Quantitative evaluation of fracture healing process of long bones using guided ultrasound waves: A computational feasibility study

2009 ◽  
Vol 125 (5) ◽  
pp. 2834 ◽  
Author(s):  
Xiasheng Guo ◽  
Di Yang ◽  
Dong Zhang ◽  
Weiguo Li ◽  
Yong Qiu ◽  
...  
Keyword(s):  
Fracture Healing ◽  
Quantitative Evaluation ◽  
Feasibility Study ◽  
Healing Process ◽  
Long Bones ◽  
Ultrasound Waves

scholarly journals Quantitative evaluation of fracture healing process of human bones with an impulse response method.

1998 ◽  
Vol 38 (2) ◽  
pp. 62-67
Author(s):  
Akio NOMURA ◽  
Ikuo YOSHIDA ◽  
Yukio NAKATSUCHI ◽  
Akira TSUCHIKANE
Keyword(s):  
Fracture Healing ◽  
Impulse Response ◽  
Quantitative Evaluation ◽  
Healing Process ◽  
Human Bones ◽  
Response Method

scholarly journals Computational modeling of long bones during the fracture healing process

2017 ◽  
Author(s):  
Βασιλική Ποτσίκα
Keyword(s):  
Computational Modeling ◽  
Fracture Healing ◽  
Healing Process ◽  
Long Bones

Η παρούσα διδακτορική διατριβή ασχολείται με την αριθμητική μοντελοποίηση των κατεαγότων καιοστεοπορωτικών μακρών οστών με βάση εικόνες ακουστικής μικροσκοπίας σάρωσης και τηδυνατότητα του υπερήχου να χρησιμοποιηθεί για τη διάγνωση και την παρακολούθηση τωνπαθολογιών των οστών. Ο βασικός στόχος είναι η διερεύνηση των πολύπλοκων φαινομένωνκυματικής σκέδασης που προκαλούνται από τη σύνθετη φύση του οστικού ιστού και του πώρου. Σεαυτή την κατεύθυνση, εφαρμόζονται θεωρητικές και αριθμητικές μεθοδολογίες για τον εντοπισμόμεταβολών στο πλάτος σκέδασης, την διάδοση των κυματοδηγούμενων ρυθμών και την ταχύτητα τουπρώτου αφιχθέντος σήματος σε διαδοχικά στάδια επούλωσης, καθώς και σε αριθμητικά μοντέλα τουφλοιώδους οστού με διαφορετικά ποσοστά πορώδους. Η αριθμητική προσομοίωση της διάδοσηςυπερήχου σε υγιή, κατεαγότα και οστεοπορωτικά οστά πραγματοποιήθηκε αρχικά με την ευρέωςχρησιμοποιούμενη τεχνική αξονικής μετάδοσης, ενώ η μέθοδος οπισθοσκέδασης αξιολογήθηκε επίσηςως σχετικά νέα μέθοδος. Έμφαση δίνεται στη διερεύνηση της πορώδους φύσης του πώρου και τουφλοιώδους οστού, η οποία ενσωματώθηκε στα αριθμητικά μοντέλα με τη χρήση των δεδομένωνακουστικής μικροσκοπίας σάρωσης, και σε μεταβολές που συμβαίνουν λόγω των παθολογιών τωνοστών.

ULTRASONOGRAPHIC EVALUATION OF UNION IN LONG BONES FRACTURES

2009 ◽  
Vol 12 (02) ◽  
pp. 105-112 ◽  
Author(s):  
Israel Dudkiewicz ◽  
Michael Heim ◽  
Moshe Salai ◽  
Alexander Blankstein
Keyword(s):  
Fracture Healing ◽  
Callus Formation ◽  
Healing Process ◽  
Normal Function ◽  
Long Bones ◽  
Proximal Fibula ◽  
Metatarsal Fractures ◽  
Fracture Diagnosis ◽  
One Year

Introduction: To follow fracture healing, radiography is commonly used, but it is not sensitive to the early stages of this healing process when nonossified callus is formed. Hence, radiography can lag behind the physiological events of bone healing by some weeks. Although the use of ultrasound for fracture diagnosis has been reported previously, mainly in children, the clinical use of ultrasound to follow fracture healing has rarely been commented on. The goal of the current study was to test the efficiency and efficacy of ultrasound as an alternative method for follow-up of fracture healing. Material and Methods: During a one-year period, 12 patients—six with proximal fibula fracture and six with proximal metatarsal fractures—were followed by ultrasonographic examination in parallel with the routine radiographs. Results: The ultrasound examinations revealed callus formation after one month, with the early signs of healing after ten days. Early callus was first seen on radiographs after a month. Conclusion: Ultrasound was found to be a good modality to follow up fracture healing in long bones. This modality can reduce the amount of radiation received by the patients in the follow-up of fractures, and may shorten the immobility period and hence the recovery time of returning to normal function.

Ultrasonic Diagnosis for Bone Fracture Healing Process

2020 ◽  
Author(s):  
Satoshi Kimura ◽  
Keisuke Oe ◽  
Yohei Kumabe ◽  
Tomoaki Fukui ◽  
Takahiro Niikura ◽  
...  
Keyword(s):  
Fracture Healing ◽  
Bone Fracture ◽  
Healing Process ◽  
Ultrasonic Diagnosis ◽  
Bone Fracture Healing

scholarly journals Can Optimizing the Mechanical Environment Deliver a Clinically Significant Reduction in Fracture Healing Time?

