Post-transient shifts in auditory lateralization: Effects of target level

2010 ◽  
Vol 127 (1) ◽  
pp. 1-4
Author(s):  
Yoav Arieh ◽  
Lawrence E. Marks
Keyword(s):  
Target Level ◽  
Auditory Lateralization

Zinc application enhances grain zinc density in genetically-zinc-biofortified wheat grown on a low-zinc calcareous soil

2018 ◽  
pp. 107-110 ◽  
Keyword(s):  
Developing Countries ◽  
Grain Yield ◽  
Calcareous Soil ◽  
Zn Deficiency ◽  
Target Level ◽  
Zn Concentration ◽  
Grain Zinc ◽  
Zn Availability ◽  
Zinc Application ◽  
Grain Zn Concentration

Human zinc (Zn) deficiency is a worldwide problem, especially in developing countries due to the prevalence of cereals in the diet. Among different alleviation strategies, genetic Zn biofortification is considered a sustainable approach. However, it may depend on Zn availability from soils. We grew Zincol-16 (genetically-Zn-biofortified wheat) and Faisalabad-08 (widely grown standard wheat) in pots with (8 mg kg−1) or without Zn application. The cultivars were grown in a low-Zn calcareous soil. The grain yield of both cultivars was significantly (P≤0.05) increased with that without Zn application. As compared to Faisalabad-08, Zincol-16 had 23 and 41% more grain Zn concentration respectively at control and applied rate of Zn. Faisalabad-08 accumulated about 18% more grain Zn concentration with Zn than Zincol-16 without Zn application. A near target level of grain Zn concentration (36 mg kg−1) was achieved in Zincol-16 only with Zn fertilisation. Over all, the findings clearly signify the importance of agronomic Zn biofortification of genetically Zn-biofortified wheat grown on a low-Zn calcareous soil.

scholarly journals Target Detection Network for SAR Images Based on Semi-Supervised Learning and Attention Mechanism

2021 ◽  
Vol 13 (14) ◽  
pp. 2686
Author(s):  
Di Wei ◽  
Yuang Du ◽  
Lan Du ◽  
Lu Li
Keyword(s):  
Feature Extraction ◽  
Supervised Learning ◽  
Target Detection ◽  
Scene Recognition ◽  
Attention Mechanism ◽  
Sar Image ◽  
Target Level ◽  
Sar Images ◽  
Training Samples ◽  
Pass Through

The existing Synthetic Aperture Radar (SAR) image target detection methods based on convolutional neural networks (CNNs) have achieved remarkable performance, but these methods require a large number of target-level labeled training samples to train the network. Moreover, some clutter is very similar to targets in SAR images with complex scenes, making the target detection task very difficult. Therefore, a SAR target detection network based on a semi-supervised learning and attention mechanism is proposed in this paper. Since the image-level label simply marks whether the image contains the target of interest or not, which is easier to be labeled than the target-level label, the proposed method uses a small number of target-level labeled training samples and a large number of image-level labeled training samples to train the network with a semi-supervised learning algorithm. The proposed network consists of a detection branch and a scene recognition branch with a feature extraction module and an attention module shared between these two branches. The feature extraction module can extract the deep features of the input SAR images, and the attention module can guide the network to focus on the target of interest while suppressing the clutter. During the semi-supervised learning process, the target-level labeled training samples will pass through the detection branch, while the image-level labeled training samples will pass through the scene recognition branch. During the test process, considering the help of global scene information in SAR images for detection, a novel coarse-to-fine detection procedure is proposed. After the coarse scene recognition determining whether the input SAR image contains the target of interest or not, the fine target detection is performed on the image that may contain the target. The experimental results based on the measured SAR dataset demonstrate that the proposed method can achieve better performance than the existing methods.

