Technical Note: Dose gradients and prescription isodose in orthovoltage stereotactic radiosurgery

2016 ◽  
Vol 43 (5) ◽  
pp. 2072-2080 ◽  
Author(s):  
Jessica M. Fagerstrom ◽  
Edward T. Bender ◽  
Wesley S. Culberson
Keyword(s):  
Stereotactic Radiosurgery ◽  
Technical Note ◽  
Prescription Isodose

The dosimetric impact of the prescription isodose line (IDL) on the quality of robotic stereotactic radiosurgery (SRS) plans

2017 ◽  
Vol 44 (12) ◽  
pp. 6159-6165 ◽  
Author(s):  
Qianyi Xu ◽  
Jiajin Fan ◽  
Jimm Grimm ◽  
Tamara LaCouture ◽  
Sucha Asbell ◽  
...  
Keyword(s):  
Stereotactic Radiosurgery ◽  
Prescription Isodose

scholarly journals Technical note: Image guided internal fiducial placement for stereotactic radiosurgery (CyberKnife)

2011 ◽  
Vol 21 (1) ◽  
pp. 3 ◽  
Author(s):  
GovindarajanJanardan Mallarajapatna ◽  
SridharPapaiah Susheela ◽  
KumarGangadharaiah Kallur ◽  
NagarajKanakapura Ramanna ◽  
PrashantGuthlu Ramachandra ◽  
...  
Keyword(s):  
Stereotactic Radiosurgery ◽  
Technical Note ◽  
Image Guided

scholarly journals Benefit of dosimetry distribution for patients with brain metastases from non-small cell lung cancer by Cyberknife Stereotactic radiosurgery (SRS) system

2020 ◽  
Author(s):  
Xuyao YU ◽  
Yuwen Wang ◽  
Zhiyong Yuan ◽  
Hui Yu ◽  
Yongchun Song ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Brain Metastases ◽  
Small Cell Lung Cancer ◽  
Stereotactic Radiosurgery ◽  
Cell Lung Cancer ◽  
Treatment Time ◽  
Small Cell ◽  
Small Cell Lung ◽  
Multiple Lesions ◽  
Prescription Isodose

Abstract BackgroundTo pursue high precision in tumor and steeper dose fall-off in healthy tissues of brain metastases stereotactic radiosurgery (SRS), this study investigated an opitimized planning by comparison only one multiple-lesions-plan (MLP) and multiple single-lesion-plans (SLP) in the treatment of brain metastases using Cyberknife (CK) Robotic Radiosurgery System. MethodsFifty non-small cell lung cancer (NSCLC) patients (28 males and 22 females) with 2-4 multiple brain metastases were retrospectively replanned with 12 to 32 Gy prescription dose in 1 to 3 fractions. Two different clinical SRS plans (SLP and MLP) for the same patients were generated, under the same collimator and prescription isodose line (62-68%) by CK Multiplan System. Both the SLP and MLP were able to get ＞95% PTV volume covered prescription isodose and meet the Timmerman 2011 OAR (brainstem, optic nerve and pituitary) constraints.ResultsCompared with the SLP, the maximum dose (Dmax) and mean dose (Dmean) of brainstem in the MLP decreased 0.22-3.13% (2.62%) and 2.71-12.56% (5.57%), over all P＜0.05. While the volumes of whole brain minus the tumors received a single dose equivalence of 8-16Gy (V8Gy-V16Gy) could effectively reduce in the MLP. And the treatment time parameters (the total number of beams and monitor units (MU)) of the MLP declined 3.31% and 1.47% (P＜0.05) respectively. Although there were a few differences of conformity index (CI) and homogeneity index (HI) between two treatment plans, it was no statistical significance (P = 2.94 and 1.08＞ 0.05). ConclusionOne multiple-lesions-plan for brain metastases could achieve higher precision in target and lower dose in healthy tissue, while shorten the treatment time and improve the treatment efficiency.

