SU-F-I-20: Volumetric Reduction of the Corpus Callosum in Alzheimer's Disease and Mild Cognitive Impairment

2016 ◽  
Vol 43 (6Part7) ◽  
pp. 3391-3391
Author(s):  
R Juh ◽  
T Suh ◽  
J Han ◽  
C Kim ◽  
C Oh
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Corpus Callosum

Deformation-based Statistical Shape Analysis of the Corpus Callosum in Mild Cognitive Impairment and Alzheimer’s Disease

2018 ◽  
Vol 15 (12) ◽  
pp. 1151-1160 ◽  
Author(s):  
Zihan Jiang ◽  
Huilin Yang ◽  
Xiaoying Tang
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Corpus Callosum ◽  
Shape Analysis ◽  
Disease Assessment ◽  
Statistical Shape Analysis ◽  
Superior Part ◽  
Statistical Shape

Objective: In this study, we investigated the influence that the pathology of Alzheimer’s disease (AD) exerts upon the corpus callosum (CC) using a total of 325 mild cognitive impairment (MCI) subjects, 155 AD subjects, and 185 healthy control (HC) subjects. Method: Regionally-specific morphological CC abnormalities, as induced by AD, were quantified using a large deformation diffeomorphic metric curve mapping based statistical shape analysis pipeline. We also quantified the association between the CC shape phenotype and two cognitive measures; the Mini Mental State Examination (MMSE) and the Alzheimer’s Disease Assessment Scale-Cognitive Behavior Section (ADAS-cog). To identify AD-relevant areas, CC was sub-divided into three subregions; the genu, body, and splenium (gCC, bCC, and sCC). Results: We observed significant shape compressions in AD relative to that in HC, mainly concentrated on the superior part of CC, across all three sub-regions. The HC-vs-MCI shape abnormalities were also concentrated on the superior part, but mainly occurred on bCC and sCC. The significant MCI-vs-AD shape differences, however, were only detected in part of sCC. In the shape-cognition association, significant negative correlations to ADAS-cog were detected for shape deformations at regions belonging to gCC and sCC and significant positive correlations to MMSE at regions mainly belonging to sCC. Conclusion: Our results suggest that the callosal shape deformation patterns, especially those of sCC, linked tightly to the cognitive decline in AD, and are potentially a powerful biomarker for monitoring the progression of AD.

P2-181 Regionally specific atrophy of the corpus callosum in Alzheimer's disease and mild cognitive impairment

2004 ◽  
Vol 25 ◽  
pp. S278
Author(s):  
Paul Wang ◽  
Andrew J. Saykin ◽  
Laura A. Flashman ◽  
Heather A. Wishart ◽  
Laura A. Rabin ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Corpus Callosum

P1-341: Changes of bending angles of the corpus callosum in mild cognitive impairment and Alzheimer's disease patients

2008 ◽  
Vol 4 ◽  
pp. T319-T319
Author(s):  
Chan-Seung Chung ◽  
Jae-Hong Lee ◽  
Duk-Lyul Na ◽  
Doh Kwan Kim ◽  
Sang Yun Kim ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Corpus Callosum ◽  
Bending Angles

scholarly journals Corpus Callosum Atrophy Rate in Mild Cognitive Impairment and Prodromal Alzheimer's Disease

2015 ◽  
Vol 45 (3) ◽  
pp. 921-931 ◽  
Author(s):  
Sahar Elahi ◽  
Alvin H. Bachman ◽  
Sang Han Lee ◽  
John J. Sidtis ◽  
Babak A. Ardekani ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Corpus Callosum ◽  
Atrophy Rate ◽  
Prodromal Alzheimer’S Disease

Structural Changes of the Corpus Callosum in Mild Cognitive Impairment and Alzheimer’s Disease

2006 ◽  
Vol 21 (4) ◽  
pp. 215-220 ◽  
Author(s):  
Philipp A. Thomann ◽  
Torsten Wüstenberg ◽  
Johannes Pantel ◽  
Marco Essig ◽  
Johannes Schröder
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Corpus Callosum ◽  
Structural Changes
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