WE-EF-303-03: A New Aperture-Based Imaging System for Prompt-Gamma Range Verification of Proton Beam Therapy

2015 ◽  
Vol 42 (6Part39) ◽  
pp. 3678-3678
Author(s):  
J Ready ◽  
R Pak ◽  
L Mihailescu ◽  
K Vetter
Keyword(s):  
Proton Beam ◽  
Imaging System ◽  
Proton Beam Therapy ◽  
Prompt Gamma ◽  
Gamma Range ◽  
Range Verification

scholarly journals A New Method to Reconstruct in 3D the Emission Position of the Prompt Gamma Rays following Proton Beam Irradiation

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Costanza M. V. Panaino ◽  
Ranald I. Mackay ◽  
Karen J. Kirkby ◽  
Michael J. Taylor
Keyword(s):  
Proton Beam ◽  
Gamma Rays ◽  
Proton Beam Therapy ◽  
Peak Position ◽  
Prompt Gamma ◽  
Proton Beam Irradiation ◽  
Spot Scanning ◽  
Symmetrical Configuration ◽  
A New Technique ◽  
Range Verification

AbstractA new technique for range verification in proton beam therapy has been developed. It is based on the detection of the prompt γ rays that are emitted naturally during the delivery of the treatment. A spectrometer comprising 16 LaBr3(Ce) detectors in a symmetrical configuration is employed to record the prompt γ rays emitted along the proton path. An algorithm has been developed that takes as inputs the LaBr3(Ce) detector signals and reconstructs the maximum γ-ray intensity peak position, in full 3 dimensions. For a spectrometer radius of 8 cm, which could accommodate a paediatric head and neck case, the prompt γ-ray origin can be determined from the width of the detected peak with a σ of 4.17 mm for a 180 MeV proton beam impinging a water phantom. For spectrometer radii of 15 and 25 cm to accommodate larger volumes this value increases to 5.65 and 6.36 mm. For a 8 cm radius, with a 5 and 10 mm undershoot, the σ is 4.31 and 5.47 mm. These uncertainties are comparable to the range uncertainties incorporated in treatment planning. This work represents the first step towards a new accurate, real-time, 3D range verification device for spot-scanning proton beam therapy.

scholarly journals Experimental Study of Using a 3-D Position Sensitive CdZnTe Detector for Proton Beam Range Verification

2021 ◽  
Author(s):  
Valerie Nwadeyi ◽  
Paul maggi ◽  
Zhong He ◽  
Jerimy Polf
Keyword(s):  
Proton Beam ◽  
Expectation Maximization ◽  
Gamma Ray ◽  
Prompt Gamma ◽  
Cdznte Detector ◽  
Maximum Likelihood Expectation Maximization ◽  
Gamma Ray Imaging ◽  
Position Sensitive ◽  
Beam Range ◽  
Range Verification

This manuscript discusses the use of a large volume array CZT detector for experimental prompt gamma-ray imaging. Namely, the 718 keV and the 4.44 MeV photopeaks produced from proton-carbon interactions are imaged using maximum likelihood expectation maximization (MLEM). Various proton beam irradiations are used to characterize the feasibility of using both photopeaks for beam range verification.

Abstract ID: 171 A Monte Carlo study to reduce range uncertainty in proton beam therapy via prompt gamma-ray detection

2018 ◽  
Vol 45 ◽  
pp. S2 ◽  
Author(s):  
C. Panaino ◽  
M.J. Taylor ◽  
R. MacKay ◽  
M.J. Merchant ◽  
T. Price ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Proton Beam ◽  
Gamma Ray ◽  
Monte Carlo Study ◽  
Proton Beam Therapy ◽  
Prompt Gamma

WE-D-BRF-03: Proton Beam Range Verification with a Single Prompt Gamma-Ray Detector

2014 ◽  
Vol 41 (6Part29) ◽  
pp. 495-495
Author(s):  
J Verburg ◽  
M Testa ◽  
E Cascio ◽  
T Bortfeld ◽  
H Lu ◽  
...  
Keyword(s):  
Proton Beam ◽  
Gamma Ray ◽  
Prompt Gamma ◽  
Gamma Ray Detector ◽  
Beam Range ◽  
Range Verification

OC-0698: First-in-man validation of CT-based stopping-power prediction using prompt-gamma range verification