Ten hours of simulator training in arthroscopy are insufficient to reach the target level based on the Diagnostic Arthroscopic Skill Score

2021 ◽  
Author(s):  
Hermann Anetzberger ◽  
Stephan Reppenhagen ◽  
Hansjörg Eickhoff ◽  
Franz Josef Seibert ◽  
Bernd Döring ◽  
...  
Keyword(s):  
Skill Score ◽  
Simulator Training ◽  
Target Level

scholarly journals Seasonality of Hypoplastic Left Heart Syndrome and Single Ventricle Heart in Poland in the Context of Air Pollution

2021 ◽  
Vol 10 (15) ◽  
pp. 3207
Author(s):  
Iwona Strzelecka ◽  
Małgorzata Biedrzycka ◽  
Filip Franciszek Karuga ◽  
Bartosz Szmyd ◽  
Katarzyna Batarowicz ◽  
...  
Keyword(s):  
Hypoplastic Left Heart Syndrome ◽  
Single Ventricle ◽  
Single Case ◽  
Winter Season ◽  
Left Heart ◽  
Target Level ◽  
Hypoplastic Left Heart ◽  
Factors Affecting ◽  
Left Heart Syndrome ◽  
Significant Factors

Hypoplastic left heart syndrome (HLHS) and single ventricle (SV) remain a significant cause of cardiac deaths occurring in the first week of life. Their pathogenesis and seasonal frequency are still unknown. Therefore, we attempt to look at the genesis of the HLHS and SV in the context of territorial distribution as well as seasonality. A total of 193 fetuses diagnosed with HLHS and 92 with SV were selected. The frequency was analyzed depending on the year, calendar month, quarter and season (fall-winter vs. spring-summer). The spatial distribution of HLHS and SV in Poland was analyzed. We observed a statistically significant overrepresentation of HLHS formation frequency in March: 27 (14.00%) in comparison to a monthly median of 15 (IQR: 13.75–16.25; p = 0.039), as well as a significantly higher frequency of HLHS in 2007−2009: 65 cases (33.68%) in comparison to the annual mean of 13.79 ± 6.36 (p < 0.001). We noted a higher frequency of SV among parous with the last menstrual period reported in the fall/winter season of 58 vs. 34 in the spring/summer season (p = 0.014). The performed analysis also revealed significant SV overrepresentation in 2008: 11 cases (12.00%) in comparison to the annual mean of 6.57 ± 2.71 (p = 0.016). Every single case of HLHS was observed when the concentration of benzo(a)pyrene and/or PM10 exceeded the acceptable/target level. Our research indicates that both the season and the level of pollution are significant factors affecting the health of parous women and their offspring. The reason why HLHS and SV develop more frequently at certain times of the year remains unclear, therefore research on this topic should be continued, as well as on the effects of PM10 and benzo(a)pyrene exposure.

MO1027EFFICACY OF CALCINEURIN INHIBITORS IN CHILDREN WITH MONOGENIC STEROID-RESISTANT NEPHROTIC SYNDROME

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Larisa Prikhodina ◽  
Svetlana Papizh ◽  
Inna Povolotskaya
Keyword(s):  
Nephrotic Syndrome ◽  
Calcineurin Inhibitors ◽  
Compound Heterozygous ◽  
Target Level ◽  
Steroid Resistant ◽  
Steroid Resistant Nephrotic Syndrome ◽  
Pathogenic Variants ◽  
Nail Patella Syndrome

