Integration of outer hair cell activity in a one-dimensional cochlear model

2004 ◽  
Vol 115 (5) ◽  
pp. 2185-2192 ◽  
Author(s):  
Azaria Cohen ◽  
Miriam Furst
Keyword(s):  
Hair Cell ◽  
Outer Hair Cell ◽  
Cell Activity ◽  
One Dimensional ◽  
Cochlear Model

Outer hair cell activity of the cochlea in patients with iron deficiency anemia

2004 ◽  
Vol 31 (4) ◽  
pp. 389-394 ◽  
Author(s):  
Turker Cetin ◽  
Sertac Yetiser ◽  
Engin Cekin ◽  
Coskun Durmus ◽  
Oral Nevruz ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Hair Cell ◽  
Iron Deficiency Anemia ◽  
Outer Hair Cell ◽  
Cell Activity ◽  
Deficiency Anemia

Including Physiologically Based Nonlinearity in a Cochlear Model

2010 ◽  
Vol 132 (2) ◽  
Author(s):  
Xiaoai Jiang ◽  
Karl Grosh
Keyword(s):  
Outer Hair Cell ◽  
Basilar Membrane ◽  
Fluid Model ◽  
Response Characteristic ◽  
Nonlinear Circuit ◽  
One Dimensional ◽  
Cochlear Model ◽  
Distortion Products ◽  
Voltage Dependent ◽  
Filtering Function

The outer hair cell (OHC) is known to be the main source of nonlinear activity in the cochlea. In this work, we used a one-dimensional fluid model of the cochlea coupled to a nonlinear model of the mechanical to electric coupling of the OHC and the basilar membrane (BM). The nonlinearity arises from the electromotility and the voltage-dependent stiffness of the OHC, and from the displacement dependence of the conductance of the stereocilia. We used a reciprocal nonlinear piezoelectric model of the OHC in combination with a model of stereocilia conductance depending on BM displacement (which resulted in a nonlinear circuit model). The mechanical properties of the various components of the model were motivated from physiological components of the cochlea. Simulations showed realistic gains in the activity, response saturation at high force level, and two-tone forcing generated distortion products while the shape of the filtering function was not as accurately replicated. We conclude that a cochlear model with a simple 1D fluid representation in combination with nonlinear OHC-stereocilia electromechanical response characteristic qualitatively predicts the compression property of the cochlea and can be used as a tool to investigate the relative importance of the various nonlinearities.

A cochlear model using feed-forward outer-hair-cell forces

1995 ◽  
Vol 86 (1-2) ◽  
pp. 132-146 ◽  
Author(s):  
C.Daniel Geisler ◽  
Chunning Sang
Keyword(s):  
Hair Cell ◽  
Outer Hair Cell ◽  
Feed Forward ◽  
Cochlear Model

scholarly journals Suppression of Otoacoustic Emission using Schroeder Harmonic Complexes as Suppressing Stimuli

2017 ◽  
Vol 16 (1) ◽  
Author(s):  
Fazlin Binti Suratman
Keyword(s):  
Hair Cell ◽  
Outer Hair Cell ◽  
Cell Activity ◽  
Otoacoustic Emission ◽  
Protective Mechanism ◽  
Distortion Product ◽  
Amplitude Difference ◽  
Active Mechanism ◽  
Contralateral Ear ◽  
Medial Olivocochlear

Introduction: Medial Olivocochlear Reflex (MOCR) causes inhibition of outer hair cell activity upon noise stimulation and acts as protective mechanism of the ear against noise. MOCR  can be recorded through the suppression of Otoacoustic Emission (OAE). The mechanism of MOCR function was still unclear and whether the function is affected by the phase of incoming noise requires further investigation. This research aimed to identify the effect of MOCR activity ; i) at different frequency; ii) when using different phases of Schroeder harmonic complexes as the suppressor noise.  Materials and method: Twenty six normal hearing subjects were recruited. The suppression was analysed by looking at amplitude difference of Distortion Product of Otoacoustic Emission (DPOAE) in the absence of noise and in the presence of noise in contralateral ear, at different tested frequencies (1, 1.5, 2, 3, 4, 6 kHz).  Results: There was significantly higher suppression amplitude for frequency 1-2 kHz compared to higher frequencies (p<0.05). Significant higher suppression was observed when negative phase of Schroeder harmonic complexes (c: -1) was used as suppressing stimuli compared to that of positive phase (c: +1) (p<0.05).  Conclusion: These findings showed that MOCR; i) is enhanced at mid-frequency region, and ii) has the ability to inhibit the outer hair cell active mechanism differently upon stimulation with different phases of noise.

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