Use of regularized principal component analysis to model anatomical changes during head and neck radiation therapy for treatment adaptation and response assessment

2016 ◽  
Vol 43 (10) ◽  
pp. 5307-5319 ◽  
Author(s):  
Mikhail A. Chetvertkov ◽  
Farzan Siddiqui ◽  
Jinkoo Kim ◽  
Indrin Chetty ◽  
Akila Kumarasiri ◽  
...  
Keyword(s):  
Principal Component Analysis ◽  
Radiation Therapy ◽  
Head And Neck ◽  
Principal Component ◽  
Response Assessment ◽  
Component Analysis ◽  
Anatomical Changes ◽  
Head And Neck Radiation

SU-C-BRF-03: PCA Modeling of Anatomical Changes During Head and Neck Radiation Therapy

2014 ◽  
Vol 41 (6Part2) ◽  
pp. 97-97
Author(s):  
M Chetvertkov ◽  
J Kim ◽  
F Siddiqui ◽  
A Kumarasiri ◽  
I Chetty ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Head And Neck ◽  
Anatomical Changes ◽  
Head And Neck Radiation

scholarly journals A Principal Component of Quality of Life Measures Is Associated with Survival for Head and Neck Cancer Patients Treated with Radiation Therapy

Cancers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1155
Author(s):  
Mark Farrugia ◽  
Han Yu ◽  
Sung Jun Ma ◽  
Austin J. Iovoli ◽  
Kristopher Attwood ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Principal Component Analysis ◽  
Overall Survival ◽  
Radiation Therapy ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Principal Component ◽  
Post Treatment

Background: Health-related quality of life (HRQOL) metrics can be associated with survival in head and neck cancer (HNC); however, the impact of HRQOL recovery and the relevant HRQOL domains regarding outcome are unclear. Methods: Using a single-institution database, we retrospectively reviewed HNC patients treated with definitive or postoperative radiation therapy between 2013 and 2018. The recovery of individual HRQOL domains were determined by the ratio of the post-treatment to baseline scores. Univariate and Multivariate Cox regression were used to analyze survival outcomes. Principal component analysis was used to adjust for multicollinearity of HRQOL domains. Results: In 218 HNC patients who received radiation therapy, median follow-up was 24.8 months (interquartile range (IQR) 14.5–32.0). Principal component analysis evaluating the recovery of HRQOL domains revealed two independent principal components (PC), PC1 and PC2. PC1, which received contributions from the functional domains; physical (PF), role (RF), emotional (EF), cognitive (CF), and global health status (GQOL) was significantly associated with disease-free (HR = 0.77, 95% CI 0.61–0.98, p = 0.034) and overall survival (HR = 0.76, 95% CI 0.65–0.91, p = 0.004) on multivariate analysis and PC2, had no correlation with outcome and was mainly represented by social functioning. Unplanned hospitalization was significantly associated with lower PC1 scores (β = −0.997, Std. Error = 0.244, p < 0.001). Conclusion: Our study provides evidence that post-treatment recovery of HRQOL domains were associated with overall survival (OS) in HNC. PC1 is an attractive clinical tool to assess the recovery across multiple different HRQOL and the relationship with survival. Future prospective studies may identify patients who could benefit from additional rehabilitation based on PC1 score.

Principal component analysis modeling of Head‐and‐Neck anatomy using daily Cone Beam‐CT images

2018 ◽  
Vol 45 (12) ◽  
pp. 5366-5375 ◽  
Author(s):  
Panagiotis Tsiamas ◽  
Hassan Bagher‐Ebadian ◽  
Farzan Siddiqui ◽  
Chang Liu ◽  
Christian A. Hvid ◽  
...  
Keyword(s):  
Principal Component Analysis ◽  
Head And Neck ◽  
Cone Beam Ct ◽  
Principal Component ◽  
Component Analysis ◽  
Ct Images ◽  
Cone Beam ◽  
Neck Anatomy ◽  
Principal Component Analysis Modeling

A German version of the Intermittent Claudication Questionnaire (ICQ): cultural adaptation and validation

VASA ◽  
2012 ◽  
Vol 41 (5) ◽  
pp. 333-342 ◽  
Author(s):  
Kirchberger ◽  
Finger ◽  
Müller-Bühl
Keyword(s):  
Principal Component Analysis ◽  
Intermittent Claudication ◽  
Completion Time ◽  
Short Form ◽  
Principal Component ◽  
Component Analysis ◽  
German Version ◽  
Average Completion Time ◽  
Sf 36 ◽  
Related Quality

Background: The Intermittent Claudication Questionnaire (ICQ) is a short questionnaire for the assessment of health-related quality of life (HRQOL) in patients with intermittent claudication (IC). The objective of this study was to translate the ICQ into German and to investigate the psychometric properties of the German ICQ version in patients with IC. Patients and methods: The original English version was translated using a forward-backward method. The resulting German version was reviewed by the author of the original version and an experienced clinician. Finally, it was tested for clarity with 5 German patients with IC. A sample of 81 patients were administered the German ICQ. The sample consisted of 58.0 % male patients with a median age of 71 years and a median IC duration of 36 months. Test of feasibility included completeness of questionnaires, completion time, and ratings of clarity, length and relevance. Reliability was assessed through a retest in 13 patients at 14 days, and analysis of Cronbach’s alpha for internal consistency. Construct validity was investigated using principal component analysis. Concurrent validity was assessed by correlating the ICQ scores with the Short Form 36 Health Survey (SF-36) as well as clinical measures. Results: The ICQ was completely filled in by 73 subjects (90.1 %) with an average completion time of 6.3 minutes. Cronbach’s alpha coefficient reached 0.75. Intra-class correlation for test-retest reliability was r = 0.88. Principal component analysis resulted in a 3 factor solution. The first factor explained 51.5 of the total variation and all items had loadings of at least 0.65 on it. The ICQ was significantly associated with the SF-36 and treadmill-walking distances whereas no association was found for resting ABPI. Conclusions: The German version of the ICQ demonstrated good feasibility, satisfactory reliability and good validity. Responsiveness should be investigated in further validation studies.

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