SU-F-T-201: Acceleration of Dose Optimization Process Using Dual-Loop Optimization Technique for Spot Scanning Proton Therapy

2016 ◽  
Vol 43 (6Part15) ◽  
pp. 3508-3508
Author(s):  
S Hirayama ◽  
R Fujimoto
Keyword(s):  
Proton Therapy ◽  
Optimization Technique ◽  
Optimization Process ◽  
Dose Optimization ◽  
Loop Optimization ◽  
Spot Scanning

scholarly journals A Review of the Robust Optimization Process and Advances with Monte Carlo in the Proton Therapy Management of Head and Neck Tumors

2021 ◽  
Vol 8 (1) ◽  
pp. 14-24
Author(s):  
Xiaodong Zhang
Keyword(s):  
Robust Optimization ◽  
Proton Therapy ◽  
Biological Effects ◽  
Optimization Technique ◽  
Dose Calculation ◽  
Optimization Process ◽  
Adaptive Planning ◽  
Intensity Modulated Proton Therapy ◽  
Neck Tumors ◽  
The Impact

Abstract In intensity-modulated proton therapy, robust optimization processes have been developed to manage uncertainties associated with (1) range, (2) setup, (3) anatomic changes, (4) dose calculation, and (5) biological effects. Here we review our experience using a robust optimization technique that directly incorporates range and setup uncertainties into the optimization process to manage those sources of uncertainty. We also review procedures for implementing adaptive planning to manage the anatomic uncertainties. Finally, we share some early experiences regarding the impact of uncertainties in dose calculation and biological effects, along with techniques to manage and potentially reduce these uncertainties.

scholarly journals Empirical quenching correction in radiochromic silicone-based three-dimensional dosimetry of spot-scanning proton therapy

2021 ◽  
Vol 18 ◽  
pp. 11-18
Author(s):  
Lia Barbosa Valdetaro ◽  
Ellen Marie Høye ◽  
Peter Sandegaard Skyt ◽  
Jørgen Breede Baltzer Petersen ◽  
Peter Balling ◽  
...  
Keyword(s):  
Proton Therapy ◽  
Three Dimensional ◽  
Spot Scanning

scholarly journals Spot scanning proton therapy minimizes neutron dose in the setting of radiation therapy administered during pregnancy

2016 ◽  
Vol 17 (5) ◽  
pp. 366-376 ◽  
Author(s):  
Xin Wang ◽  
Falk Poenisch ◽  
Narayan Sahoo ◽  
Ronald X. Zhu ◽  
MingFwu Lii ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Proton Therapy ◽  
Neutron Dose ◽  
Spot Scanning

PO-1417: A GPU Monte Carlo to support clinical routine in a compact spot scanning proton therapy system

2020 ◽  
Vol 152 ◽  
pp. S752-S753
Author(s):  
J. Gajewski ◽  
A. Schiavi ◽  
N. Krah ◽  
V. Patera ◽  
G. Vilches-Freixas ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Proton Therapy ◽  
Clinical Routine ◽  
Spot Scanning

scholarly journals Clinical Implementation of Proton Therapy Using Pencil-Beam Scanning Delivery Combined With Static Apertures

2021 ◽  
Vol 11 ◽  
Author(s):  
Christian Bäumer ◽  
Sandija Plaude ◽  
Dalia Ahmad Khalil ◽  
Dirk Geismar ◽  
Paul-Heinz Kramer ◽  
...  
Keyword(s):  
At Risk ◽  
Proton Therapy ◽  
Target Volume ◽  
Delivery Mode ◽  
Pencil Beam ◽  
Clinical Implementation ◽  
Beam Scanning ◽  
Pencil Beam Scanning ◽  
Spot Scanning ◽  
The Mean

Proton therapy makes use of the favorable depth-dose distribution with its characteristic Bragg peak to spare normal tissue distal of the target volume. A steep dose gradient would be desired in lateral dimensions, too. The widespread spot scanning delivery technique is based, however, on pencil-beams with in-air spot full-widths-at-half-maximum of typically 1 cm or more. This hampers the sparing of organs-at-risk if small-scale structures adjacent to the target volume are concerned. The trimming of spot scanning fields with collimating apertures constitutes a simple measure to increase the transversal dose gradient. The current study describes the clinical implementation of brass apertures in conjunction with the pencil-beam scanning delivery mode at a horizontal, clinical treatment head based on commercial hardware and software components. Furthermore, clinical cases, which comprised craniopharyngiomas, re-irradiations and ocular tumors, were evaluated. The dosimetric benefits of 31 treatment plans using apertures were compared to the corresponding plans without aperture. Furthermore, an overview of the radiation protection aspects is given. Regarding the results, robust optimization considering range and setup uncertainties was combined with apertures. The treatment plan optimizations followed a single-field uniform dose or a restricted multi-field optimization approach. Robustness evaluation was expanded to account for possible deviations of the center of the pencil-beam delivery and the mechanical center of the aperture holder. Supplementary apertures improved the conformity index on average by 15.3%. The volume of the dose gradient surrounding the PTV (evaluated between 80 and 20% dose levels) was decreased on average by 17.6%. The mean dose of the hippocampi could be reduced on average by 2.9 GyRBE. In particular cases the apertures facilitated a sparing of an organ-at-risk, e.g. the eye lens or the brainstem. For six craniopharyngioma cases the inclusion of apertures led to a reduction of the mean dose of 1.5 GyRBE (13%) for the brain and 3.1 GyRBE (16%) for the hippocampi.

scholarly journals Quality assurance evaluation of spot scanning beam proton therapy with an anthropomorphic prostate phantom

2013 ◽  
Vol 86 (1031) ◽  
pp. 20130390 ◽  
Author(s):  
K Iqbal ◽  
M Gillin ◽  
P A Summers ◽  
S Dhanesar ◽  
K A Gifford ◽  
...  
Keyword(s):  
Quality Assurance ◽  
Proton Therapy ◽  
Scanning Beam ◽  
Spot Scanning ◽  
Beam Proton

scholarly journals Towards Effective and Efficient Patient-Specific Quality Assurance for Spot Scanning Proton Therapy

Cancers ◽  
2015 ◽  
Vol 7 (2) ◽  
pp. 631-647 ◽  
Author(s):  
X. Zhu ◽  
Yupeng Li ◽  
Dennis Mackin ◽  
Heng Li ◽  
Falk Poenisch ◽  
...  
Keyword(s):  
Quality Assurance ◽  
Proton Therapy ◽  
Patient Specific ◽  
Spot Scanning
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