TU-F-12A-01: Quantitative Non-Linear Compartment Modeling of 89Zr- and 124I- Labeled J591 Monoclonal Antibody Kinetics Using Serial Non-Invasive Positron Emission Tomography Imaging in a Pre-Clinical Human Prostate Cancer Mouse Model

2014 ◽  
Vol 41 (6Part28) ◽  
pp. 480-480
Author(s):  
EK Fung ◽  
SM Cheal ◽  
S Chalasani ◽  
SB Fareedy ◽  
B Otto ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Positron Emission Tomography ◽  
Positron Emission Tomography Imaging ◽  
Emission Tomography ◽  
Human Prostate Cancer ◽  
Tomography Imaging ◽  
Non Invasive ◽  
Compartment Modeling ◽  
Positron Emission ◽  
Antibody Kinetics

Positron emission tomography imaging of vascular endothelial growth factor with 64Cu-labeled bevacizumab for non-invasive diagnosis of endometriosis

2019 ◽  
Vol 11 (4) ◽  
pp. 194-200
Author(s):  
Tumenjargal Amartuvshin ◽  
Hirofumi Hanaoka ◽  
Aiko Yamaguchi ◽  
Yoshito Tsushima
Keyword(s):  
Positron Emission Tomography ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Positron Emission Tomography Imaging ◽  
Emission Tomography ◽  
Vascular Endothelial ◽  
Tomography Imaging ◽  
Non Invasive ◽  
Positron Emission ◽  
Endothelial Growth Factor

Introduction: Non-invasive diagnosis of endometriosis remains challenging. A promising approach for diagnosing endometriosis is the molecular imaging of vascular endothelial growth factor because angiogenesis plays a role in the establishment of endometriosis. This study aimed to evaluate the potential of copper-64-labeled bevacizumab, an anti–vascular endothelial growth factor antibody, for endometriosis imaging. Methods: Mouse endometriosis model was prepared by autologous transplantation. The vascular endothelial growth factor expression was evaluated by immunohistochemical staining. Biodistribution study and positron emission tomography imaging were performed at 1, 24, and 48 h after the injection of radiolabeled bevacizumab. Results: The immunohistochemical staining revealed that vascular endothelial growth factor is expressed around the stroma and glandular epithelial cells in the endometriosis lesion. The biodistribution study showed a high uptake of indium-111 bevacizumab in the endometriosis lesion. Positron emission tomography imaging with copper-64-labeled bevacizumab clearly visualized the endometriosis lesions at 24 and 48 h after injection. Conclusion: These results indicate the potential usefulness of copper-64-labeled bevacizumab for endometriosis imaging.

scholarly journals Positron emission tomography imaging of prostate cancer

Amino Acids ◽  
2009 ◽  
Vol 39 (1) ◽  
pp. 11-27 ◽  
Author(s):  
Hao Hong ◽  
Yin Zhang ◽  
Jiangtao Sun ◽  
Weibo Cai
Keyword(s):  
Prostate Cancer ◽  
Positron Emission Tomography ◽  
Positron Emission Tomography Imaging ◽  
Emission Tomography ◽  
Tomography Imaging ◽  
Positron Emission
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