TH-CD-209-02: Beam Angle Optimization Incorporating Anatomical Heterogeneities for Pencil Beam Scanning Charged-Particle Therapy

2016 ◽  
Vol 43 (6Part46) ◽  
pp. 3886-3886
Author(s):  
C Toramatsu ◽  
T Inaniwa
Keyword(s):  
Charged Particle ◽  
Particle Therapy ◽  
Pencil Beam ◽  
Beam Angle ◽  
Beam Scanning ◽  
Pencil Beam Scanning ◽  
Beam Angle Optimization ◽  
Charged Particle Therapy

scholarly journals The potential of Gantry beamline large momentum acceptance for real time tumour tracking in pencil beam scanning proton therapy

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Giovanni Fattori ◽  
Ye Zhang ◽  
David Meer ◽  
Damien Charles Weber ◽  
Antony John Lomax ◽  
...  
Keyword(s):  
Proton Therapy ◽  
Hot Spots ◽  
Alternative Energy ◽  
Particle Therapy ◽  
Large Momentum ◽  
Energy Regulation ◽  
Pencil Beam ◽  
Beam Scanning ◽  
Pencil Beam Scanning ◽  
Momentum Acceptance

Abstract Tumour tracking is an advanced radiotherapy technique for precise treatment of tumours subject to organ motion. In this work, we addressed crucial aspects of dose delivery for its realisation in pencil beam scanning proton therapy, exploring the momentum acceptance and global achromaticity of a Gantry beamline to perform continuous energy regulation with a standard upstream degrader. This novel approach is validated on simulation data from three geometric phantoms of increasing complexity and one liver cancer patient using 4D dose calculations. Results from a standard high-to-low beamline ramping scheme were compared to alternative energy meandering schemes including combinations with rescanning. Target coverage and dose conformity were generally well recovered with tumour tracking even though for particularly small targets, large variations are reported for the different approaches. Meandering in energy while rescanning has a positive impact on target homogeneity and similarly, hot spots outside the targets are mitigated with a relatively fast convergence rate for most tracking scenarios, halving the volume of hot spots after as little as 3 rescans. This work investigates the yet unexplored potential of having a large momentum acceptance in medical beam line, and provides an alternative to take tumour tracking with particle therapy closer to clinical translation.

scholarly journals Impact of beam angle choice on pencil beam scanning breath-hold proton therapy for lung lesions

2017 ◽  
Vol 56 (6) ◽  
pp. 853-859 ◽  
Author(s):  
Jenny Gorgisyan ◽  
Rosalind Perrin ◽  
Antony J. Lomax ◽  
Gitte F. Persson ◽  
Mirjana Josipovic ◽  
...  
Keyword(s):  
Proton Therapy ◽  
Breath Hold ◽  
Pencil Beam ◽  
Beam Angle ◽  
Beam Scanning ◽  
Lung Lesions ◽  
Pencil Beam Scanning

scholarly journals Silicon 3D Microdosimeters for Advanced Quality Assurance in Particle Therapy

2021 ◽  
Vol 12 (1) ◽  
pp. 328
Author(s):  
Linh T. Tran ◽  
David Bolst ◽  
Benjamin James ◽  
Vladimir Pan ◽  
James Vohradsky ◽  
...  
Keyword(s):  
High Dose Rate ◽  
Low Noise ◽  
Silicon On Insulator ◽  
Particle Therapy ◽  
High Dose ◽  
Pencil Beam ◽  
High Definition ◽  
Beam Scanning ◽  
Radiation Physics ◽  
Pencil Beam Scanning

The Centre for Medical Radiation Physics introduced the concept of Silicon On Insulator (SOI) microdosimeters with 3-Dimensional (3D) cylindrical sensitive volumes (SVs) mimicking the dimensions of cells in an array. Several designs of high-definition 3D SVs fabricated using 3D MEMS technology were implemented. 3D SVs were fabricated in different sizes and configurations with diameters between 18 and 30 µm, thicknesses of 2–50 µm and at a pitch of 50 µm in matrices with volumes of 20 × 20 and 50 × 50. SVs were segmented into sub-arrays to reduce capacitance and avoid pile up in high-dose rate pencil beam scanning applications. Detailed TCAD simulations and charge collection studies in individual SVs have been performed. The microdosimetry probe (MicroPlus) is composed of the silicon microdosimeter and low-noise front–end readout electronics housed in a PMMA waterproof sheath that allows measurements of lineal energies as low as 0.4 keV/µm in water or PMMA. Microdosimetric quantities measured with SOI microdosimeters and the MicroPlus probe were used to evaluate the relative biological effectiveness (RBE) of heavy ions and protons delivered by pencil-beam scanning and passive scattering systems in different particle therapy centres. The 3D detectors and MicroPlus probe developed for microdosimetry have the potential to provide confidence in the delivery of RBE optimized particle therapy when introduced into routine clinical practice.

Reformatted method for two-dimensional detector arrays measurement data in proton pencil beam scanning

2021 ◽  
Vol 32 (6) ◽  
Author(s):  
Meng-Ya Guo ◽  
Xiu-Fang Li ◽  
Jie Wang ◽  
Qi Liu ◽  
Xiu-Zhen Deng ◽  
...  
Keyword(s):  
Measurement Data ◽  
Pencil Beam ◽  
Two Dimensional ◽  
Beam Scanning ◽  
Detector Arrays ◽  
Pencil Beam Scanning

scholarly journals Commissioning of a clinical pencil beam scanning proton therapy unit for ultra‐high dose rates (FLASH)

2021 ◽  
Author(s):  
Konrad P. Nesteruk ◽  
Michele Togno ◽  
Martin Grossmann ◽  
Anthony J. Lomax ◽  
Damien C. Weber ◽  
...  
Keyword(s):  
Proton Therapy ◽  
High Dose ◽  
Pencil Beam ◽  
Beam Scanning ◽  
Dose Rates ◽  
Pencil Beam Scanning

scholarly journals Characterization of passive dosimeters in proton pencil beam scanning – A EURADOS intercomparison for mailed dosimetry audits in proton therapy centres

2021 ◽  
Vol 82 ◽  
pp. 134-143
Author(s):  
M. De Saint-Hubert ◽  
C. De Angelis ◽  
Ž. Knežević ◽  
B. Michalec ◽  
B. Reniers ◽  
...  
Keyword(s):  
Proton Therapy ◽  
Pencil Beam ◽  
Beam Scanning ◽  
Pencil Beam Scanning
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