WE-D-9A-05: Medical Hyperspectral Imaging for the Detection of Head and Neck Cancer in Animal Models

2014 ◽  
Vol 41 (6Part29) ◽  
pp. 500-501 ◽  
Author(s):  
B Fei ◽  
G Lu ◽  
R Pike ◽  
D Wang ◽  
G Chen
Keyword(s):  
Head And Neck Cancer ◽  
Animal Models ◽  
Head And Neck ◽  
Hyperspectral Imaging ◽  
Neck Cancer

scholarly journals Role of near-infrared fluorescence imaging in head and neck cancer surgery: from animal models to humans

2014 ◽  
Vol 272 (10) ◽  
pp. 2593-2600 ◽  
Author(s):  
Ihab Atallah ◽  
Clément Milet ◽  
Jean-Luc Coll ◽  
Emile Reyt ◽  
Christian Adrien Righini ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Animal Models ◽  
Head And Neck ◽  
Fluorescence Imaging ◽  
Neck Cancer ◽  
Near Infrared ◽  
Cancer Surgery ◽  
Near Infrared Fluorescence ◽  
Near Infrared Fluorescence Imaging

Alloantigen gene therapy for head and neck cancer: Evaluation of animal models

Head & Neck ◽  
2003 ◽  
Vol 25 (4) ◽  
pp. 274-279 ◽  
Author(s):  
Lyon L. Gleich ◽  
Ya-Qin Li ◽  
Shunan Li ◽  
Jack L. Gluckman ◽  
Peter J. Stambrook
Keyword(s):  
Gene Therapy ◽  
Head And Neck Cancer ◽  
Animal Models ◽  
Head And Neck ◽  
Neck Cancer

scholarly journals Detection of Head and Neck Cancer in Surgical Specimens Using Quantitative Hyperspectral Imaging

2017 ◽  
Vol 23 (18) ◽  
pp. 5426-5436 ◽  
Author(s):  
Guolan Lu ◽  
James V. Little ◽  
Xu Wang ◽  
Hongzheng Zhang ◽  
Mihir R. Patel ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Hyperspectral Imaging ◽  
Neck Cancer

VISUALIZATION OF HEAD AND NECK CANCER MODELS WITH A TRIPLE FUSION REPORTER GENE

2012 ◽  
Vol 05 (04) ◽  
pp. 1250028 ◽  
Author(s):  
YING ZHENG ◽  
QIAOYA LIN ◽  
HONGLIN JIN ◽  
JUAN CHEN ◽  
ZHIHONG ZHANG
Keyword(s):  
Head And Neck Cancer ◽  
Animal Models ◽  
Tumor Growth ◽  
Head And Neck ◽  
Reporter Gene ◽  
Neck Cancer ◽  
Bioluminescence Imaging ◽  
Head And Neck Tumors ◽  
Neck Tumors

The development of experimental animal models for head and neck tumors generally rely on the bioluminescence imaging to achieve the dynamic monitoring of the tumor growth and metastasis due to the complicated anatomical structures. Since the bioluminescence imaging is largely affected by the intracellular luciferase expression level and external D-luciferin concentrations, its imaging accuracy requires further confirmation. Here, a new triple fusion reporter gene, which consists of a herpes simplex virus type 1 thymidine kinase (TK) gene for radioactive imaging, a far-red fluorescent protein (mLumin) gene for fluorescent imaging, and a firefly luciferase gene for bioluminescence imaging, was introduced for in vivo observation of the head and neck tumors through multi-modality imaging. Results show that fluorescence and bioluminescence signals from mLumin and luciferase, respectively, were clearly observed in tumor cells, and TK could activate suicide pathway of the cells in the presence of nucleotide analog-ganciclovir (GCV), demonstrating the effectiveness of individual functions of each gene. Moreover, subcutaneous and metastasis animal models for head and neck tumors using the fusion reporter gene-expressing cell lines were established, allowing multi-modality imaging in vivo. Together, the established tumor models of head and neck cancer based on the newly developed triple fusion reporter gene are ideal for monitoring tumor growth, assessing the drug therapeutic efficacy and verifying the effectiveness of new treatments.

scholarly journals Superpixel-based spectral classification for the detection of head and neck cancer with hyperspectral imaging

2016 ◽  
Author(s):  
Hyunkoo Chung ◽  
Guolan Lu ◽  
Zhiqiang Tian ◽  
Dongsheng Wang ◽  
Zhuo Georgia Chen ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Hyperspectral Imaging ◽  
Neck Cancer ◽  
Spectral Classification
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