiments show that rabbits can discriminate HCTs over a wide F0 range (200-1600 Hz) encompassing the range of conspecific vocalizations, and can use either the spectral pattern of harmonics resolved by the cochlea for higher F0s or temporal envelope cues resulting from interaction between unresolved harmonics for lower F0s. The qualitative similarity of these results to human performance supports using rabbits as an animal model for studies of pitch mechanisms providing species differences in cochlear frequency selectivity and F0 range of vocalizations are taken into account.

Short-Term Test–Retest Reliability of Contralateral Suppression of Click-Evoked Otoacoustic Emissions in Normal-Hearing Subjects

2021 ◽  
pp. 1-11
Author(s):  
Hannah Keppler ◽  
Sofie Degeest ◽  
Bart Vinck
Keyword(s):  
Repeated Measures ◽  
Otoacoustic Emissions ◽  
Otoacoustic Emission ◽  
Normal Hearing ◽  
Short Term ◽  
Retest Reliability ◽  
Reliability Parameters ◽  
Contralateral Suppression ◽  
Short Term Test ◽  
Test Retest Reliability

Purpose The objective of the current study was to investigate the short-term test–retest reliability of contralateral suppression (CS) of click-evoked otoacoustic emissions (CEOAEs) using commercially available otoacoustic emission equipment. Method Twenty-three young normal-hearing subjects were tested. An otoscopic evaluation, admittance measures, pure-tone audiometry, measurements of CEOAEs without and with contralateral acoustic stimulation (CAS) to determine CS were performed at baseline ( n = 23), an immediate retest without and with refitting of the probe (only CS of CEOAEs; n = 11), and a retest after 1 week ( n = 23) were performed. Test–retest reliability parameters were determined on CEOAE response amplitudes without and with CAS, and on raw and normalized CS indices between baseline and the other test moments. Results Repeated-measures analysis of variance indicated no random or systematic changes in CEOAE response amplitudes without and with CAS, and in raw and normalized CS indices between the test moments. Moderate-to-high intraclass correlation coefficients with mostly high significant between-subjects variability between baseline and each consecutive test moment were found for CEOAE response amplitude without and with CAS, and for the raw and normalized CS indices. Other reliability parameters deteriorated between CEOAE response amplitudes with CAS as compared to without CAS, between baseline and retest with probe refitting, and after 1 week, as well as for frequency-specific raw and normalized CS indices as compared to global CS indices. Conclusions There was considerable variability in raw and normalized CS indices as measured using CEOAEs with CAS using commercially available otoacoustic emission equipment. More research is needed to optimize the measurement of CS of CEOAEs and to reduce influencing factors, as well as to make generalization of test–retest reliability data possible.

Contralateral suppression of otoacoustic emissions in a clinical sample of children with auditory processing disorder

2019 ◽  
Vol 58 (5) ◽  
pp. 301-310 ◽  
Author(s):  
Tone Stokkereit Mattsson ◽  
Ola Lind ◽  
Turid Follestad ◽  
Kjell Grøndahl ◽  
Wayne Wilson ◽  
...  
Keyword(s):  
Auditory Processing ◽  
Otoacoustic Emissions ◽  
Clinical Sample ◽  
Auditory Processing Disorder ◽  
Contralateral Suppression
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