SU-E-T-359: Emulation of Yb-169 Gamma-Ray Spectrum Using Metal-Filtered 250 KVp X-Rays for Pre-Clinical Studies of Gold Nanoparticle-Aided Radiation Therapy

2015 ◽  
Vol 42 (6Part17) ◽  
pp. 3416-3416
Author(s):  
F Reynoso ◽  
S Cho
Keyword(s):  
Radiation Therapy ◽  
Gold Nanoparticle ◽  
Clinical Studies ◽  
Gamma Ray ◽  
X Rays

scholarly journals Assessing keloid recurrence following surgical excision and radiation

2020 ◽  
Vol 8 ◽  
Author(s):  
Michael H Gold ◽  
Mark S Nestor ◽  
Brian Berman ◽  
David Goldberg
Keyword(s):  
Radiation Therapy ◽  
Clinical Studies ◽  
Surgical Excision ◽  
External Beam Radiation ◽  
Cochrane Library ◽  
X Rays ◽  
Recurrence Rates ◽  
Beam Radiation ◽  
Reticular Dermis ◽  
Wide Range

Abstract Keloids are a fibroproliferative disorder that can result from a cutaneous injury to the reticular dermis. Recurrence rates as high as 100% have been reported following surgical excision alone. Consequently, a variety of post-surgical techniques have been employed to prevent keloid recurrence, including the use of radiation. Although numerous studies have shown post-excisional X-rays, electron beam, lasers and brachytherapy can reduce the rate of keloid recurrence, numerous inconsistencies, including a wide range of definitions for keloid recurrence, make it difficult to compare study outcomes. The review aims to examine the various means for defining keloid recurrence in clinical trials involving the use of radiation therapy. Searches of the Cochrane Library and PubMed were performed to identify the available information for post-surgical keloid recurrence following radiation therapy. Each identified study was reviewed for patient follow-up and criteria used to define keloid recurrence. The search results included clinical studies with external beam radiation, brachytherapy and superficial radiation therapy. Many studies did not include a definition of keloid recurrence, or defined recurrence only as the return of scar tissue. Other studies defined keloid recurrence based on patient self-assessment questionnaires, symptoms and scar elevation and changes in Kyoto Scar Scale, Japan Scar Workshop Scale and Vancouver Scar Scale scores. The results of this review indicate keloidectomy followed by radiation therapy provide satisfactory recurrence rates; however, clinical studies evaluating these treatments do not describe treatment outcomes or use different definitions of keloid recurrence. Consequently, recurrence rates vary widely, making comparisons across studies difficult. Keloid recurrence should be clearly defined using both objective and subjective measures.

scholarly journals Introducing the HD+B model for pulsar wind nebulae: a hybrid hydrodynamics/radiative approach

2020 ◽  
Vol 494 (3) ◽  
pp. 4357-4370
Author(s):  
B Olmi ◽  
D F Torres
Keyword(s):  
Gamma Ray ◽  
High Energy ◽  
Theoretical Modelling ◽  
X Rays ◽  
Pulsar Wind Nebulae ◽  
New Approach ◽  
Energy Gamma ◽  
Radiative Model ◽  
Pulsar Wind

ABSTRACT Identification and characterization of a rapidly increasing number of pulsar wind nebulae is, and will continue to be, a challenge of high-energy gamma-ray astrophysics. Given that such systems constitute -by far- the most numerous expected population in the TeV regime, such characterization is important not only to learn about the sources per se from an individual and population perspective, but also to be able to connect them with observations at other frequencies, especially in radio and X-rays. Also, we need to remove the emission from nebulae in highly confused regions of the sky for revealing other underlying emitters. In this paper, we present a new approach for theoretical modelling of pulsar wind nebulae: a hybrid hydrodynamic-radiative model able to reproduce morphological features and spectra of the sources, with relatively limited numerical cost.

The neutron, gamma-ray, X-ray spectrometer (NGXS): A compact instrument for making combined measurements of neutrons, gamma-rays, and X-rays

2014 ◽  
Vol 93 ◽  
pp. 524-529 ◽  
Author(s):  
David J. Lawrence ◽  
William C. Feldman ◽  
Robert E. Gold ◽  
John O. Goldsten ◽  
Ralph L. McNutt
Keyword(s):  
Gamma Rays ◽  
Gamma Ray ◽  
X Rays ◽  
X Ray ◽  
Combined Measurements

scholarly journals Particle dynamics in the stellar magnetosphere by gravitational collapse

2010 ◽  
Vol 6 (S271) ◽  
pp. 383-384
Author(s):  
Volodymyr Kryvdyk
Keyword(s):  
Thermal Radiation ◽  
Gravitational Collapse ◽  
Radiation Flux ◽  
Gamma Ray ◽  
Wide Band ◽  
Particle Dynamics ◽  
X Rays ◽  
Relativistic Jets ◽  
Stellar Radius ◽  
Polar Caps

AbstractThe particle dynamics and in the stellar magnetosphere during gravitational collapse is investigated. The formations of relativistic jets and the generation of the radiation bursts in the stellar magnetosphere by gravitational collapse are considered. As follows from results, the stars on the stage of gravitational collapse must be powerful sources of the relativistic jets and the non-thermal radiation. These jets will formed in the polar caps of collapsing stars magnetospheres, when the stellar magnetic field increases during collapse and the charged particles will be accelerate. These jets will generate the non-thermal radiation. The radiation flux grows with decreasing stellar radius and can be observed in the form of radiation burst in wide band wave- from radio to gamma-ray. These bursts radiation can be observed as gamma- and X- rays bursts.

