Experimental and theoretical x-ray imaging performance comparison of iodine and lanthanide contrast agents

1993 ◽  
Vol 20 (1) ◽  
pp. 15-31 ◽  
Author(s):  
H. Neale Cardinal ◽  
David W. Holdsworth ◽  
M. Drangova ◽  
Barry B. Hobbs ◽  
Aaron Fenster
Keyword(s):  
Contrast Agents ◽  
Performance Comparison ◽  
X Ray ◽  
X Ray Imaging ◽  
Imaging Performance

scholarly journals Image Segmentation Techniques in Bone Structure Psychiatry

2020 ◽  
Vol 9 (07) ◽  
pp. 25102-25112
Author(s):  
Ajayi Olayinka Adedoyin ◽  
Olamide Timothy Tawose ◽  
Olu Sunday Adetolaju
Keyword(s):  
Image Segmentation ◽  
Bone Structure ◽  
Performance Comparison ◽  
Imaging Systems ◽  
Intrinsic Properties ◽  
X Ray ◽  
Practical Applications ◽  
X Ray Imaging ◽  
Segmentation Algorithms ◽  
Bone Structures

Today, a large number of x-ray images are interpreted in hospitals and computer-aided system that can perform some intelligent task and analysis is needed in order to raise the accuracy and bring down the miss rate in hospitals, particularly when it comes to diagnosis of hairline fractures and fissures in bone joints. This research considered some segmentation techniques that have been used in the processing and analysis of medical images and a system design was proposed to efficiently compare these techniques. The designed system was tested successfully on a hand X-ray image which led to the proposal of simple techniques to eliminate intrinsic properties of x-ray imaging systems such as noise. The performance and accuracy of image segmentation techniques in bone structures were compared and these eliminated time wasting on the choice of image segmentation algorithms. Although there are several practical applications of image segmentation such as content-based image retrieval, machine vision, medical imaging, object detection, recognition tasks, etc., this study focuses on the performance comparison of several image segmentation techniques for medical X-ray images.

scholarly journals Imaging Performance of a Multimodal Module to Enhance Preclinical Irradiator Capabilities

2020 ◽  
pp. 1-4
Author(s):  
Sophie Pinel ◽  
Joël Daouk ◽  
Justine Jubréaux ◽  
Alicia Chateau ◽  
Hervé Schohn ◽  
...  
Keyword(s):  
Performance Measurements ◽  
Radiographic Images ◽  
Image Guided Radiotherapy ◽  
X Ray ◽  
Optical Images ◽  
X Ray Imaging ◽  
Single Sensor ◽  
Overall Performance ◽  
Imaging Performance ◽  
Image Homogeneity

This article highlights the performance measurements of an optical device which aims at upgrading preclinical irradiators. The evaluated device allows acquiring X-ray as well as bioluminescence images with a single sensor. The latter consists of a supercooled camera equipped with a 1024x1024 charge coupling device (each element measuring 13x13µm²). X-ray imaging is feasible, thanks to a conversion phosphor screen. Phantom acquisitions revealed a spatial resolution of 2.5 line pairs per millimetre (0.2mm) for Xray imaging and between 0.4 and 0.7mm for bioluminescence images. Image homogeneity was 0.8 for radiographic images with preclinical imaging parameters and higher than 0.9 for optical images. For functional imaging, contrast to noise ratio (CNR) ranged from 1.3 (for contrast of 2:1 and 0.1s acquisition) up to 253 (for contrast of 32:1 and 5s acquisition). CNR was related to acquisition duration. The device’s overall performance revealed that it is suitable to upgrade existing irradiators and improve laboratory capabilities toward image-guided radiotherapy.

scholarly journals X-ray Scatter Imaging of Hepatocellular Carcinoma in a Mouse Model Using Nanoparticle Contrast Agents

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Danielle Rand ◽  
Zoltan Derdak ◽  
Rolf Carlson ◽  
Jack R. Wands ◽  
Christoph Rose-Petruck
Keyword(s):  
Hepatocellular Carcinoma ◽  
Mouse Model ◽  
Contrast Agents ◽  
Malignant Tumors ◽  
Detection Methods ◽  
X Rays ◽  
X Ray ◽  
Enhanced Sensitivity ◽  
X Ray Imaging

