SU-F-T-133: Uniform Scanning Proton Therapy for Lung Cancer: Toxicity and Its Correlation with Dosimetry

2016 ◽  
Vol 43 (6Part14) ◽  
pp. 3492-3492
Author(s):  
Y Zheng ◽  
S Rana ◽  
G Larson
2014 ◽  
Vol 39 (4) ◽  
pp. 212 ◽  
Author(s):  
Suresh Rana ◽  
Hilarie Simpson ◽  
Gary Larson ◽  
Yuanshui Zheng

2020 ◽  
Vol 152 ◽  
pp. S245
Author(s):  
L. Nenoff ◽  
C.O. Ribeiro ◽  
M. Matter ◽  
L. Hafner ◽  
A.C. Knopf ◽  
...  

2021 ◽  
Author(s):  
Shingo Hashimoto ◽  
Hiromitsu Iwata ◽  
Yukiko Hattori ◽  
Koichiro Nakajima ◽  
Kento Nomura ◽  
...  

Abstract Background:Interstitial pneumonia (IP) is a disease with a poor prognosis. In addition, IP patients are more likely to develop lung cancer. Since IP patients frequently develop toxicities during cancer treatment, minimally invasive cancer treatment is warranted for such patients to maintain their quality of life. This study retrospectively investigated the efficacy and safety of proton therapy (PT) for non-small cell lung cancer (NSCLC) in patients with IP.Methods:Twenty-nine NSCLC patients with IP were treated with PT between September 2013 and December 2019. The patients had stage IA to IIIB primary NSCLC. Ten of the 29 patients exhibited the usual interstitial pneumonia pattern. The prescribed dose was 66-74 Grays (relative biological effectiveness) in 10-37 fractions.Results:The median follow-up period was 17.4 months (interquartile range (IQR), 9.5–32.7). The median patient age was 77 years (IQR, 71–81). The median planning target volume was 112.0 ml (IQR, 56.1–246.3). The 2-year local control, progression-free survival, and overall survival rates were 77% (95% confidence interval: 34 to 94), 31% (13–50), and 50% (26–70), respectively. According to the Common Terminology Criteria for Adverse Events (version 4.0), grade 3 acute radiation pneumonitis (RP) was observed in 1 patient. Two patients developed grade 3 late RP, but no other patients experienced serious toxicities. The patients’ quality of life (European Organization for Research and Treatment of Cancer QLQ-C30 and QLQ-LC13 and SF-36) scores had not changed after 3 months.Conclusions:PT may safely control NSCLC without adversely affecting the daily lives of IP patients.


2021 ◽  
Vol 161 ◽  
pp. S132-S133
Author(s):  
L. Nenoff ◽  
M. Matter ◽  
E.J. Amaya ◽  
M. Josipovic ◽  
A. Knopf ◽  
...  
Keyword(s):  

2019 ◽  
Vol 132 ◽  
pp. 250-256 ◽  
Author(s):  
Leo Luo ◽  
John Cuaron ◽  
Lior Braunstein ◽  
Erin Gillespie ◽  
Atif Kahn ◽  
...  

2020 ◽  
Vol 13 (3) ◽  
pp. 230-237
Author(s):  
Yoshiro Ieko ◽  
Noriyuki Kadoya ◽  
Takayuki Kanai ◽  
Yujiro Nakajima ◽  
Kazuhiro Arai ◽  
...  

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