scholarly journals Differences in auditory nerve fiber responses in regard to inner and outer hair cells

1978 ◽  
Vol 64 (S1) ◽  
pp. S135-S135
Author(s):  
M. Nomoto ◽  
M. Maekawa
Keyword(s):  
Nerve Fiber ◽  
Hair Cells ◽  
Auditory Nerve ◽  
Outer Hair Cells ◽  
Auditory Nerve Fiber

scholarly journals Resolution of subcomponents of synaptic release from post-synaptic currents in rat hair-cell/auditory-nerve fiber synapses

2020 ◽  
Author(s):  
Eric D. Young ◽  
Jingjing Sherry Wu ◽  
Mamiko Niwa ◽  
Elisabeth Glowatzki
Keyword(s):  
Hair Cell ◽  
Nerve Fiber ◽  
Hair Cells ◽  
Auditory Nerve ◽  
Neurotransmitter Release ◽  
Auditory Nerve Fiber ◽  
Vesicle Release ◽  
Synaptic Currents ◽  
Synaptic Release

AbstractThe synapse between inner hair cells and auditory nerve fiber dendrites shows large EPSCs, which are either monophasic or multiphasic. Multiquantal or uniquantal flickering release have been proposed to underlie the unusual multiphasic waveforms. Here the nature of multiphasic waveforms is analyzed using EPSCs recorded in vitro in rat afferent dendrites. Spontaneous EPSCs were deconvolved into a sum of presumed release events with monophasic EPSC waveforms. Results include: first, the charge of EPSCs is about the same for multiphasic versus monophasic EPSCs. Second, EPSC amplitudes decline with the number of release events per EPSC. Third, there is no evidence of a mini-EPSC. Most results can be accounted for by versions of either uniquantal or multiquantal release. However, serial neurotransmitter release in multiphasic EPSCs shows properties that are not fully explained by either model, especially that the amplitudes of individual release events is established at the beginning of a multiphasic EPSC, constraining possible models of vesicle release.

scholarly journals Electrical tuning and transduction in short hair cells of the chicken auditory papilla

2013 ◽  
Vol 109 (8) ◽  
pp. 2007-2020 ◽  
Author(s):  
Xiaodong Tan ◽  
Maryline Beurg ◽  
Carole Hackney ◽  
Shanthini Mahendrasingam ◽  
Robert Fettiplace
Keyword(s):  
Hair Cells ◽  
Calcium Binding ◽  
Outer Hair Cells ◽  
Basilar Papilla ◽  
Resting Potential ◽  
Auditory Nerve Fiber ◽  
Buffer Concentration ◽  
Short Hair ◽  
Open Probability ◽  
Calbindin D

The avian auditory papilla contains two classes of sensory receptor, tall hair cells (THCs) and short hair cells (SHCs), the latter analogous to mammalian outer hair cells with large efferent but sparse afferent innervation. Little is known about the tuning, transduction, or electrical properties of SHCs. To address this problem, we made patch-clamp recordings from hair cells in an isolated chicken basilar papilla preparation at 33°C. We found that SHCs are electrically tuned by a Ca2+-activated K+ current, their resonant frequency varying along the papilla in tandem with that of the THCs, which also exhibit electrical tuning. The tonotopic map for THCs was similar to maps previously described from auditory nerve fiber measurements. SHCs also possess an A-type K+ current, but electrical tuning was observed only at resting potentials positive to −45 mV, where the A current is inactivated. We predict that the resting potential in vivo is approximately −40 mV, depolarized by a standing inward current through mechanotransducer (MT) channels having a resting open probability of ∼0.26. The resting open probability stems from a low endolymphatic Ca2+ concentration (0.24 mM) and a high intracellular mobile Ca2+ buffer concentration, estimated from perforated-patch recordings as equivalent to 0.5 mM BAPTA. The high buffer concentration was confirmed by quantifying parvalbumin-3 and calbindin D-28K with calibrated postembedding immunogold labeling, demonstrating >1 mM calcium-binding sites. Both proteins displayed an apex-to-base gradient matching that in the MT current amplitude, which increased exponentially along the papilla. Stereociliary bundles also labeled heavily with antibodies against the Ca2+ pump isoform PMCA2a.

Auditory nerve fiber responses following chronic cochlear de-efferentation

1999 ◽  
Vol 406 (1) ◽  
pp. 72-86 ◽  
Author(s):  
Xiang Yang Zheng ◽  
Donald Henderson ◽  
Sandra L. McFadden ◽  
Da Lian Ding ◽  
Richard J. Salvi
Keyword(s):  
Nerve Fiber ◽  
Auditory Nerve ◽  
Auditory Nerve Fiber

Suppression of Auditory-Nerve-Fiber Responses to Off-CF Tones

2011 ◽  
Author(s):  
Maria A. Berezina ◽  
John J. Guinan ◽  
Christopher A. Shera ◽  
Elizabeth S. Olson
Keyword(s):  
Nerve Fiber ◽  
Auditory Nerve ◽  
Auditory Nerve Fiber
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