Some Interesting Work on Capillary Glass Detectors

2014 ◽  
pp. 103-113
Keyword(s):  
Gamma Ray ◽  
X Rays ◽  
Glass Capillary ◽  
Large Area ◽  
Vacuum Technology ◽  
Gas Atmosphere ◽  
Gamma Ray Imaging ◽  
Position Sensitive ◽  
Primary Electrons ◽  
Glass Detectors

In this chapter, the progress of the development of glass capillary plates is described. In some applications, capillary plates have advantages over GEM or other gaseous detectors. For example, they are compatible with vacuum technology allowing them to be used in sealed gaseous detectors. Prototypes of capillary plates combined with photocathodes sensitive to ultraviolet and visible light were the first to be developed and successfully tested. These detectors resemble vacuum imaging microchannel plates, widely used in many applications. However, the glass capillary plates operate in gas atmosphere and in avalanche mode. This offers a possibility to build large area position-sensitive photomultipliers since at atmospheric pressure there are no serious mechanical constrains on the window. Since glass has a high density, the capillary plate can also be used as efficient convertors of X-rays, and be used at the same time as a multiplication structure for the created primary electrons. Such a device is attractive for X-ray and gamma ray imaging and the first successful tests of a prototype of such a detector are described.

scholarly journals Review of GRANAT Observations of AGNs

1994 ◽  
Vol 159 ◽  
pp. 63-72 ◽  
Author(s):  
E. Churazov ◽  
M. Gilfanov ◽  
A. Finoguenov ◽  
R. Sunyaev ◽  
M. Chernyakova ◽  
...  
Keyword(s):  
Time Scales ◽  
Gamma Ray ◽  
Broad Band ◽  
Band 3 ◽  
X Rays ◽  
X Ray ◽  
X Ray Background

Brief review of AGNs observations in the X-ray / soft gamma-ray bands with the orbital observatory GRANAT is presented.For three well known bright objects (3C273, NGC4151 and Cen A) broad band (3 keV–few hundreds keV) spectra have been obtained. Imaging capabilities allowed accurate (several arcminutes) identification of these objects with sources of hard X-rays.The spectrum of NGC4151 above ≈ 50 keV was found to be much steeper than that in most of the previous observations, while in standard X-ray band the spectrum agrees with observed previously. The comparison of the observed spectra with that of the X-Ray Background (XRB) indicates that sources similar to NGC4151 could reproduce the shape of XRB spectrum in 3–60 keV band.Cen A was observed in the very low state during most of observations in 1990–1993, except for two observations in 1991. The variability of the hard X-ray flux has been detected on the time scales of several days.

Study on the Size Dependence of AuNPs in Enhancement Radiation Effect for Superficial Kilovoltage X-Rays

2019 ◽  
Vol 290 ◽  
pp. 81-86
Author(s):  
Nur Shafawati binti Rosli ◽  
Azhar Abdul Rahman ◽  
Azlan Abdul Aziz ◽  
Shaharum Shamsuddin ◽  
Suhana Arshad
Keyword(s):  
Radiation Therapy ◽  
Free Radicals ◽  
Radiation Effects ◽  
Radiation Effect ◽  
Photoelectric Effect ◽  
Enhancement Effect ◽  
X Rays ◽  
Dose Enhancement ◽  
X Ray ◽  
Mcf 7

Radiation therapy and chemotherapy remain the most widely used treatment options in treating cancer. Recent developments in cancer research show that therapy combined with high-atomic number materials such as gold nanoparticles (AuNPs) is a new way to treat cancer, in which AuNPs are injected through intravenous administration and bound to tumor sites has enhanced tumor cell killing. Radiation therapy aims to deliver a high therapeutic dose of ionizing radiation to the tumor without exceeding normal tissue tolerance. In this work AuNPs have been used for the enhancement of radiation effects on breast cancer cells (MCF-7) for superficial kilovoltage X-ray radiation therapy. The use of AuNPs in superficial kilovoltage X-ray beams radiation therapy will provide a high probability for photon interaction by photoelectric effect. These provide advantages in terms of radiation dose enhancement. In this work, MCF-7 cells were seeded in the 96-well plate and treated with 13 nm, 50 nm and 70 nm AuNPs before they were irradiated with 80 kVp X-rays beam at various radiation doses. Photoelectric effect is the dominant process of interaction of 80 kVp X-rays with AuNPs. When the AuNPs are internalized into the MCF-7 cells, the dose enhancement effect is observed. The presence of AuNPs in the MCF-7 cells will produce a higher number of photoelectrons, and resulting more “free radicals” that will lead to increase in cell death. Then, these free radicals will lead to DNA damage to the MCF-7 cells. To validate the enhanced killing effect, both with and without AuNPs MCF-7 cells is irradiated simultaneously. By comparison, the results show that AuNPs significantly enhance cancer killing and the enhancement radiation effect was dependent on the size of AuNPs.

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