SU-F-T-559: High-Resolution Scintillating Fiber Array for In-Vivo Real-Time SRS and SBRT Patient QA

2016 ◽  
Vol 43 (6Part21) ◽  
pp. 3591-3592
Author(s):  
T Knewtson ◽  
S Pokhrel ◽  
S Loyalka ◽  
E Izaguirre
Keyword(s):  
High Resolution ◽  
Real Time ◽  
Fiber Array ◽  
Scintillating Fiber

WE-AB-BRB-09: Real Time In Vivo Scintillating Fiber Array Detector for Medical LINACS

2015 ◽  
Vol 42 (6Part36) ◽  
pp. 3651-3651 ◽  
Author(s):  
T Knewtson ◽  
S Pokhrel ◽  
D Hernandez-Morales ◽  
S Price ◽  
S Loyalka ◽  
...  
Keyword(s):  
Real Time ◽  
Array Detector ◽  
Fiber Array ◽  
Scintillating Fiber

ITVT-10. Using functional Ultrasound (fUS) for real-time, depth-resolved functional and vascular delineation of brain tumors with micrometer-millisecond precision

2021 ◽  
Vol 23 (Supplement_6) ◽  
pp. vi230-vi230
Author(s):  
Sadaf Soloukey ◽  
Luuk Verhoef ◽  
Frits Mastik ◽  
Bastian Generowicz ◽  
Eelke Bos ◽  
...  
Keyword(s):  
High Resolution ◽  
Real Time ◽  
Cerebral Blood Volume ◽  
Imaging Technique ◽  
Power Doppler ◽  
Ease Of Use ◽  
Frame Rate ◽  
Neurosurgical Procedures ◽  
Vascular Morphology

Abstract BACKGROUND Neurosurgical practice still relies heavily on pre-operatively acquired images to guide tumor resections, a practice which comes with inherent pitfalls such as registration inaccuracy due to brain shift, and lack of real-time functional or morphological feedback. Here we describe functional Ultrasound (fUS) as a new high-resolution, depth-resolved, MRI/CT-registered imaging technique able to detect functional regions and vascular morphology during awake and anesthesized tumor resections. MATERIALS AND METHODS fUS relies on high-frame-rate (HFR) ultrasound, making the technique sensitive to very small motions caused by vascular dynamics (µDoppler) and allowing measurements of changes in cerebral blood volume (CBV) with micrometer-millisecond precision. This opens up the possibility to 1) detect functional response, as CBV-changes reflect changes in metabolism of activated neurons through neurovascular coupling, and 2) visualize in-vivo vascular morphology of pathological and healthy tissue with high resolution at unprecedented depths. During a range of anesthetized and awake neurosurgical procedures we acquired vascular and functional images of brain and spinal cord using conventional ultrasound probes connected to a research acquisition system. Building on Brainlab’s Intra-Operative Navigation modules, we co-registered our intra-operative Power Doppler Images (PDIs) to patient-registered MRI/CT-data in real-time. RESULTS During meningioma and glioma resections, our co-registered PDIs revealed fUS’ ability to visualize the tumor’s feeding vessels and vascular borders in real-time, with a level of detail unprecedented by conventional MRI-sequences. During awake resections, fUS was able to detect distinct, ESM-confirmed functional areas as activated during conventional motor and language tasks. In all cases, images were acquired with micrometer-millisecond (300 µm, 1.5–2.0 ms) precision at imaging depths exceeding 5 cm. CONCLUSION fUS is a new real-time, high-resolution and depth-resolved imaging technique, combining favorable imaging specifications with characteristics such as mobility and ease of use which are uniquely beneficial for a potential image-guided neurosurgical tool.

