SU-E-J-241: Wavelet-Based Temporal Feature Extraction From DCE-MRI to Identify Sub-Volumes of Low Blood Volume in Head-And-Neck Cancer

2015 ◽  
Vol 42 (6Part11) ◽  
pp. 3321-3321 ◽  
Author(s):  
D You ◽  
M Aryal ◽  
S Samuels ◽  
A Eisbruch ◽  
Y Cao
Keyword(s):  
Feature Extraction ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Blood Volume ◽  
Neck Cancer ◽  
Dce Mri ◽  
Temporal Feature

SU-D-BRB-06: Comprehensive Population-Averaged Arterial Input Function (AIF) for DCE-MRI of Head and Neck Cancer

2012 ◽  
Vol 39 (6Part3) ◽  
pp. 3615-3616 ◽  
Author(s):  
J Onxley ◽  
D Yoo ◽  
N Muradyan ◽  
J MacFall ◽  
D Brizel ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Arterial Input Function ◽  
Input Function ◽  
Dce Mri

scholarly journals Comparison of DCE-MRI kinetic parameters and FMISO-PET uptake parameters in head and neck cancer patients

2017 ◽  
Vol 44 (6) ◽  
pp. 2358-2368 ◽  
Author(s):  
Urban Simoncic ◽  
Sara Leibfarth ◽  
Stefan Welz ◽  
Nina Schwenzer ◽  
Holger Schmidt ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Kinetic Parameters ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Dce Mri

scholarly journals Prospective assessment of DCE-MRI parameters associated with advanced mandibular osteoradionecrosis after IMRT for head and neck cancer

2019 ◽  
Author(s):  
◽  
Abdallah S. R. Mohamed ◽  
Renjie He ◽  
Yao Ding ◽  
Jihong Wang ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Radiation Treatment ◽  
External Beam Radiotherapy ◽  
Mirror Image ◽  
Self Control ◽  
Anatomical Location ◽  
Curative Intent ◽  
Dce Mri

AbstractPurposeWe aim to characterize the quantitative DCE-MRI parameters associated with advanced mandibular osteoradionecrosis (ORN) compared to the contralateral normal mandible.Experimental DesignPatients with the diagnosis of advanced ORN after curative-intent radiation treatment of head and neck cancer were prospectively enrolled after institutional-review board approval and study-specific informed consent. Eligibility criteria included; age>18 years, pathological evidence of head and neck malignancy with history of curative-intent external beam radiotherapy; patients with clinically confirmed high-grade ORN requiring surgical intervention; and no contraindications to MRI. The DCE-MRI acquisition consisted of a variable flip angle T1 mapping sequence and a multi-phase 3D FSPGR sequence. Quantitative maps generated with the Tofts and extended Tofts pharmacokinetic model were used for analysis. Motion correction was applied. Manual segmentation of advanced ORN 3-D volume was done using anatomical sequences (T1, T2, and T1+contrast) to create ORN volumes of interest (ORN-VOIs).Subsequently, normal mandibular VOIs were segmented on the contralateral healthy mandible of similar volume and anatomical location (i.e., mirror image) to create self-control VOIs. Finally, anatomical sequences were co-registered to DCE sequences, and contours were propagated to the respective quantitative parameter maps.ResultsThirty patients were included. Median age at diagnosis was 58 years (range 19-78), and 83% were men. The site of tumor origin was in the oropharynx, oral cavity, salivary glands, and nasopharynx in 13, 9, 6, and 2 patients, respectively. The median time to ORN development after completion of IMRT was 38 months (range 6-184). There were statistically significant higher Ktrans and Ve values in ORN-VOIs compared with controls (0.23 vs. 0.07 min−1, and 0.34 vs. 0.15, p <0.0001 for both) using matched pairs analysis. The average relative increase of Ktrans in ORN-VOIs was 3.2 folds healthy mandibular control VOIs. Moreover, the corresponding rise of Ve in ORN-VOIs was 2.7 folds higher than the controls. Using combined Ktrans and Ve parameters, 27 patients (90%) had at least a 200% increase of either of the studied parameters in the ORN-VOIs compared with their healthy mandible control VOIs.ConclusionOur results confirm there is a quantitatively significant higher degree of leakiness in the mandibular vasculature as measured using DCE-MRI parameters of areas affected with an advanced grade of ORN versus healthy mandible. We were able to measure significant increases in quantitative metrics compared to values from the non-ORN mandibular bone. Further efforts are ongoing to validate these findings to enable the use of these DCE-MRI parameter thresholds for the early detection of subclinical cases of ORN.

scholarly journals PV-0474: Comparison of DCE MRI and FMISO-PET kinetic parameters in head and neck cancer patients

2016 ◽  
Vol 119 ◽  
pp. S225-S226
Author(s):  
U. Simoncic ◽  
S. Leibfarth ◽  
S. Welz ◽  
N. Schwenzer ◽  
H. Schmidt ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Kinetic Parameters ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Dce Mri
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