TU-F-12A-07: Cardiac Fiber Imaging Using High-Frequency Ultrasound in Animal Models

2014 ◽  
Vol 41 (6Part28) ◽  
pp. 482-482
Author(s):  
B Fei ◽  
X Qin ◽  
S Wang ◽  
M Shen ◽  
M Wagner ◽  
...  
2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Wei Chen ◽  
Jiun-Yu Chen ◽  
Yu-Tang Tung ◽  
Hsiao-Ling Chen ◽  
Chia-Wen Kuo ◽  
...  

The animals used in liver fibrosis studies must usually be sacrificed. Ultrasound has been demonstrated to have the ability to diagnose hepatic fibrosis and cirrhosis in experimental small-animal models. However, few studies have used high-frequency ultrasound (HFU, 40 MHz) to monitor changes in the rat liver and other hollow organs longitudinally. In this study, liver fibrosis was induced by administering dimethylnitrosamine (DMN) in SD rats, aged 8 weeks, for three consecutive days per week for up to 4 weeks. A Chinese herbal medicine Yi Guan Jian (YGJ) was orally administered (1.8 g/kg daily) to DMN-induced liver fibrosis rats for 2 weeks. Compared with the normal control rats, rats treated with DMN for either 2 weeks or 4 weeks had significantly lower body weights, liver indexes and elevation of hydroxyproline, GOT, and GPT contents. YGJ herbal treatment remarkably prevented rats from DMN-induced liver fibrosis. The HFU scoring results among the normal controls, 2-week DMN-treated rats, 4-week DMN-treated rats, and combined 2-week YGJ therapy with 4-week DMN-treated rats also reached statistical significance. Thus, HFU is an accurate tool for the longitudinal analysis of liver fibrosis progression in small-animal models, and the YGJ may be useful in reversing the development of hepatic fibrosis.


Medicine ◽  
2019 ◽  
Vol 98 (37) ◽  
pp. e17111 ◽  
Author(s):  
Xiang-qin Gao ◽  
Xiao-mei Xue ◽  
Jian-kang Zhang ◽  
Fei Yan ◽  
Qiu-xia Mu

Author(s):  
Carolina Ávila de Almeida ◽  
Simone Guarçoni ◽  
Bruna Duque Estrada ◽  
Maria Carolina Zafra Páez ◽  
Clarissa Canella

2020 ◽  
Vol 10 (1) ◽  
pp. 17
Author(s):  
Iris Wohlmuth-Wieser ◽  
Joel M. Ramjist ◽  
Neil Shear ◽  
Raed Alhusayen

The diagnosis of cutaneous T-cell lymphomas (CTCL) is frequently delayed by a median of three years and requires the clinical evaluation of an experienced dermatologist and a confirmatory skin biopsy. Dermoscopy and high-frequency ultrasound (HFUS) represent two non-invasive diagnostic tools. While dermoscopy is inexpensive and widely used for the diagnosis of melanoma and non-melanoma skin cancers, HFUS of skin lymphomas represents a novel diagnostic approach that is not yet implemented in the routine dermatologic practice. The aim of our study was to prospectively assess skin lesions of patients with either CTCL patches or plaques with dermoscopy and HFUS and to compare the findings with atopic dermatitis (AD) and psoriasis. Thirteen patients with an established diagnosis of CTCL, psoriasis, or AD were studied: Dermoscopy features including spermatozoa-like structures and the presence of white scales could assist in differentiating between early-stage CTCL and AD. HFUS measurements of the skin thickness indicated increased epidermal-, thickness in CTCL, and psoriasis compared with AD. Our results support the use of dermoscopy as a useful tool to diagnose CTCL. HFUS could augment the dermatologic assessment, but further studies will be needed to define standardized parameters.


Author(s):  
Shakthi Pragasam ◽  
Rashmi Kumari ◽  
Malathi Munisamy ◽  
Devinder Mohan Thappa

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