Ultrasound velocity in major bovine blood vessel walls

1978 ◽  
Vol 64 (2) ◽  
pp. 692-694 ◽  
Author(s):  
K. K. Shung ◽  
J. M. Reid
Keyword(s):  
Blood Vessel ◽  
Ultrasound Velocity ◽  
Bovine Blood ◽  
Vessel Walls

LEUKOTRIENES INDUCE THE ACUTE RELEASE OF TISSUE-TYPE PLASMINOGEN ACTIVATOR FROM PERFUSED RAT BLOOD VESSEL WALLS

1987 ◽  
Author(s):  
N Tranquille ◽  
J J Emeis
Keyword(s):  
Blood Vessel ◽  
Plasminogen Activator ◽  
Prostaglandin E1 ◽  
Tissue Type ◽  
Tissue Type Plasminogen Activator ◽  
Type Plasminogen Activator ◽  
Acute Increase ◽  
Vessel Walls ◽  
Isolated Rat

In a previous publication (Blood 66, 86, 1985) we suggested, on the basis of inhibitor experiments, that lipoxygenase metabolites might be involved in the release of tissue-type plasminogen activator (t-PA) from vessel walls. To test this suggestion, isolated rat hindlegs were freed of blood with Tyrode-BSA solution, and subsequently perfused with Tyrode-BSA containing various lipoxygenase metabolites. The perfusate was collected at timed intervals and assayed for t-PA activity by a spectrophoto-metric procedure. Of the compounds tested (see Table) 5-HETE did not induce PA release. However, leukotriene (LT) C4 and LTD4 dose-dependently (10-200 nM) induced the release of t-PA, which plateaued at 160 and 200 nM, respectively. Peak levels of t-PA activity were found at one minute, although the amount of t-PA released was less than that induced by PAF-acether. The PA activity released proved to be t-PA by functional and immunological criteria. Release of t-PA induced by LTC4 and LTD 4 was inhibited by the LT receptor antagonist FPL-55712 (10 μM).Prostaglandin E1 and E2, prostacyclin and ZK 36374 did not induce acute t-PA release at 0.1-2.8 μM concentrations in our model. LTC4 and LTD4 also induced an acute increase of t-PA activity in vivo in rats at a dosage of 2 μg/kg i.v.The data show that LTC4 and LTD4 can directly induce the acute release of t-PA, possibly by interacting with an endothelial LT receptor.

scholarly journals Prolyl 4‐hydroxylase subunit alpha 1 (P4HA1) is a biomarker of poor prognosis in primary melanomas, and its depletion inhibits melanoma cell invasion and disrupts tumor blood vessel walls

2020 ◽  
Vol 14 (4) ◽  
pp. 742-762 ◽  
Author(s):  
Johanna Eriksson ◽  
Vadim Le Joncour ◽  
Tiina Jahkola ◽  
Susanna Juteau ◽  
Pirjo Laakkonen ◽  
...  
Keyword(s):  
Blood Vessel ◽  
Melanoma Cell ◽  
Cell Invasion ◽  
Poor Prognosis ◽  
Tumor Blood Vessel ◽  
Vessel Walls

Presence of Afferent Nerve Fibers in Meningeal Blood Vessel Walls.

1929 ◽  
Vol 26 (4) ◽  
pp. 288-289
Author(s):  
C. D. Leake ◽  
A. G. Kammer ◽  
J. B. Hitz
Keyword(s):  
Blood Vessel ◽  
Nerve Fibers ◽  
Afferent Nerve ◽  
Afferent Nerve Fibers ◽  
Vessel Walls

Determination of a Pressure Drop in the Arteriovenous Fistula With Fluid Structure Interaction Simulations and In Vitro Methods

2017 ◽  
Author(s):  
Daniel Jodko ◽  
Tomasz Palczynski ◽  
Piotr Reorowicz ◽  
Kacper Miazga ◽  
Damian Obidowski ◽  
...  
Keyword(s):  
Pressure Drop ◽  
Blood Vessel ◽  
Arteriovenous Fistula ◽  
In Vitro Model ◽  
Experimental Methods ◽  
Measurement Methods ◽  
Patient Specific ◽  
Vessel Walls ◽  
Vitro Model

A pressure drop and its oscillations occurring in the arteriovenous fistula due to sudden changes in the velocity vector direction or the transitional or turbulent flow, related to its complicated geometry, can exert a significant impact on the blood vessel wall behaviour. On the other hand, the pressure drop cannot be precisely measured in vivo with non-invasive measurement methods. The aim of this study is to assess the pressure drop with numerical and experimental methods in the patient-specific fistula model taking into account a pulsating nature of the flow and the elasticity of blood vessel walls. An additional target is to find a correlation between these two methods. FSI and in vitro simulations of the blood flow were performed for a patient-specific model of the fistula. Basic geometrical data of the correctly functioning mature fistula were obtained with angio-computed tomography. Those data were applied to develop a spatial CAD model of the fistula, which allowed for creating a virtual model for computer simulations and an analogous in vitro model made with rapid prototyping techniques. The material used to build the in vitro model is characterised by mechanical properties similar to the arterial tissue. A non-stationary computer simulation was carried out with an ANSYS software package, keeping as many flow similarities to the experiments carried out on the test stand as possible, and where the blood mimicking fluid was a water solution of glycerine. During the experiments, the static pressure was measured downstream and upstream of the anastomosis with precise pressure transducers. The pressure drop was determined with the numerical and experimental methods, which take into account the elasticity of blood vessels. This is a novel approach, since most of similar studies were conducted on the assumption of rigid blood vessel walls. The obtained results show that the pressure drop within the fistula is not so high as reported in the literature, which is correlated with the precision of measurement methods and the fact that a large portion of the fluid energy is accumulated by the elastic walls.

Targeting novel microtentacles to reduce the adhesion of circulating tumor cells to blood vessel walls.

2009 ◽  
Author(s):  
RA Whipple-Bettes ◽  
EM Balzer ◽  
JR Yoon ◽  
EH Cho ◽  
MA Matrone ◽  
...  
Keyword(s):  
Blood Vessel ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Vessel Walls
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