Noninvasive determination of the arterial input function of an anticancer drug from dynamic PET scans using the population approach

1999 ◽  
Vol 26 (4) ◽  
pp. 609-615 ◽  
Author(s):  
Jutta Kissel ◽  
Rüdiger E. Port ◽  
Joachim Zaers ◽  
Matthias E. Bellemann ◽  
Ludwig G. Strauss ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
Arterial Input Function ◽  
Input Function ◽  
Dynamic Pet ◽  
Population Approach ◽  
Pet Scans

Recovery-Koeffizienten zur Quantifizierung der arteriellen Inputfunktion aus dynamischen PET-Messungen: experimentelle und theoretische Bestimmung

2002 ◽  
Vol 41 (04) ◽  
pp. 184-190 ◽  
Author(s):  
M. E. Bellemann ◽  
H. Hauser ◽  
J. Doll ◽  
G. Brix
Keyword(s):  
Blood Vessel ◽  
Concentration Ratio ◽  
Activity Concentration ◽  
Background Activity ◽  
Arterial Input Function ◽  
Input Function ◽  
Surrounding Tissue ◽  
Large Artery ◽  
Dynamic Pet ◽  
Large Arteries

Summary Aim: For kinetic modelling of dynamic PET data, the arterial input function can be determined directly from the PET scans if a large artery is visualized on the images. It was the purpose of this study to experimentally and theoretically determine recovery coefficients for cylinders as a function of the diameter and level of background activity. Methods: The measurements were performed using a phantom with seven cylinder inserts (Ø = 5-46 mm). The cylinders were filled with an aqueous 68Ga solution while the main chamber was filled with a 18F solution in order to obtain a varying concentration ratio between the cylinders and the background due to the different isotope half lives. After iterative image reconstruction, the activity concentrations were measured in the center of the cylinders and the recovery coefficients were calculated as a function of the diameter and the background activity. Based on the imaging properties of the PET system, we also developed a model for the quantitative assessment of recovery coefficients. Results: The functional dependence of the measured recovery data from the cylinder diameter and the concentration ratio is well described by our model. For dynamic PET measurements, the recovery correction must take into account the decreasing concentration ratio between the blood vessel and the surrounding tissue. Under the realized measurement and data analysis conditions, a recovery correction is required for vessels with a diameter of up to 25 mm. Conclusions: Based on the experimentally verified model, the activity concentration in large arteries can be calculated from the measured activity concentration in the blood vessel and the background activity. The presented approach offers the possibility to determine the arterial input function for pharmacokinetic PET studies non-invasively from large arteries (especially the aorta).

scholarly journals Simultaneous acquisition of dynamic PET-MRI: arterial input function using DSC-MRI and [18F]-FET

2015 ◽  
Vol 2 (S1) ◽  
Author(s):  
Liliana Caldeira ◽  
Seong Dae Yun ◽  
Nuno da Silva ◽  
Christian Filss ◽  
Juergen Scheins ◽  
...  
Keyword(s):  
Arterial Input Function ◽  
Input Function ◽  
Dynamic Pet ◽  
Simultaneous Acquisition ◽  
Dsc Mri

scholarly journals A New Approach of Weighted Integration Technique Based on Accumulated Images Using Dynamic PET and H152O

1991 ◽  
Vol 11 (3) ◽  
pp. 492-501 ◽  
Author(s):  
Takashi Yokoi ◽  
Iwao Kanno ◽  
Hidehiro Iida ◽  
Shuichi Miura ◽  
Kazuo Uemura
Keyword(s):  
Arterial Input Function ◽  
Signal To Noise Ratio ◽  
Time Integration ◽  
Statistical Error ◽  
Normal Subjects ◽  
Input Function ◽  
New Technique ◽  
Dynamic Pet ◽  
Weighting Functions ◽  
Positron Emission

We developed a new technique of weighted integration for the measurement of local cerebral blood flow (LCBF) and the blood-tissue partition coefficient ip) using dynamic positron emission tomography (PET) and H152O. The weighted integration in the new technique is carried out on the equation of the first time integration of the Kety–Schmidt differential equation. Practically, serially accumulated images with sequentially prolonged accumulation times are weighted by two arbitrary functions. The weighting functions do not have to be differentiated because of the exclusion of the differential term in the starting equation. Consequently, the method does not require data at the end of the scan. The technique was applied to H152O dynamic PET performed on four normal subjects, and was verified to provide a better signal-to-noise ratio than the previously developed integrated projection (IP) technique. Computer simulations were carried out to investigate the effects of statistical noise, tissue heterogeneity, and time delay and dispersion in arterial input function. The simulation showed that the new technique provided about a 1.4 times lower statistical error in both LCBF and p at 50 ml 100 g−1 min−1 compared to the IP technique, and it should be noted that the new technique was less sensitive to the shape of the weighting functions. The new technique provides a new strategy with respect to the statistical error for estimation of LCBF and p.