Biomedicines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 691
Author(s):  
Jan Barcik ◽  
Devakara R. Epari
Keyword(s):  
Fracture Healing ◽  
Bone Healing ◽  
Mechanical Stimulation ◽  
Callus Formation ◽  
Weight Bearing ◽  
Healing Process ◽  
Healing Time ◽  
Mechanical Environment ◽  
Clinically Significant ◽  
The Impact

The impact of the local mechanical environment in the fracture gap on the bone healing process has been extensively investigated. Whilst it is widely accepted that mechanical stimulation is integral to callus formation and secondary bone healing, treatment strategies that aim to harness that potential are rare. In fact, the current clinical practice with an initially partial or non-weight-bearing approach appears to contradict the findings from animal experiments that early mechanical stimulation is critical. Therefore, we posed the question as to whether optimizing the mechanical environment over the course of healing can deliver a clinically significant reduction in fracture healing time. In reviewing the evidence from pre-clinical studies that investigate the influence of mechanics on bone healing, we formulate a hypothesis for the stimulation protocol which has the potential to shorten healing time. The protocol involves confining stimulation predominantly to the proliferative phase of healing and including adequate rest periods between applications of stimulation.

A new approach for initial callus growth during fracture healing in long bones

2021 ◽  
pp. 106262
Author(s):  
J.M. Naveiro ◽  
S. Puértolas ◽  
J. Rosell ◽  
A. Hidalgo ◽  
E. Ibarz ◽  
...  
Keyword(s):  
Fracture Healing ◽  
Callus Growth ◽  
Long Bones ◽  
New Approach

Ultrasonographic and Radiographic Assessment of Uncomplicated Secondary Fracture Healing of Long Bones in Dogs and Cats

2005 ◽  
Vol 34 (2) ◽  
pp. 99-107 ◽  
Author(s):  
Marije Risselada ◽  
Martin Kramer ◽  
Hilde de Rooster ◽  
Olivier Taeymans ◽  
Piet Verleyen ◽  
...  
Keyword(s):  
Fracture Healing ◽  
Long Bones ◽  
Radiographic Assessment ◽  
Secondary Fracture

scholarly journals A finite element inverse analysis to assess functional improvement during the fracture healing process

2010 ◽  
Vol 43 (3) ◽  
pp. 557-562 ◽  
Author(s):  
Jared A. Weis ◽  
Michael I. Miga ◽  
Froilán Granero-Moltó ◽  
Anna Spagnoli
Keyword(s):  
Finite Element ◽  
Fracture Healing ◽  
Inverse Analysis ◽  
Healing Process ◽  
Functional Improvement

scholarly journals Insights into the Cellular and Molecular Mechanisms That Govern the Fracture-Healing Process: A Narrative Review

2021 ◽  
Vol 10 (16) ◽  
pp. 3554
Author(s):  
Dionysios J. Papachristou ◽  
Stavros Georgopoulos ◽  
Peter V. Giannoudis ◽  
Elias Panagiotopoulos
Keyword(s):  
Fracture Healing ◽  
Bone Repair ◽  
Molecular Mechanisms ◽  
Current Knowledge ◽  
Healing Process ◽  
Bone Architecture ◽  
Multi Stage ◽  
Stage Process ◽  
And Function ◽  
The Impact

Fracture-healing is a complex multi-stage process that usually progresses flawlessly, resulting in restoration of bone architecture and function. Regrettably, however, a considerable number of fractures fail to heal, resulting in delayed unions or non-unions. This may significantly impact several aspects of a patient’s life. Not surprisingly, in the past few years, a substantial amount of research and number of clinical studies have been designed, aiming at shedding light into the cellular and molecular mechanisms that regulate fracture-healing. Herein, we present the current knowledge on the pathobiology of the fracture-healing process. In addition, the role of skeletal cells and the impact of marrow adipose tissue on bone repair is discussed. Unveiling the pathogenetic mechanisms that govern the fracture-healing process may lead to the development of novel, smarter, and more effective therapeutic strategies for the treatment of fractures, especially of those with large bone defects.

FRACTURE HEALING SIMULATION REGULATED BY FORCE AND OXYGEN

2019 ◽  
Vol 19 (07) ◽  
pp. 1940029
Author(s):  
MONAN WANG ◽  
XINYU WANG ◽  
QIYOU YANG
Keyword(s):  
Simulation Model ◽  
Fracture Healing ◽  
Control Method ◽  
Mechanical Stability ◽  
Healing Process ◽  
Tissue Differentiation ◽  
Simulation Program ◽  
Spatial And Temporal Variation ◽  
Oxygen Levels ◽  
Axial Stability

According to the mechanical conditions of fracture fixation and the oxygen levels in the tissues, a simulation model of fracture healing process was built to describe the relationship among mechanical stability, oxygen levels in tissues and tissue differentiation during the second fracture healing. Different from the previous simulation model, in this paper, we took the three-dimensional model as the research object, solved the mechanical stimulation by finite element method, established the partial differential equation to solve the spatial and temporal variation of the oxygen in tissues. The process of tissue differentiation was described by fuzzy control method. The initial stage of fracture healing, intramembranous ossification, chondrogenesis, cartilage calcification and endochondral ossification during the fracture healing process were simulated, and the properties of tissue materials were continuously updated to complete the iterative process. The simulation program of fracture healing process was independently developed in Eclipse environment, and the simulation results were compared with experimental data and those of other fracture healing simulation models to verify the simulation program in this paper. Finally, the processes of transverse fracture healing in rats with different axial stability under normoxic, hypoxic and hyperoxic conditions was simulated, and the effects of different tissue oxygen levels and interosseous stabilities on fracture healing were analyzed. It is concluded by simulation that the delayed healing or non-union of bone will occur when in state of tissue hypoxia or interosseous instability, normal healing will occur when in state of tissue normoxia, and the healing will be accelerated when in state of tissue hyperoxia.

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