Abstract Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide and is almost uniformly fatal. Current methods of detection include ultrasound examination and imaging by CT scan or MRI; however, these techniques are problematic in terms of sensitivity and specificity and the detection of early tumors (<1 cm diameter) has proven elusive. Better, more specific and more sensitive detection methods are therefore urgently needed. Here we discuss the application of a newly developed x-ray imaging technique called Spatial Frequency Heterodyne Imaging (SFHI) for the early detection of HCC. SFHI uses x-rays scattered by an object to form an image and is more sensitive than conventional absorption-based x-radiography. We show that tissues labeled in vivo with gold nanoparticle contrast agents can be detected using SFHI. We also demonstrate that directed targeting and SFHI of HCC tumors in a mouse model is possible through the use of HCC-specific antibodies. The enhanced sensitivity of SFHI relative to currently available techniques enables the x-ray imaging of tumors that are just a few millimeters in diameter and substantially reduces the amount of nanoparticle contrast agent required for intravenous injection relative to absorption-based x-ray imaging.

Niosomes as carriers of radiopaque contrast agents for X-ray imaging

2000 ◽  
Vol 17 (2) ◽  
pp. 227-243 ◽  
Author(s):  
D. Muller, M. Foulon, B. Bonnemain,
Keyword(s):  
Contrast Agents ◽  
X Ray ◽  
X Ray Imaging

scholarly journals Gold Nanoparticle Contrast Agents in Advanced X-ray Imaging Technologies

Molecules ◽  
2013 ◽  
Vol 18 (5) ◽  
pp. 5858-5890 ◽  
Author(s):  
Sungsook Ahn ◽  
Sung Jung ◽  
Sang Lee
Keyword(s):  
Contrast Agents ◽  
Gold Nanoparticle ◽  
X Ray ◽  
Imaging Technologies ◽  
X Ray Imaging

Measurements of X-ray Imaging Performance of Granular Phosphors With Direct-Coupled CMOS Sensors

2008 ◽  
Vol 55 (3) ◽  
pp. 1338-1343 ◽  
Author(s):  
Min Kook Cho ◽  
Ho Kyung Kim ◽  
Thorsten Graeve ◽  
Seung Man Yun ◽  
Chang Hwy Lim ◽  
...  
Keyword(s):  
X Ray ◽  
X Ray Imaging ◽  
Cmos Sensors ◽  
Imaging Performance

scholarly journals X-Ray Imaging of Poly(Ethylene Glycol) Hydrogels Without Contrast Agents

2010 ◽  
Vol 16 (6) ◽  
pp. 1597-1600 ◽  
Author(s):  
Eric M. Brey ◽  
Alyssa Appel ◽  
Yu-Chieh Chiu ◽  
Zhong Zhong ◽  
Ming-Huei Cheng ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Contrast Agents ◽  
Poly Ethylene Glycol ◽  
X Ray ◽  
X Ray Imaging ◽  
Poly Ethylene

scholarly journals Nanophosphor-Based Contrast Agents for Spectral X-ray Imaging

Nanomaterials ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. 1092 ◽  
Author(s):  
Kevin Smith ◽  
Matthew Getzin ◽  
Josephine J. Garfield ◽  
Sanika Suvarnapathaki ◽  
Gulden Camci-Unal ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Ligand Exchange ◽  
Photon Counting ◽  
Tissue Imaging ◽  
Ct Guided ◽  
X Ray ◽  
X Ray Imaging ◽  
Deep Tissue Imaging ◽  
Water Dispersibility ◽  
Lower Contrast

Lanthanide-based nanophosphors (NPhs) are herein developed as contrast agents for spectral X-ray imaging, highlighting the chemical, macromolecular and structural differences derived from ligand exchange on computed tomography (CT) and solvent dispersibility. Taking advantage of the ability of spectral X-ray imaging with photon-counting detectors to perform image acquisition, analysis, and processing at different energy windows (bins), enhanced signal of our K-edge materials was derived, improving sensitivity of CT imaging, and differentiation between water, tumor-mimic phantoms, and contrast materials. Our results indicate that the most effective of our oleic acid-stabilized K-edge nanoparticles can achieve 2–4x higher contrast than the examined iodinated molecules, making them suitable for deep tissue imaging of tissues or tumors. On the other hand, ligand exchange yielding poly(acrylic acid)-stabilized K-edge nanoparticles allows for high dispersibility and homogeneity in water, but with a lower contrast due to the high density of the polymer grafted, unless further engineering is probed. This is the first well-defined study that manages to correlate NPh grafting density with CT numbers and water dispersibility, laying the groundwork for the development of the next generation CT-guided diagnostic and/or theranostic materials.

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