SU-G-TeP2-13: Patient-Specific Reduction of Range Uncertainties in Proton Therapy by Proton Radiography with a Multi-Layer Ionization Chamber

2016 ◽  
Vol 43 (6Part27) ◽  
pp. 3665-3666
Author(s):  
S Deffet ◽  
P Farace ◽  
R Righetto ◽  
B Macq ◽  
F Vander Stappen
Keyword(s):  
Proton Therapy ◽  
Ionization Chamber ◽  
Patient Specific ◽  
Proton Radiography

scholarly journals Patient-specific stopping power calibration for proton therapy planning based on single-detector proton radiography

2015 ◽  
Vol 60 (5) ◽  
pp. 1901-1917 ◽  
Author(s):  
P J Doolan ◽  
M Testa ◽  
G Sharp ◽  
E H Bentefour ◽  
G Royle ◽  
...  
Keyword(s):  
Proton Therapy ◽  
Stopping Power ◽  
Patient Specific ◽  
Therapy Planning ◽  
Proton Radiography ◽  
Single Detector

scholarly journals An Integrated Framework Based on Full Monte Carlo Simulations for Double-Scattering Proton Therapy

2019 ◽  
Vol 6 (2) ◽  
pp. 31-41
Author(s):  
Jiankui Yuan ◽  
David Mansur ◽  
Min Yao ◽  
Tithi Biswas ◽  
Yiran Zheng ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Proton Therapy ◽  
Treatment Plan ◽  
Planning System ◽  
Treatment Planning System ◽  
Patient Specific ◽  
Double Scattering ◽  
Integrated Framework ◽  
End To End ◽  
Clinical Cases

ABSTRACT Purpose: We developed an integrated framework that employs a full Monte Carlo (MC) model for treatment-plan simulations of a passive double-scattering proton system. Materials and Methods: We have previously validated a virtual machine source model for full MC proton-dose calculations by comparing the percentage of depth-dose curves, spread-out Bragg peaks, and lateral profiles against measured commissioning data. This study further expanded our previous work by developing an integrate framework that facilitates its clinical use. Specifically, we have (1) constructed patient-specific applicator and compensator numerically from the plan data and incorporated them into the beamline, (2) created the patient anatomy from the computed tomography image and established the transformation between patient and machine coordinate systems, and (3) developed a graphical user interface to ease the whole process from importing the treatment plan in the Digital Imaging and Communications in Medicine format to parallelization of the MC calculations. End-to-end tests were performed to validate the functionality, and 3 clinical cases were used to demonstrate clinical utility of the framework. Results: The end-to-end tests demonstrated that the framework functioned correctly for all tested functionality. Comparisons between the treatment planning system calculations and MC results in 3 clinical cases revealed large dose difference up to 17%, especially in the beam penumbra and near the end of beam range. The discrepancy likely originates from a variety of sources, such as the dose algorithms, modeling of the beamline, and the dose metric. The agreement for other regions was acceptable. Conclusion: An integrated framework was developed for full MC simulations of double-scattering proton therapy. It can be a valuable tool for dose verification and plan evaluation.

scholarly journals Towards Effective and Efficient Patient-Specific Quality Assurance for Spot Scanning Proton Therapy

Cancers ◽  
2015 ◽  
Vol 7 (2) ◽  
pp. 631-647 ◽  
Author(s):  
X. Zhu ◽  
Yupeng Li ◽  
Dennis Mackin ◽  
Heng Li ◽  
Falk Poenisch ◽  
...  
Keyword(s):  
Quality Assurance ◽  
Proton Therapy ◽  
Patient Specific ◽  
Spot Scanning

scholarly journals Proton therapy for non-squamous cell carcinoma of the head and neck: planning comparison and toxicity

2019 ◽  
Vol 60 (5) ◽  
pp. 612-621 ◽  
Author(s):  
Hiromitsu Iwata ◽  
Toshiyuki Toshito ◽  
Kensuke Hayashi ◽  
Maho Yamada ◽  
Chihiro Omachi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Proton Therapy ◽  
Patient Specific ◽  
Dose Distributions

Abstract To investigate optimal treatment planning using proton beams for non-squamous cell carcinoma of the head and neck (NSCHN), the dose distributions of plans involving pencil beam scanning (PBS) with or without a patient-specific aperture system (PSAS), passive-scattering proton therapy (PSPT) and X-ray intensity-modulated radiotherapy (IMRT) were compared. As clinical results, toxicities of PBS with PSAS, including changes in quality of life, were reported. Between April 2014 and August 2016, a total of 30 patients were treated using PBS with PSAS. In 20 patients selected at random, the dose distributions of PBS with or without the PSAS, PSPT and IMRT plans were compared. Neutron exposure by proton therapy was calculated using a Monte Carlo simulation. Toxicities were scored according to CTCAE ver. 4.0. Patients completed EORTC quality of life survey forms (QLQ-C30 and QLQ-HN35) before and 0–12 months after proton therapy. The 95% conformity number of PBS with the PSAS plan was the best, and significant differences were detected among the four plans (P < 0.05, Bonferroni tests). Neutron generation by PSAS was ~1.1-fold higher, but was within an acceptable level. No grade 3 or higher acute dermatitis was observed. Pain, appetite loss and increased weight loss were more likely at the end of treatment, but recovered by the 3 month follow-up and returned to the pretreatment level at the 12 month follow-up. PBS with PSAS reduced the penumbra and improved dose conformity in the planning target volume. PBS with PSAS was tolerated well for NSCHN.

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