2020 ◽  
Vol 152 ◽  
pp. S390-S391
Author(s):  
J. Berthold ◽  
C. Khamfongkhruea ◽  
A. Jost ◽  
J. Petzoldt ◽  
J. Thiele ◽  
...  
Keyword(s):  
Stopping Power ◽  
Prompt Gamma ◽  
Power Prediction ◽  
Gamma Range ◽  
Range Verification

scholarly journals Experimental Study of Using a 3-D Position Sensitive CdZnTe Detector for Proton Beam Range Verification

2021 ◽  
Author(s):  
Valerie Nwadeyi ◽  
Paul maggi ◽  
Zhong He ◽  
Jerimy Polf
Keyword(s):  
Proton Beam ◽  
Expectation Maximization ◽  
Gamma Ray ◽  
Prompt Gamma ◽  
Cdznte Detector ◽  
Maximum Likelihood Expectation Maximization ◽  
Gamma Ray Imaging ◽  
Position Sensitive ◽  
Beam Range ◽  
Range Verification

This manuscript discusses the use of a large volume array CZT detector for experimental prompt gamma-ray imaging. Namely, the 718 keV and the 4.44 MeV photopeaks produced from proton-carbon interactions are imaged using maximum likelihood expectation maximization (MLEM). Various proton beam irradiations are used to characterize the feasibility of using both photopeaks for beam range verification.

scholarly journals On-line range verification for proton beam therapy using spherical ionoacoustic waves with resonant frequency

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Taisuke Takayanagi ◽  
Tomoki Uesaka ◽  
Yuta Nakamura ◽  
Mehmet Burcin Unlu ◽  
Yasutoshi Kuriyama ◽  
...  
Keyword(s):  
Resonant Frequency ◽  
Proton Beam ◽  
Patient Positioning ◽  
Proton Beam Therapy ◽  
Simulation Studies ◽  
Clinical Dose ◽  
On Line ◽  
Verification Methodology ◽  
Beam Range ◽  
Range Verification

AbstractIn contrast to conventional X-ray therapy, proton beam therapy (PBT) can confine radiation doses to tumours because of the presence of the Bragg peak. However, the precision of the treatment is currently limited by the uncertainty in the beam range. Recently, a unique range verification methodology has been proposed based on simulation studies that exploit spherical ionoacoustic waves with resonant frequency (SPIREs). SPIREs are emitted from spherical gold markers in tumours initially introduced for accurate patient positioning when the proton beam is injected. These waves have a remarkable property: their amplitude is linearly correlated with the residual beam range at the marker position. Here, we present proof-of-principle experiments using short-pulsed proton beams at the clinical dose to demonstrate the feasibility of using SPIREs for beam-range verification with submillimetre accuracy. These results should substantially contribute to reducing the range uncertainty in future PBT applications.

scholarly journals 3D prompt gamma imaging for proton beam range verification

2018 ◽  
Vol 63 (3) ◽  
pp. 035019 ◽  
Author(s):  
E Draeger ◽  
D Mackin ◽  
S Peterson ◽  
H Chen ◽  
S Avery ◽  
...  
Keyword(s):  
Proton Beam ◽  
Prompt Gamma ◽  
Gamma Imaging ◽  
Prompt Gamma Imaging ◽  
Beam Range ◽  
Range Verification

scholarly journals Experimental Study of Using a 3-D Position Sensitive CdZnTe Detector for Proton Beam Range Verification

2021 ◽  
Author(s):  
Valerie Nwadeyi ◽  
Paul maggi ◽  
Zhong He ◽  
Jerimy Polf
Keyword(s):  
Proton Beam ◽  
Gamma Ray ◽  
Incident Angle ◽  
Prompt Gamma ◽  
Compton Imaging ◽  
Cdznte Detector ◽  
Maximum Likelihood Expectation Maximization ◽  
Position Sensitive ◽  
Beam Range ◽  
Range Verification

<p><i>Position sensitive CdZnTe Compton imaging cameras are currently being studied for their use of proton beam range verification for radiotherapy applications. This work presents the use of an experimental large volume CdZnTe detector for the detection of prompt gamma rays that are emitted from proton-nuclei interaction within plastic (C2H4) targets. Two experiments were conducted where the incident angle and the dose profile of the beam were varied. The energy spectra from these experiments show that the angle at which the beam enters the target can influence the photopeak to Compton continuum ratios, resulting in more than 18% increase at 718 keV when the beam is parallel to the detector. Images of the 718 keV and 4.44 MeV characteristic prompt gamma ray emission from carbon-proton interactions are reconstructed using list-mode maximum likelihood expectation maximization (MLEM). Images from these prompt gamma emissions line up well with the expected location of the proton beam within the plastic targets.</i><br></p>

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