scholarly journals Development and evaluation of convergent and accelerated penalized SPECT image reconstruction methods for improved dose-volume histogram estimation in radiopharmaceutical therapy

2014 ◽  
Vol 41 (11) ◽  
pp. 112507 ◽  
Author(s):  
Lishui Cheng ◽  
Robert F. Hobbs ◽  
George Sgouros ◽  
Eric C. Frey
Keyword(s):  
Image Reconstruction ◽  
Dose Volume Histogram ◽  
Spect Image ◽  
Reconstruction Methods ◽  
Dose Volume ◽  
Histogram Estimation ◽  
Radiopharmaceutical Therapy

scholarly journals SEMIQUANTITATIVE EVALUATION OF 99MTCTRODAT1 BINDING POTENTIAL BY TWO METHODS OF SPECT IMAGE RECONSTRUCTION.

2019 ◽  
Vol 7 (2A) ◽  
Author(s):  
Melissa Furlaneto Lellis Leite ◽  
Marilia Alves dos Reis ◽  
Cássio Miri Oliveira ◽  
Mario Luiz Vieira Castiglioni ◽  
Rodrigo Affonseca Bressan
Keyword(s):  
Image Reconstruction ◽  
Effect Size ◽  
Neurological Disorders ◽  
Visual Inspection ◽  
Binding Potential ◽  
Back Projection ◽  
Large Effect Size ◽  
Spect Image ◽  
Reconstruction Methods ◽  
Semiquantitative Evaluation

TRODAT-1 is a radiopharmaceutical derived from tropane and linked to tecnecium-99m ([99mTc] TRODAT-1) has been used in studies of dopamine transporter (DAT) in central nervous system. Associated with the SPECT technique of acquisition, is able to detect changes in neurological disorders like Parkinson´s disease, evaluating the binding potential (BP) of DAT. The aim of this study was to evaluate the influence of the image reconstruction methods, Filtered Back Projection (FBP) and iterative reconstruction (OSEM), in BP values at the striatal region in 30 healthy volunteers. Images were analyzed by visual inspection and semi-quantitative analysis. Regions of interest (ROI) were made over striatal areas on both sides. Nonparametric Wilcoxon statistical analysis was performed between the BP values from the FBP and OSEM methods. Our results showed that the reconstruction methods have a statistical significant BP values difference in the total striatum (Z = -2,2787 p = 0.005), right striatum (Z = -2,602 p = 0.009) and left striatum (Z= 2,746 p = 0.006). The effect size was calculated to see if there influence in this test: the "large effect size" for all measurements was observed (total striatum r= -0.51; right striatum r= -0.48; left striatum r= -0.50). FBP is the usual method of reconstruction for brain SPECT images, and our results showed influence of the OSEM method in BP. It is concluded that the method of image reconstruction adopted should be standardized to avoid incorrect evaluations of BP values using [99mTc]TRODAT-1.

scholarly journals Dose volume histogram-based optimization of image reconstruction parameters for quantitative90Y-PET imaging

2018 ◽  
Vol 46 (1) ◽  
pp. 229-237 ◽  
Author(s):  
Wendy Siman ◽  
Justin K. Mikell ◽  
Osama R. Mawlawi ◽  
Firas Mourtada ◽  
S. Cheenu Kappadath
Keyword(s):  
Image Reconstruction ◽  
Pet Imaging ◽  
Dose Volume Histogram ◽  
Dose Volume

Differences of Ring Applicator Reconstruction Methods in Brachytherapy

2021 ◽  
Vol 91 (3) ◽  
pp. 46-54
Author(s):  
D. I. Kazlouski ◽  
A. U. Plysheuskaya
Keyword(s):  
Radiation Source ◽  
Ct Images ◽  
Patient Treatment ◽  
Quality Assurance Program ◽  
Reconstruction Method ◽  
Dose Volume Histogram ◽  
Dose Delivery ◽  
Tracking Method ◽  
Reconstruction Methods ◽  
Dose Volume

Purpose: Analysis and comparison of existing reconstruction methods of the ring applicator, as well as the development of reconstruction method that is closest to the actual source path in dosimetric planning using brachytherapy. Material and methods: Evaluation of reconstruction methods was carried out on the basis of CT images, which were used for dosimetric planning of patient treatment. The obtained data on the positioning of the radiation source using X-ray images were transferred to CT images using matrix transformation methods. A method of reconstruction along the source path is proposed, in which the minimum discrepancies in the location of the source positions in comparison with the coordinates of the actual source positions were obtained. For comparison, the reconstruction of the applicator was performed by three different methods: the method using the manufacturer’s applicator libraries, along the source path, and the method proposed above. Results: The results were assessed using a dose-volume histogram. Dose characteristics were selected based on the recommended ICRU Report 89. To assess the presence of the effect of the reconstruction method on the dose characteristics, the Friedman criterion was used. The differences between the doses for different reconstruction methods turned out to be significant (the critical value of the significance level was considered p=0.05). The maximum deviations of the median values of the parameters of the dose-volume histogram were 7.8 % for the “lib” method, 8.6 % for the tracking method, and 7.9 % for the track_new method. We calculated the median values of the deviations of the source positions obtained using the previously described reconstruction methods from the actual stopping positions of the source found experimentally. Conclusion: The use of the proposed reconstruction method track_new increases the accuracy of determining the positions of the stop of the radiation source in the applicator and, as a consequence, the accuracy of dose delivery on the brachytherapy apparatus in comparison with the manual tracking method. The methods used in this study can be used when putting the applicators into clinical use as part of a radiotherapy quality assurance program. The obtained results will be useful to medical physicists if it is necessary to choose a technique for carrying out the reconstruction of the applicator in accordance with the available capabilities and imaging methods and, as a result, will increase the accuracy of dosimetric planning and dose delivery on brachytherapy afterloaders.

Region of interest evaluation of SPECT image reconstruction methods using a realistic brain phantom

1997 ◽  
Vol 44 (3) ◽  
pp. 1336-1341 ◽  
Author(s):  
W. Xia ◽  
S.J. Glick ◽  
Tin-Su Pan ◽  
E.J. Soares ◽  
Der-Shan Luo
Keyword(s):  
Image Reconstruction ◽  
Region Of Interest ◽  
Spect Image ◽  
Reconstruction Methods ◽  
Brain Phantom
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