TU-F-BRE-01: A High Resolution Micro Fiber Scintillator Detector Optimized for SRS and SBRT in Vivo Real Time Treatment Verification

2014 ◽  
Vol 41 (6Part27) ◽  
pp. 468-468
Author(s):  
E Izaguirre ◽  
S Price ◽  
T Knewtson ◽  
S Loyalka ◽  
D Rangaraj
Keyword(s):  
High Resolution ◽  
Real Time ◽  
Treatment Verification ◽  
Time Treatment ◽  
Scintillator Detector

scholarly journals 3SDA-04 Real-time high-resolution cardiac imaging in vivo(3SDA Biophysics toward In Vivo work,Symposium)

2013 ◽  
Vol 53 (supplement1-2) ◽  
pp. S104
Author(s):  
Fuyu Kobirumaki-Shimozawa ◽  
Kotaro Oyama ◽  
Seine A. Shintani ◽  
Erisa Hirokawa ◽  
Togo Shimozawa ◽  
...  
Keyword(s):  
High Resolution ◽  
Real Time ◽  
Cardiac Imaging

scholarly journals High-Resolution in vivo Imaging of Xylem-Transported CO2 in Leaves Based on Real-Time 11C-Tracing

2019 ◽  
Vol 2 ◽  
Author(s):  
Michiel Hubeau ◽  
Michael R. Thorpe ◽  
Jens Mincke ◽  
Jasper Bloemen ◽  
Ingvar Bauweraerts ◽  
...  
Keyword(s):  
High Resolution ◽  
Real Time ◽  
In Vivo Imaging

Compound Scanning with a Phased Array

1982 ◽  
Vol 4 (2) ◽  
pp. 93-107 ◽  
Author(s):  
David P. Shattuck ◽  
Olaf T. von Ramm
Keyword(s):  
High Resolution ◽  
Real Time ◽  
Phased Array ◽  
Speckle Noise ◽  
Abdominal Imaging ◽  
Field Of View ◽  
Large Field ◽  
Grey Scale ◽  
Computer Controlled

Compound scans made with a dynamically focussed phased array system have been produced in real time. The scanner, intended for abdominal imaging, has a large field of view. The compounding improves the acquisition of echoes from specular targets by changing the orientation of the insonifying beam and also reduces the speckle noise in grey scale images. These gains are achieved while maintaining the high resolution and flexibility of a computer controlled phased array sector scanner. The configuration of the compound scanner is described, and in vivo abdominal scans are presented.

scholarly journals Real-Time High-Resolution MRI Endoscopy at up to 10 Frames per Second

BME Frontiers ◽  
2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Xiaoyang Liu ◽  
Parag Karmarkar ◽  
Dirk Voit ◽  
Jens Frahm ◽  
Clifford R. Weiss ◽  
...  
Keyword(s):  
High Resolution ◽  
Soft Tissue ◽  
Real Time ◽  
Large Animal ◽  
Motion Sensitivity ◽  
X Ray ◽  
High Resolution Mri ◽  
Endoscopy Ultrasound ◽  
Tissue Sensitivity

Objective. Atherosclerosis is a leading cause of mortality and morbidity. Optical endoscopy, ultrasound, and X-ray offer minimally invasive imaging assessments but have limited sensitivity for characterizing disease and therapeutic response. Magnetic resonance imaging (MRI) endoscopy is a newer idea employing tiny catheter-mounted detectors connected to the MRI scanner. It can see through vessel walls and provide soft-tissue sensitivity, but its slow imaging speed limits practical applications. Our goal is high-resolution MRI endoscopy with real-time imaging speeds comparable to existing modalities. Methods. Intravascular (3 mm) transmit-receive MRI endoscopes were fabricated for highly undersampled radial-projection MRI in a clinical 3-tesla MRI scanner. Iterative nonlinear reconstruction was accelerated using graphics processor units connected via a single ethernet cable to achieve true real-time endoscopy visualization at the scanner. MRI endoscopy was performed at 6-10 frames/sec and 200-300 μm resolution in human arterial specimens and porcine vessels ex vivo and in vivo and compared with fully sampled 0.3 frames/sec and three-dimensional reference scans using mutual information (MI) and structural similarity (3-SSIM) indices. Results. High-speed MRI endoscopy at 6-10 frames/sec was consistent with fully sampled MRI endoscopy and histology, with feasibility demonstrated in vivo in a large animal model. A 20-30-fold speed-up vs. 0.3 frames/sec reference scans came at a cost of ~7% in MI and ~45% in 3-SSIM, with reduced motion sensitivity. Conclusion. High-resolution MRI endoscopy can now be performed at frame rates comparable to those of X-ray and optical endoscopy and could provide an alternative to existing modalities, with MRI’s advantages of soft-tissue sensitivity and lack of ionizing radiation.

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