Choosing a Prescription Isodose in Stereotactic Radiosurgery for Brain Metastases: Implications for Local Control

2017 ◽  
Vol 98 ◽  
pp. 761-767.e1 ◽  
Author(s):  
Kara D. Romano ◽  
Daniel M. Trifiletti ◽  
Allison Garda ◽  
Zhiyuan Xu ◽  
David Schlesinger ◽  
...  
Keyword(s):  
Brain Metastases ◽  
Stereotactic Radiosurgery ◽  
Local Control ◽  
Prescription Isodose

Investigation of the Optimal Prescription Isodose for Stereotactic Radiosurgery of Vestibular Schwannomas

2014 ◽  
Vol 90 (1) ◽  
pp. S893-S894
Author(s):  
T. Gevaert ◽  
M. Levivier ◽  
F. Steenbeke ◽  
B. Engels ◽  
C. Tuleasca ◽  
...  
Keyword(s):  
Stereotactic Radiosurgery ◽  
Vestibular Schwannomas ◽  
Prescription Isodose

Technical Note: Construction of heterogeneous head phantom for quality control in stereotactic radiosurgery

2017 ◽  
Vol 44 (10) ◽  
pp. 5070-5074 ◽  
Author(s):  
Mohsen Najafi ◽  
Javad Teimouri ◽  
Alireza Shirazi ◽  
Ghazale Geraily ◽  
Mahbod Esfahani ◽  
...  
Keyword(s):  
Quality Control ◽  
Stereotactic Radiosurgery ◽  
Technical Note

The Effect of Prescription Isodose Variation on Tumor Control and Toxicities in Stereotactic Radiosurgery for Sporadic Vestibular Schwannoma: Propensity Score-Matched Case–Control Study

2021 ◽  
Author(s):  
Achiraya Teyateeti ◽  
Christopher S. Graffeo ◽  
Avital Perry ◽  
Eric J. Tryggestad ◽  
Paul D. Brown ◽  
...  
Keyword(s):  
Propensity Score ◽  
Stereotactic Radiosurgery ◽  
Vestibular Schwannoma ◽  
Hearing Preservation ◽  
Tumor Control ◽  
Gamma Knife Stereotactic Radiosurgery ◽  
The Impact ◽  
Prescription Isodose

Abstract Objective Vestibular schwannoma (VS) treated with Gamma Knife stereotactic radiosurgery (SRS) was typically performed at 50% isodose line (IDL50); however, the impact of IDL variation on outcomes is poorly understood. This study aimed to compare tumor control (TC) and toxicities between treatment at 40% (IDL40) and 50% (IDL50). Methods and Materials Sporadic/unilateral VS patients treated with SRS dose 12 to 14 Gy and prescription isodose volume ≤10cm3 were included. Propensity score matching was applied to IDL40 cohort to generate an IDL50 companion cohort, adjusting for age and prescription isodose volume. After exclusion of patients with follow-up <24 months, there were 30 and 28 patients in IDL40 and IDL50 cohorts, respectively. Results Median follow-up time was 96 months (24–225 months). Actuarial and radiographic TC rates were 91.8% and clinical TC was 96.2% both at 5 and 10 years. TC was higher in IDL40 cohort but not significant (96.4 vs. 86.7%; p = 0.243). Hearing preservation (HP) rates were 71.9 and 39.2% at 5- and 10-year intervals, with significantly higher rates of HP noted in IDL40 cohort (83.3 vs. 57.1% at 5-year interval; 62.5 vs. 11.4% at 10-year interval; p = 0.017). Permanent facial neuropathy occurred in two patients, both from the IDL50 cohort (3.5%). Rates of post-SRS steroid treatment or shunt placement for hydrocephalus were slightly higher in IDL50 patients (6.9 vs. 17.9%; p = 0.208 and 3.3 vs. 7.1%; p = 0.532). Conclusion For treatment of VS with SRS, dose prescription at IDL40 or IDL50 provides excellent long-term TC and toxicity profiles. IDL40 may be associated with improved long-term HP.

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