TH-E-BRF-01: Exploiting Tumor Shrinkage in Split-Course Radiotherapy

2014 ◽  
Vol 41 (6Part33) ◽  
pp. 569-569
Author(s):  
J Unkelbach ◽  
D Craft ◽  
T Hong ◽  
D Papp ◽  
J Ramakrishnan ◽  
...  
Keyword(s):  
Tumor Shrinkage ◽  
Split Course Radiotherapy

scholarly journals GCT-69. VOLUMETRIC CHANGE BEFORE CHEMORADIOTHERAPY AND INFLUENCE OF DIAGNOSTIC RADIATION EXPOSURE IN INTRACRANIAL GERMINOMAS

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii342-iii342
Author(s):  
Naoki Kagawa ◽  
Ryuichi Hirayama ◽  
Chisato Yokota ◽  
Yasuyoshi Chiba ◽  
Yasunori Fujimoto ◽  
...  
Keyword(s):  
Radiation Dose ◽  
Germ Cell ◽  
Tumor Volume ◽  
Disease Onset ◽  
Germ Cell Tumors ◽  
Tumor Shrinkage ◽  
Volumetric Change ◽  
Volumetric Assessment ◽  
Intracranial Germ Cell Tumors ◽  
Diagnostic Radiation

Abstract BACKGROUND Spontaneous regression in intracranial germ cell tumors has been reported in some literatures, but the mechanism has not been well known. We retrospectively measured the tumor volume before chemoradiotherapy and analyzed factors that influence reduction of tumor volume. PATIENTS AND METHODS Plural MRI scans were done before the first course of chemotherapy regimen in 27 patients with primary intracranial germinomas. Their age ranged from 8 to 31 years. 35 lesions from them were enrolled and included 13 pineal, 4 neurohypophyseal, 4 basal ganglia, 4 bifocal type, and 2 multiple lesions. All regions were verified as pure germinoma or HCG-producing germinoma by histopathological examination. Tumor volume of 35 lesions was analyzed by volumetric assessment based on MRI. Ratio of volumetric change between the first MRI and the scan immediately before chemotherapy was defined as shrinking rate (%). Period between disease onset and the first chemotherapy was 20 to 47 days. Diagnostic radiation dose was calculated in each case. RESULTS Initial tumor volume ranged from 0.962 to 72.356 cubic centimeters (mean: 8.27). Diagnostic radiation dose: 40.5 to 910.1 mGy. Shrinking rate ranged from -57.8 to 85.4% (mean: 30.8). In 10 regions, shrinking rate was within 30%. Shrinking rate was significant positively influenced by diagnostic radiation dose (p<0.05) and negatively influenced by initial volume (p<0.05). But, other factors such as age, sex, histopathological parameters did not influence tumor shrinkage. CONCLUSION This study shows that the volume of intracranial germ cell tumors is changing dynamically before chemoradiotherapy in many cases. Diagnostic exposure to low-dose radiation influences tumor shrinkage of intracranial germinomas.

scholarly journals Exploiting tumor shrinkage through temporal optimization of radiotherapy

2014 ◽  
Vol 59 (12) ◽  
pp. 3059-3079 ◽  
Author(s):  
Jan Unkelbach ◽  
David Craft ◽  
Theodore Hong ◽  
Dávid Papp ◽  
Jagdish Ramakrishnan ◽  
...  
Keyword(s):  
Tumor Shrinkage

Clinical Experience With Split-Course Radiotherapy

Radiology ◽  
1969 ◽  
Vol 92 (3) ◽  
pp. 591-596 ◽  
Author(s):  
Lars R. Holsti
Keyword(s):  
Clinical Experience ◽  
Split Course Radiotherapy

scholarly journals SUN-463 Tumor Shrinkage with Preoperative Relacorilant Therapy in Two Patients with Cushing Disease Due to Pituitary Macroadenomas

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Massimo Terzolo ◽  
Davide Iacuaniello ◽  
Anna Pia ◽  
Priola Adriano ◽  
Andreas Moraitis ◽  
...  
Keyword(s):  
Tumor Shrinkage ◽  
Cushing Disease ◽  
Pituitary Macroadenomas
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