scholarly journals Quantifying the performance of in vivo portal dosimetry in detecting four types of treatment parameter variations

2015 ◽  
Vol 42 (12) ◽  
pp. 6912-6918 ◽  
Author(s):  
C. Bojechko ◽  
E. C. Ford
Keyword(s):  
Portal Dosimetry ◽  
Treatment Parameter ◽  
Parameter Variations

Verification of treatment parameter transfer by means of electronic portal dosimetry

2004 ◽  
Vol 31 (2) ◽  
pp. 341-347 ◽  
Author(s):  
S. M. J. J. G. Nijsten ◽  
A. W. H. Minken ◽  
P. Lambin ◽  
I. A. D. Bruinvis
Keyword(s):  
Portal Dosimetry ◽  
Treatment Parameter

scholarly journals EP-1416: Classification of alerts observed during large scale in vivo portal dosimetry

2015 ◽  
Vol 115 ◽  
pp. S765
Author(s):  
A. Mans ◽  
R.A. Rozendaal ◽  
P. González ◽  
M. Van Herk ◽  
B.J. Mijnheer
Keyword(s):  
Large Scale ◽  
Portal Dosimetry

scholarly journals Calibration, Selection and Identifiability Analysis of a Mathematical Model of the in vitro Erythropoiesis in Normal and Perturbed Contexts

2018 ◽  
Author(s):  
Ronan Duchesne ◽  
Anissa Guillemin ◽  
Fabien Crauste ◽  
Olivier Gandrillon
Keyword(s):  
Mathematical Model ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Identifiability Analysis ◽  
The Past ◽  
Parameter Variations ◽  
Linear Ode ◽  
Kinetics Of

AbstractThe in vivo erythropoiesis, which is the generation of mature red blood cells in the bone marrow of whole organisms, has been described by a variety of mathematical models in the past decades. However, the in vitro erythropoiesis, which produces red blood cells in cultures, has received much less attention from the modelling community. In this paper, we propose the first mathematical model of in vitro erythropoiesis. We start by formulating different models and select the best one at fitting experimental data of in vitro erythropoietic differentiation. It is based on a set of linear ODE, describing 3 hypothetical populations of cells at different stages of differentiation. We then compute confidence intervals for all of its parameters estimates, and conclude that our model is fully identifiable. Finally, we use this model to compute the effect of a chemical drug called Rapamycin, which affects all states of differentiation in the culture, and relate these effects to specific parameter variations. We provide the first model for the kinetics of in vitro cellular differentiation which is proven to be identifiable. It will serve as a basis for a model which will better account for the variability which is inherent to experimental protocol used for the model calibration.

scholarly journals A repressor-decay timer for robust temporal patterning in embryonic Drosophila neuroblast lineages

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Inna Averbukh ◽  
Sen-Lin Lai ◽  
Chris Q Doe ◽  
Naama Barkai
Keyword(s):  
Neural Progenitors ◽  
Drosophila Embryo ◽  
High Temporal Resolution ◽  
Relative Importance ◽  
Robust Performance ◽  
Regulatory Circuit ◽  
Parameter Variations ◽  
Biological Circuits ◽  
Theory And Experiments

Biological timers synchronize patterning processes during embryonic development. In the Drosophila embryo, neural progenitors (neuroblasts; NBs) produce a sequence of unique neurons whose identities depend on the sequential expression of temporal transcription factors (TTFs). The stereotypy and precision of NB lineages indicate reproducible TTF timer progression. We combine theory and experiments to define the timer mechanism. The TTF timer is commonly described as a relay of activators, but its regulatory circuit is also consistent with a repressor-decay timer, where TTF expression begins when its repressor decays. Theory shows that repressor-decay timers are more robust to parameter variations than activator-relay timers. This motivated us to experimentally compare the relative importance of the relay and decay interactions in vivo. Comparing WT and mutant NBs at high temporal resolution, we show that the TTF sequence progresses primarily by repressor-decay. We suggest that need for robust performance shapes the evolutionary-selected designs of biological circuits.

Commissioning an aSi-EPID for in vivo Portal Dosimetry

2011 ◽  
Vol 23 (3) ◽  
pp. S52
Author(s):  
D.J. Shaw ◽  
D.W. Smith ◽  
P. Crean ◽  
P.A. Rixham ◽  
S.J. Weston ◽  
...  
Keyword(s):  
Portal Dosimetry

The Development of a New Type Dissolving Instrument of Gallstone

2010 ◽  
Vol 33 ◽  
pp. 92-95
Author(s):  
B.Q. Zhu ◽  
J.Q. Niu ◽  
Q.L. Jin ◽  
Z.L. Yu ◽  
C.H. Piao
Keyword(s):  
Software Design ◽  
High Speed ◽  
Rapid Development ◽  
Structure Design ◽  
Peristaltic Pumps ◽  
Treatment Parameter ◽  
New Type ◽  
Working Principle

With the rapid development of economic society, more and more people are suffering from the huge pressure that comes from all aspects. So many kinds of diseases have higher morbidity than before. Among these diseases gallstone is paid more attention because of its generality. To design a new type instrument that can dissolve cholesterin gallstone directly through peristaltic pumps controlled by industry compute and high speed Analog/Digital (A/D) and Digital/Analog (D/A) card. The instrument can regulate the amount of solvent automatically in order to adapt to the cholecyst according to the treatment parameter given by manipulator and the pressure of patients' cholecyst. Meanwhile, the date can be displayed on the screen. The working principle, structure design, hardware and software design have been presented in this paper. The instrument showed a good result both in vitro and in vivo for animals. These tests confirm that the instrument can enhance the efficiency of manual infusing to dissolve a stone and decrease the patients’ pain and sufferings, especially have more significance to the patients who aren't fit for operation and anesthesia. It has the advantages of quick treatment and micro hurt, fitting for clinic use. The new type instrument that can dissolve cholesterin gallstone is a kind of means that can be widespread used with micro hurt.

scholarly journals A repressor-decay timer for robust temporal patterning in embryonic Drosophila neuroblast lineages

2018 ◽  
Author(s):  
Inna Averbukh ◽  
Sen-Lin Lai ◽  
Chris Q. Doe ◽  
Naama Barkai
Keyword(s):  
Transcription Factors ◽  
Embryonic Development ◽  
Neural Progenitors ◽  
Evolutionary Design ◽  
Temporal Patterning ◽  
Regulatory Circuit ◽  
Parameter Variations ◽  
Theory And Experiments

AbstractBiological timers synchronize patterning processes during embryonic development. In the Drosophila embryo, neural progenitors (neuroblasts; NBs) produce a sequence of unique neurons whose identities depend on the sequential expression of temporal transcription factors (TTFs). The stereotypy and precision of the NB lineages indicate reproducible temporal progression of the TTF timer. To examine the basis of this robustness, we combine theory and experiments. The TTF timer is commonly described as a relay of activators, but its regulatory circuit is also consistent with a repressor-decay timer, in which expression of each TTF begins once its repressor is sufficiently reduced. We find that repressor-decay timers are more robust to parameter variations compared to activator-relay timers. This suggests that the in-vivo TTF sequence progresses primarily by repressor-decay, a prediction that we support experimentally. Our results emphasize the role of robustness in the evolutionary design of patterning circuits.

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