Abstract Background and Aims Monogenic causes of steroid-resistant nephrotic syndrome (SRNS) have been reported for up to one-third of children depending on age of the disease onset. Immunosuppressive treatment of genetic SRNS with calcineurin inhibitors (CNIs) is still controversial. The aim of the study was to investigate the efficacy of CNIs with focus on inducing remission and long-term kidney function in children with monogenic SRNS. Method Retrospective analysis of efficacy CNIs in five children (2M/3F) with monogenic SRNS was performed. Kidney biopsy prior CNIs revealed FSGS (n=4) and MCD (n=1). The initial cyclosporine (CsA) dose was 5 mg/kg/24h to keep a target level of 80-150 ng/ml and tacrolimus (TAC) - 0.1 mg/kg/24h to achieve a target level of 5-10 ng/ml. CsA took all 5 patients with subsequent switching to TAC in 2 children due to cosmetic side effects. The median follow-up period was 165.0 (IQR: 59.0; 185.5) months. Next generation sequencing (NGS) was used for identification of pathogenic variants in all patients. Results The median age at onset of monogenic SRNS was 33.0 (IQR: 16.5; 63.0) months. 2/5 (40%) patients presented with acute SRNS, 1/5 (20%) child with infantile NS, 1/5 (20%) - with isolated nephrotic range proteinuria with hypoalbuminemia and 1/5 (20%) - with NS and extrarenal features of Nail-Patella syndrome. NGS identified previously described pathogenic variants in all 5 children, including NPHS2 homozygous c.28dup (p.Glu87Ter) (n=1), NPHS2 compound heterozygous c.868G&gt;A (p.Val290Met) in combination with c.686G&gt;A (p.Arg229Gln) (n=1), LMX1B heterozygous c.788T&gt;G (p.Val263Gly) (n=1), LMX1B heterozygous c.737G&gt;A (p.Arg246Gln) (n=1), and COL4A3 heterozygous c.2962G&gt;A (p.Gly988Arg) variant (n=1). The median time from diagnosis to initiation of CNIs treatment was 72.0 (IQR: 33.0; 93.0) months. CNIs induced complete remission in 2/5 (40%) patients, presented with acute SRNS, including one girl with MCD due to NPHS2 compound heterozygous variants with mutation-dependent pathogenicity of one (p.R229Q) of them and one boy with FSGS due to COL4A3 heterozygous variant (n=1). Partial remission was induced by CNIs in 2/5 (40%) girls with FSGS due to LMX1B heterozygous variants with isolated SRNS (n=1) and Nail-Patella syndrome (n=1). The median duration of CNIs treatment to obtain complete or partial remission was 13.5 (IQR: 6.8; 15.8) months. Acute CNIs-associated nephrotoxicity had 2 patients with LMX1B variants. At the last follow up full and partial responders to CNIs treatment aged of 16.5 (IQR: 11.8; 17.5) years had CKD-1 (n=3) and CKD-2 (n=1). 1/5 (20%) boy with NPHS2-associated infantile NS was CNI resistant and developed CKD-5 at the age of 6.5 years with subsequent living related kidney transplantation. Conclusion We found that 4/5 (80%) children with monogenic SRNS demonstrated partial or full response to CNIs treatment with stable long-term kidney function. We assume that CNIs might improve podocyte function by stabilization of their cytoskeleton disrupted in patients with monogenic SRNS.

Effects of target level on release from masking by voice-gender difference and spatial separation between talkers

2021 ◽  
Vol 150 (4) ◽  
pp. A304-A304
Author(s):  
Yonghee Oh ◽  
Hannah Schoenfeld ◽  
Allison O. Layne ◽  
Sarah E. Bridges
Keyword(s):  
Gender Difference ◽  
Spatial Separation ◽  
Target Level ◽  
Release From Masking

scholarly journals THE EFFECTIVENESS OF COMBINATED ANTIHYPERTENSIVE TREATMENT IN PATIENTS WITH ESSENTIAL HYPERTENSION OF THE II-ND STAGE DEPENDING ON THE TYPE OF DAILY BLOOD PRESSURE PROFILE AND THE TYPE OF REMODELLING OF THE LEFT VENTRICLE

2020 ◽  
Vol 73 (1) ◽  
pp. 46-51
Author(s):  
Tetiana Y. Niushko ◽  
Olena K. Tarasiuk ◽  
Yulia K. Sikalo
Keyword(s):  
Blood Pressure ◽  
Left Ventricle ◽  
Antihypertensive Treatment ◽  
Blood Pressure Monitoring ◽  
Combined Therapy ◽  
Pressure Profile ◽  
Target Level ◽  
Pressure Monitoring ◽  
Blood Pressure Profile ◽  
Left Ventricle Remodelling

The aim: To evaluate the dynamics of structural and functional parameters of the heart, vessels in patients with hypertension of the II-nd stage under the influence of combined antihypertensive treatment depending on the type of the left ventricle remodelling and the profile of blood pressure (BP). Materials and methods: The study involved 110 patients with hypertension of the II-nd stage. The ambulatory blood pressure monitoring, echocardiography and Doppler examination of the shoulder arteries were performed. Initial treatment included bisoprolol, lisinopril, hydrochlorothiazide. With impossibility of BP lowering to the target level, amlodipine has been added. Results: higher levels of BP in the “non-dipper” patients have led to the development of more pronounced changes in the heart and vessels compared with “dipper” patients. Three-component therapy was effective in patients with lower BP. The prescription of amlodipine has been found to be necessary for the majority of “non-dipper” patients and for the minority of “dipper”. Combined therapy effectively controlled the BP at the level of the target and contributed to a decrease in the displays of remodelling of the heart and blood vessels. Conclusions: combined therapy used for 6 months reduces displays of disadaptive heart and vascular remodelling, diastolic, endothelial dysfunction. With the lack of efficacy of the therapy, which includes bisoprolol, lisinopril, hydrochlorothiazide, the adding of amlodipine to it can reach the target level of BP

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