A simulation of emission and transmission noise propagation in cardiac SPECT imaging with nonuniform attenuation correction

1994 ◽  
Vol 21 (10) ◽  
pp. 1565-1576 ◽  
Author(s):  
Chi-Hua Tung ◽  
Grant T. Gullberg
Keyword(s):  
Attenuation Correction ◽  
Spect Imaging ◽  
Cardiac Spect ◽  
Noise Propagation ◽  
Nonuniform Attenuation Correction

scholarly journals The Role of CT-Based Attenuation Correction and Collimator Blurring Correction in Striatal Spect Quantification

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
J. M. Warwick ◽  
S. Rubow ◽  
M. du Toit ◽  
E. Beetge ◽  
P. Carey ◽  
...  
Keyword(s):  
Attenuation Correction ◽  
Single Photon ◽  
Photon Emission ◽  
Patient Data ◽  
Spect Imaging ◽  
Emission Computed Tomography ◽  
Phantom Data ◽  
Specific Uptake ◽  
Spect Reconstruction ◽  
Nonuniform Attenuation Correction

Purpose. Striatal single photon emission computed tomography (SPECT) imaging of the dopaminergic system is becoming increasingly used for clinical and research studies. The question about the value of nonuniform attenuation correction has become more relevant with the increasing availability of hybrid SPECT-CT scanners. In this study, the value of nonuniform attenuation correction and correction for collimator blurring were determined using both phantom data and patient data. Methods. SPECT imaging was performed using 7 anthropomorphic phantom measurements, and 14 patient studies using [I-123]-FP-CIT (DATSCAN). SPECT reconstruction was performed using uniform and nonuniform attenuation correction and collimator blurring corrections. Recovery values (phantom data) or average-specific uptake ratios (patient data) for the different reconstructions were compared at similar noise levels. Results. For the phantom data, improved recovery was found with nonuniform attenuation correction and collimator blurring corrections, with further improvement when performed together. However, for patient data the highest average specific uptake ratio was obtained using collimator blurring correction without nonuniform attenuation correction, probably due to subtle SPECT-CT misregistration. Conclusions. This study suggests that an optimal brain SPECT reconstruction (in terms of the lowest bias) in patients would include a correction for collimator blurring and uniform attenuation correction.

scholarly journals Quality and utility of [123I]I-metaiodobenzylguanidine cardiac SPECT imaging in nondiabetic postinfarction heart failure patients qualified for implantable cardioverter defibrillator

2021 ◽  
Author(s):  
Anna Teresińska ◽  
Olgierd Woźniak ◽  
Aleksander Maciąg ◽  
Jacek Wnuk ◽  
Jarosław Jezierski ◽  
...  
Keyword(s):  
Heart Failure ◽  
Implantable Cardioverter Defibrillator ◽  
Left Lung ◽  
Spect Imaging ◽  
Cardiac Innervation ◽  
Cardiac Spect ◽  
Cardioverter Defibrillator ◽  
Planar Images ◽  
Spect Images

Abstract Objective Impaired cardiac adrenergic activity has been demonstrated in heart failure (HF) and in diabetes mellitus (DM). [123I]I-metaiodobenzylguanidine (MIBG) enables assessment of the cardiac adrenergic nervous system. Tomographic imaging of the heart is expected to be superior to planar imaging. This study aimed to determine the quality and utility of MIBG SPECT in the assessment of cardiac innervation in postinfarction HF patients without DM, qualified for implantable cardioverter defibrillator (ICD) in primary prevention of sudden cardiac death. Methods Consecutive patients receiving an ICD on the basis of contemporary guidelines were prospectively included. Planar MIBG studies were followed by SPECT. The essential analysis was based on visual assessment of the quality of SPECT images (“high”, “low” or “unacceptable”). The variables used in the further analysis were late summed defect score for SPECT images and heart-to-mediastinum rate for planar images. MIBG images were assessed independently by two experienced readers. Results Fifty postinfarction nondiabetic HF subjects were enrolled. In 13 patients (26%), the assessment of SPECT studies was impossible. In addition, in 13 of 37 patients who underwent semiquantitative SPECT evaluation, the assessment was equivocal. Altogether, in 26/50 patients (52%, 95% confidence interval 38–65%), the quality of SPECT images was unacceptable or low and was limited by low MIBG cardiac uptake and by comparatively high, interfering MIBG uptake in the neighboring structures (primarily, in the lungs). Conclusions The utility of MIBG SPECT imaging, at least with conventional imaging protocols, in the qualification of postinfarction HF patients for ICD, is limited. In approximately half of the postinfarction HF patients, SPECT assessment of cardiac innervation can be impossible or equivocal, even without additional damage from diabetic cardiac neuropathy. The criteria predisposing the patient to good-quality MIBG SPECT are: high values of LVEF from the range characterizing the patients qualified to ICD (i.e., close to 35%) and left lung uptake intensity in planar images comparable to or lower than heart uptake.

An analytical approach for compensation of non-uniform attenuation in cardiac SPECT imaging

1995 ◽  
Vol 40 (10) ◽  
pp. 1677-1693 ◽  
Author(s):  
S J Glick ◽  
M A King ◽  
T -S Pan ◽  
E J Soares
Keyword(s):  
Analytical Approach ◽  
Spect Imaging ◽  
Cardiac Spect

C-reactive protein levels are associated with paraoxonase polymorphism L55M in patients undergoing cardiac SPECT imaging

2011 ◽  
Vol 71 (3) ◽  
pp. 179-184 ◽  
Author(s):  
Wanda Acampa ◽  
Maria D. Di Taranto ◽  
Alberto Morgante ◽  
Barbara Salvatore ◽  
Laura Evangelista ◽  
...  
Keyword(s):  
Spect Imaging ◽  
Cardiac Spect ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein
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