SU-E-T-605: Performance Evaluation of MLC Leaf-Sequencing Algorithms in Head-And-Neck IMRT

2015 ◽  
Vol 42 (6Part21) ◽  
pp. 3475-3475
Author(s):  
J Jing ◽  
H Lin ◽  
J Chow
Keyword(s):  
Performance Evaluation ◽  
Head And Neck ◽  
Leaf Sequencing

Quantitative Performance Evaluation of Mobile Cone-Beam CT for Head and Neck Imaging

2018 ◽  
pp. 63-67
Author(s):  
Saowapak S. Thongvigitmanee ◽  
Walita Narkbuakaew ◽  
Sorapong Aootaphao ◽  
Chalinee Thanasupsombat ◽  
Kongyot Wangkaoom ◽  
...  
Keyword(s):  
Performance Evaluation ◽  
Head And Neck ◽  
Cone Beam Ct ◽  
Cone Beam ◽  
Head And Neck Imaging ◽  
Quantitative Performance

scholarly journals EP-2166: Halcyon clinical performance evaluation for Head and Neck treatments compared to Truebeam

2018 ◽  
Vol 127 ◽  
pp. S1196-S1197
Author(s):  
D. Mihailidis ◽  
R. Scheuermann ◽  
C. Kennedy ◽  
L. Brady ◽  
L. Dong ◽  
...  
Keyword(s):  
Performance Evaluation ◽  
Head And Neck ◽  
Clinical Performance

scholarly journals Design and implementation of a prototype head and neck phantom for the performance evaluation of gamma imaging systems

2017 ◽  
Vol 4 (1) ◽  
Author(s):  
Mohammed S. Alqahtani ◽  
John E. Lees ◽  
Sarah L. Bugby ◽  
Piyal Samara-Ratna ◽  
Aik H. Ng ◽  
...  
Keyword(s):  
Performance Evaluation ◽  
Head And Neck ◽  
Imaging Systems ◽  
Gamma Imaging ◽  
Design And Implementation

scholarly journals Performance evaluation of head and neck contour adaptation with cone beam CT using two commercial software systems

2015 ◽  
Vol 54 (9) ◽  
pp. 1693-1697 ◽  
Author(s):  
Louise S. H. Bendall ◽  
Maria Najim ◽  
Rachel Stensmyr ◽  
Emily Flower ◽  
Shan Yau ◽  
...  
Keyword(s):  
Performance Evaluation ◽  
Head And Neck ◽  
Cone Beam Ct ◽  
Cone Beam ◽  
Software Systems ◽  
Commercial Software

Automatic bone and plaque removal using dual energy CT for head and neck angiography: Feasibility and initial performance evaluation

2010 ◽  
Vol 76 (1) ◽  
pp. 61-67 ◽  
Author(s):  
C. Thomas ◽  
A. Korn ◽  
B. Krauss ◽  
D. Ketelsen ◽  
I. Tsiflikas ◽  
...  
Keyword(s):  
Performance Evaluation ◽  
Head And Neck ◽  
Dual Energy ◽  
Dual Energy Ct ◽  
Plaque Removal

Copper-dependent ATP7B up-regulation drives the resistance of TMEM16A-overexpressing head-and-neck cancer models to platinum toxicity

2019 ◽  
Vol 476 (24) ◽  
pp. 3705-3719 ◽  
Author(s):  
Avani Vyas ◽  
Umamaheswar Duvvuri ◽  
Kirill Kiselyov
Keyword(s):  
Oxidative Stress ◽  
Head And Neck ◽  
Transcriptional Activation ◽  
Platinum Resistance ◽  
Mrna Levels ◽  
Strong Positive Correlation ◽  
Platinum Compounds ◽  
Copper Chelation ◽  
Novel Approach ◽  
Cancer Models

Platinum-containing drugs such as cisplatin and carboplatin are routinely used for the treatment of many solid tumors including squamous cell carcinoma of the head and neck (SCCHN). However, SCCHN resistance to platinum compounds is well documented. The resistance to platinum has been linked to the activity of divalent transporter ATP7B, which pumps platinum from the cytoplasm into lysosomes, decreasing its concentration in the cytoplasm. Several cancer models show increased expression of ATP7B; however, the reason for such an increase is not known. Here we show a strong positive correlation between mRNA levels of TMEM16A and ATP7B in human SCCHN tumors. TMEM16A overexpression and depletion in SCCHN cell lines caused parallel changes in the ATP7B mRNA levels. The ATP7B increase in TMEM16A-overexpressing cells was reversed by suppression of NADPH oxidase 2 (NOX2), by the antioxidant N-Acetyl-Cysteine (NAC) and by copper chelation using cuprizone and bathocuproine sulphonate (BCS). Pretreatment with either chelator significantly increased cisplatin's sensitivity, particularly in the context of TMEM16A overexpression. We propose that increased oxidative stress in TMEM16A-overexpressing cells liberates the chelated copper in the cytoplasm, leading to the transcriptional activation of ATP7B expression. This, in turn, decreases the efficacy of platinum compounds by promoting their vesicular sequestration. We think that such a new explanation of the mechanism of SCCHN tumors’ platinum resistance identifies novel approach to treating these tumors.

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