Gender dependent rate of metabolism of the opioid receptor-PET ligand [18F]fluoroethyldiprenorphine

2006 ◽  
Vol 45 (05) ◽  
pp. 197-200 ◽  
Author(s):  
M. E. Spilker ◽  
T. Sprenger ◽  
A. I. Hauser ◽  
S. Platzer ◽  
H. Boecker ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Arterial Input Function ◽  
Input Function ◽  
Plasma Metabolites ◽  
Quantitative Measurements ◽  
Dependent Rate ◽  
Positron Emission ◽  
Methodological Errors ◽  
Pet Scans ◽  
Radioactive Species

Summary:Aim: The morphinane-derivate 6-O-(2-[18F]fluoroethyl)- 6-O-desmethyldiprenorphine ([18F]FDPN) is a nonselective opioid receptor ligand currently used in positron emission tomography (PET). Correction for plasma metabolites of the arterial input function is necessary for quantitative measurements of [18F]FDPN binding. A study was undertaken to investigate if there are gender dependent differences in the rate of metabolism of [18F]FDPN. Methods: The rate of metabolism of [18F]FDPN was mathematically quantified by fitting a bi-exponential function to each individual’s dynamic metabolite data. Results: No statistically significant gender differences were found for age, weight, body mass index or dose. However, significant differences (p <0.01) in two of the four kinetic parameters describing the rate of metabolism were found between the two groups, with women metabolizing [18F]FDPN faster than men. These differences were found in the contribution of the fast and slow kinetic components of the model describing the distribution of radioactive species in plasma, indicating a higher rate of enzyme-dependent degradation of [18F]FDPN in women than in men. Conclusion: The findings reinforce the need for individualized metabolite correction during [18F]FDPN-PET scans and also indicate that in certain cases, grouping according to gender could be performed in order to minimize methodological errors of the input function prior to kinetic analyses.

scholarly journals Validation of a Less-Invasive Method for Measurement of Serotonin Synthesis Rate with α-[11C]Methyl-Tryptophan

1998 ◽  
Vol 18 (10) ◽  
pp. 1121-1129 ◽  
Author(s):  
Sadahiko Nishizawa ◽  
Marco Leyton ◽  
Hidehiko Okazawa ◽  
Chawki Benkelfat ◽  
Shadreck Mzengeza ◽  
...  
Keyword(s):  
Exposure Time ◽  
Arterial Input Function ◽  
Venous Blood ◽  
Input Function ◽  
Venous Sinus ◽  
Synthesis Rate ◽  
Dynamic Pet ◽  
Serotonin Synthesis ◽  
Less Invasive ◽  
Invasive Method

We tested in normal human subjects a less invasive method to obtain plasma input function required in the calculation of the brain serotonin synthesis rate measured with positron emission tomography (PET) and α-[11C]methyl-tryptophan (α-MTrp). The synthesis rates derived with the arterial input function were compared to those derived from venous plasma and venous sinus time-radioactivity curves obtained from dynamic PET images. Dynamic PET images were obtained for the lengths up to 90 minutes after an injection of α-MTrp (400 to 800 MBq). Input functions were generated from both artery and vein in three subjects, and from artery only in two subjects. Net unidirectional uptake constants of α-MTrp (K*; mL/g/min) were calculated in several brain regions graphically using data between 20 and 60 minutes after injection with different input functions. In the five subjects with arterial sampling, we tested two methods for correcting the input functions from the venous samples: (1) normalization to the mean exposure time at 20 minutes from arterial curve; and (2) the use of the venous sinus curve for the first 20 minutes. Venous curves coincided with the arterial ones after about 20 minutes. When the venous curves were used, there was an underestimation of the area under the curves up to 20 minutes, resulting in a 5% to 30% overestimation of K* values. Combined use of the sinus curve up to 20 minutes and venous curve from 20 to 60 minutes as an input function resulted in the K* (mL/g/min) values larger by 7.1 ± 3.8% than the K* values estimated with the arterial input function. Normalization of the venous curve to the exposure time at 20 minutes obtained from the arterial plasma curve resulted in a bias in the K* of about −0.34 ± 3.32%. The bias from the K* values was propagated to the serotonin synthesis rates. The use of a combination of the venous blood samples and venous sinus as the input function resulted in an acceptable bias in the serotonin synthesis rates from the tissue time-radioactivity curves generated by PET.

scholarly journals Development and performance test of an online blood sampling system for determination of the arterial input function in rats

2015 ◽  
Vol 2 (1) ◽  
Author(s):  
Friedrich Roehrbacher ◽  
Jens P Bankstahl ◽  
Marion Bankstahl ◽  
Thomas Wanek ◽  
Johann Stanek ◽  
...  
Keyword(s):  
Performance Test ◽  
Arterial Input Function ◽  
Input Function ◽  
Blood Sampling ◽  
Sampling System ◽  
And Performance
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