Bernoulli coding on the auditory nerve and its implications for central auditory processing

2008 ◽  
Vol 123 (5) ◽  
pp. 3715-3715
Author(s):  
Robert A. Houde ◽  
James M. Hillenbrand
Keyword(s):  
Auditory Processing ◽  
Auditory Nerve ◽  
Central Auditory Processing

scholarly journals Biased Auditory Nerve Central Synaptopathy Exacerbates Age-related Hearing Loss

2020 ◽  
Author(s):  
Meijian Wang ◽  
Chuangeng Zhang ◽  
Shengyin Lin ◽  
Yong Wang ◽  
Benjamin J. Seicol ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Auditory Processing ◽  
Auditory Nerve ◽  
Spiral Ganglion ◽  
Central Auditory Processing ◽  
Endbulb Of Held ◽  
Age Related ◽  
Central Synapses ◽  
Ganglion Neurons ◽  
Age Related Hearing Loss

SUMMARYSound information is transmitted from the cochlea to the brain by different subtypes of spiral ganglion neurons (SGN), which show varying degrees of vulnerbility under pathological conditions. It remains unclear how information from these SGNs reassemble among target neurons in the cochlear nucleus (CN) at the auditory nerve (AN) central synapses, and how different synapses change during hearing loss. Combining immunohistochemistry with electrophysiology, we investigated the giant endbulb of Held synapses and their postsynaptic bushy neurons in mice under normal hearing and age-related hearing loss (ARHL). We found that calretinin-expressing and non-calretinin-expressing endbulbs converge at continuously different ratios onto bushy neurons with varying physiological properties. Endbulbs degenerate during ARHL, and the degeneration is more severe in non-calretinin-expressing synapses, which correlates with a gradual decrease in neuronal subpopulation predominantly innervated by these inputs. Our findings suggest that biased AN central synaptopathy and shifted CN neuronal composition underlie reduced auditory input and altered central auditory processing during ARHL.

Temporal and Frequency Characteristics of Cartwheel Cells in the Dorsal Cochlear Nucleus of the Awake Mouse

2007 ◽  
Vol 98 (2) ◽  
pp. 744-756 ◽  
Author(s):  
Christine V. Portfors ◽  
Patrick D. Roberts
Keyword(s):  
Auditory Processing ◽  
Cochlear Nucleus ◽  
Auditory Nerve ◽  
Active Role ◽  
Auditory Pathway ◽  
Dorsal Cochlear Nucleus ◽  
Central Auditory Processing ◽  
Complex Frequency ◽  
Principal Cells ◽  
Cartwheel Cells

The dorsal cochlear nucleus (DCN) is an initial site of central auditory processing and also the first site of multisensory convergence in the auditory pathway. The auditory nerve imparts a tonotopic frequency organization on the responses of principal cells in the DCN. Cartwheel cells modify the responses of principal cells, but they do not receive direct auditory nerve input. This study shows that cartwheel cells respond well to tonal stimuli in the awake mouse and they have a well-defined characteristic frequency that corresponds to the tonotopic organization of the DCN. The auditory responses of cartwheel cells exhibit complex spectrotemporal responses to tones, with excitation and inhibition modulating the firing patterns in both frequency and time after onset of the stimulus. Temporal responses to best-frequency tones are highly variable between cartwheel cells, but a simple model is used to unify this variability as differences in the timing of synaptic currents. Cartwheel cell responses to two-tone stimuli show that interactions from different frequencies affect the output of cartwheel cells. The results suggest that at this primary auditory structure, processing of sound at one frequency can be modified by sounds of different frequency. These complex frequency and temporal interactions in cartwheel cells suggest that these neurons play an active role in basic sound processing.

The glucocorticoid antagonist mifepristone attenuates sound‐induced long‐term deficits in auditory nerve response and central auditory processing in female rats

2018 ◽  
Vol 32 (6) ◽  
pp. 3005-3019 ◽  
Author(s):  
Wibke Singer ◽  
Kamyar Kasini ◽  
Marie Manthey ◽  
Philipp Eckert ◽  
Philipp Armbruster ◽  
...  
Keyword(s):  
Auditory Processing ◽  
Auditory Nerve ◽  
Female Rats ◽  
Central Auditory Processing ◽  
Nerve Response

scholarly journals Speech Processing Disorder in Neural Hearing Loss

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Joseph P. Pillion
Keyword(s):  
Speech Processing ◽  
Auditory Processing ◽  
Neurological Disorders ◽  
Auditory Neuropathy ◽  
Central Auditory Processing ◽  
Temporal Lobes ◽  
Electrophysiological Tests ◽  
Bilateral Lesions ◽  
Clinical Conditions ◽  
Inferior Colliculi

