Physiological control of sibilant duration: Insights afforded by speech compensation to dental prostheses

1979 ◽  
Vol 65 (5) ◽  
pp. 1276-1285 ◽  
Author(s):  
Sandra L. Hamlet ◽  
Bonita L. Cullison ◽  
Maureen L. Stone
Keyword(s):  
Physiological Control ◽  
Dental Prostheses

Control of Thrombin Mediated Cleavage of Protein S

1986 ◽  
Vol 56 (02) ◽  
pp. 151-154 ◽  
Author(s):  
Christina A Mitchell ◽  
Lena Hau ◽  
Hatem H Salem
Keyword(s):  
Anticoagulant Activity ◽  
Activated Protein C ◽  
Surface Protein ◽  
Protein S ◽  
Intact Protein ◽  
Control Mechanisms ◽  
Physiological Control ◽  
Endothelial Cell Surface ◽  
Thrombin Cleavage ◽  
Cofactor Activity

SummaryThrombin has been shown to cleave the vitamin K dependent cofactor protein S with subsequent loss of its cofactor activity. This study examines the control mechanisms for thrombin cleavage of protein S.The anticoagulant activity of activated protein C (APC) is enhanced fourteen fold by the addition of protein S. Thrombin cleaved protein S is seven fold less efficient than the native protein, and this loss of activity is due to reduced affinity of cleaved protein S for APC or the lipid surface compared to the intact protein.In the absence of Ca++, protein S is very sensitive to minimal concentrations of thrombin. As little as 1.5 nM thrombin results in complete cleavage of 20 nM protein S in 10 min and loss of cofactor activity. Ca++, in concentrations greater than 0.5 mM, will inhibit this cleavage and in the presence of physiological Ca++ concentrations, no cleavage of protein S could be demonstrated in spite of high concentrations of thrombin (up to 1 μM) and prolonged incubations (up to two hours). The endothelial surface protein thrombomodulin is very efficient in inhibiting the cleavage of protein S by thrombin suggesting that any thrombin formed on the endothelial cell surface is unlikely to cleave protein S, thus allowing the intact protein to act as a cofactor to APC.We conclude that the inhibitory effects of Ca++ and thrombomodulin on thrombin mediated cleavage of protein S imply that this event, by itself, is unlikely to represent a physiological control of the activity of protein S.

scholarly journals Stomatal conductance limited the CO2 response of grassland in the last century

BMC Biology ◽  
2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Juan C. Baca Cabrera ◽  
Regina T. Hirl ◽  
Rudi Schäufele ◽  
Andy Macdonald ◽  
Hans Schnyder
Keyword(s):  
Climate Change ◽  
Stomatal Conductance ◽  
Nitrogen Nutrition ◽  
Physiological Control ◽  
Co2 Response ◽  
Nitrogen Acquisition ◽  
Wide Range ◽  
Park Grass Experiment ◽  
Conductance Changes ◽  
Canopy Stomatal Conductance

Abstract Background The anthropogenic increase of atmospheric CO2 concentration (ca) is impacting carbon (C), water, and nitrogen (N) cycles in grassland and other terrestrial biomes. Plant canopy stomatal conductance is a key player in these coupled cycles: it is a physiological control of vegetation water use efficiency (the ratio of C gain by photosynthesis to water loss by transpiration), and it responds to photosynthetic activity, which is influenced by vegetation N status. It is unknown if the ca-increase and climate change over the last century have already affected canopy stomatal conductance and its links with C and N processes in grassland. Results Here, we assessed two independent proxies of (growing season-integrating canopy-scale) stomatal conductance changes over the last century: trends of δ18O in cellulose (δ18Ocellulose) in archived herbage from a wide range of grassland communities on the Park Grass Experiment at Rothamsted (U.K.) and changes of the ratio of yields to the CO2 concentration gradient between the atmosphere and the leaf internal gas space (ca – ci). The two proxies correlated closely (R2 = 0.70), in agreement with the hypothesis. In addition, the sensitivity of δ18Ocellulose changes to estimated stomatal conductance changes agreed broadly with published sensitivities across a range of contemporary field and controlled environment studies, further supporting the utility of δ18Ocellulose changes for historical reconstruction of stomatal conductance changes at Park Grass. Trends of δ18Ocellulose differed strongly between plots and indicated much greater reductions of stomatal conductance in grass-rich than dicot-rich communities. Reductions of stomatal conductance were connected with reductions of yield trends, nitrogen acquisition, and nitrogen nutrition index. Although all plots were nitrogen-limited or phosphorus- and nitrogen-co-limited to different degrees, long-term reductions of stomatal conductance were largely independent of fertilizer regimes and soil pH, except for nitrogen fertilizer supply which promoted the abundance of grasses. Conclusions Our data indicate that some types of temperate grassland may have attained saturation of C sink activity more than one century ago. Increasing N fertilizer supply may not be an effective climate change mitigation strategy in many grasslands, as it promotes the expansion of grasses at the disadvantage of the more CO2 responsive forbs and N-fixing legumes.

Influence of Heat Treatment on Dental Prostheses Produced by Additive Technology

2021 ◽  
Author(s):  
Viktoria Rajt'ukova ◽  
Lubos Chromy ◽  
Alena Findrik Balogova ◽  
Gabriela Izarikova ◽  
Andrea Sincak Konecna ◽  
...  
Keyword(s):  
Heat Treatment ◽  
Additive Technology ◽  
Dental Prostheses

scholarly journals Inlay-Retained Dental Bridges—A Finite Element Analysis

2021 ◽  
Vol 11 (9) ◽  
pp. 3770
Author(s):  
Monica Tatarciuc ◽  
George Alexandru Maftei ◽  
Anca Vitalariu ◽  
Ionut Luchian ◽  
Ioana Martu ◽  
...  
Keyword(s):  
Finite Element ◽  
Young Patients ◽  
Maximum Pressure ◽  
Class Iii ◽  
Element Analysis ◽  
Dental Prostheses ◽  
Abutment Teeth ◽  
Fixed Dental Prostheses ◽  
Implant Therapy ◽  
The Stability

Inlay-retained dental bridges can be a viable minimally invasive alternative when patients reject the idea of implant therapy or conventional retained full-coverage fixed dental prostheses, which require more tooth preparation. Inlay-retained dental bridges are indicated in patients with good oral hygiene, low susceptibility to caries, and a minimum coronal tooth height of 5 mm. The present study aims to evaluate, through the finite element method (FEM), the stability of these types of dental bridges and the stresses on the supporting teeth, under the action of masticatory forces. The analysis revealed the distribution of the load on the bridge elements and on the retainers, highlighting the areas of maximum pressure. The results of our study demonstrate that the stress determined by the loading force cannot cause damage to the prosthetic device or to abutment teeth. Thus, it can be considered an optimal economical solution for treating class III Kennedy edentation in young patients or as a provisional pre-implant rehabilitation option. However, special attention must be paid to its design, especially in the connection area between the bridge elements, because the connectors and the retainers represent the weakest parts.

Feasibility of 3D printed Co–Cr alloy for dental prostheses applications

2021 ◽  
Vol 862 ◽  
pp. 158171
Author(s):  
Anna Gabriella Camacho Presotto ◽  
Jairo Matozinho Cordeiro ◽  
João Gabriel Camacho Presotto ◽  
Elidiane Cipriano Rangel ◽  
Nilson Cristino da Cruz ◽  
...  
Keyword(s):  
Dental Prostheses ◽  
3D Printed
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