Deficits in central auditory processing may occur in a variety of clinical conditions including traumatic brain injury, neurodegenerative disease, auditory neuropathy/dyssynchrony syndrome, neurological disorders associated with aging, and aphasia. Deficits in central auditory processing of a more subtle nature have also been studied extensively in neurodevelopmental disorders in children with learning disabilities, ADD, and developmental language disorders. Illustrative cases are reviewed demonstrating the use of an audiological test battery in patients with auditory neuropathy/dyssynchrony syndrome, bilateral lesions to the inferior colliculi, and bilateral lesions to the temporal lobes. Electrophysiological tests of auditory function were utilized to define the locus of dysfunction at neural levels ranging from the auditory nerve, midbrain, and cortical levels.

scholarly journals Auditory Processing Disorders in Elderly Persons vs. Linguistic and Emotional Prosody

2021 ◽  
Vol 18 (12) ◽  
pp. 6427
Author(s):  
Anna Rasmus ◽  
Aleksandra Błachnio
Keyword(s):  
Interpersonal Relationships ◽  
Auditory Processing ◽  
Temporal Pattern ◽  
Right Hemisphere ◽  
Elderly Persons ◽  
Central Auditory Processing ◽  
Auditory Processing Disorders ◽  
Emotional Prosody ◽  
Frequency Pattern ◽  
Central Processing

Background: Language communication, which is one of the basic forms of building and maintaining interpersonal relationships, deteriorates in elder age. One of the probable causes is a decline in auditory functioning, including auditory central processing. The aim of the present study is to evaluate the profile of central auditory processing disorders in the elderly as well as the relationship between these disorders and the perception of emotional and linguistic prosody. Methods: The Right Hemisphere Language Battery (RHLB-PL), and the Brain-Boy Universal Professional (BUP) were used. Results: There are statistically significant relationships between emotional prosody and: spatial hearing (r(18) = 0.46, p = 0.04); the time of the reaction (r(18) = 0.49, p = 0.03); recognizing the frequency pattern (r(18) = 0.49, p = 0.03 (4); and recognizing the duration pattern (r(18) = 0.45, p = 0.05. There are statistically significant correlations between linguistic prosody and: pitch discrimination (r(18) = 0.5, p = 0.02); recognition of the frequency pattern (r(18) = 0.55, p = 0.01); recognition of the temporal pattern; and emotional prosody (r(18) = 0.58, p = 0.01). Conclusions: The analysis of the disturbed components of auditory central processing among the tested samples showed a reduction in the functions related to frequency differentiation, the recognition of the temporal pattern, the process of discriminating between important sounds, and the speed of reaction. De-automation of the basic functions of auditory central processing, which we observe in older age, lowers the perception of both emotional and linguistic prosody, thus reducing the quality of communication in older people.

scholarly journals Central Auditory Processing and Cognitive Functions in Children

2021 ◽  
Author(s):  
Nadja Cristina Furtado Back ◽  
Ana Chrystina de Souza Crippa ◽  
Tatiana Izabelle Jaworski de Sá Riechi ◽  
Liliane Desgualdo Pereira
Keyword(s):  
Executive Function ◽  
Cognitive Deficits ◽  
Cognitive Functions ◽  
Auditory Processing ◽  
Auditory Attention ◽  
Auditory Processing Disorder ◽  
Behavior Rating ◽  
Central Auditory Processing ◽  
Behavior Rating Inventory ◽  
And Behavior

Abstract Introduction Nowadays, there is no consensus on whether central auditory processing disorder is a primary or a secondary deficit to other cognitive deficits. A better understanding of the association between cognitive functions and central auditory skills may help elucidate this dilemma. Objective To investigate possible associations between auditory abilities and cognitive functions in schoolchildren. Methods Fifty-eight schoolchildren, aged between 8 years and 0 months old and 11 years and 11 months old, who underwent the following tests: masking level difference, gaps in noise, pitch pattern sequence test, dichotic digits test, sustained auditory attention ability test, Wechsler intelligence scale for children – IV, junior Hayling test, five digits test, and behavior rating inventory of executive function. Results Significant correlations were found between the hearing ability of temporal resolution and executive functions, temporal ordering/sequencing, binaural integration and separation, and sustained auditory attention, operational memory, inhibitory control, and cognitive flexibility; binaural integration was also associated with intelligence. The statistically significant positive correlation found between the ability of binaural interaction and the components of emotional control and behavior regulation of the behavior rating inventory of executive function was unexpected. Conclusion The associations identified reinforce the complexity of the tasks involved in the evaluation of central auditory processing and the need for multidisciplinary evaluation for the differential diagnosis of auditory processing disorder. Confirmation of the presence or absence of comorbidities between different disorders allows directing the therapeutic behaviors and reducing the impact of possible auditory and/or cognitive deficits in the different daily life situations of children.

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