SU-E-CAMPUS-J-06: The Impact of CT-Scan Energy On Range Uncertainty in Proton Therapy Planning

2014 ◽  
Vol 41 (6Part22) ◽  
pp. 387-387 ◽  
Author(s):  
K Grantham ◽  
H Li ◽  
T Zhao ◽  
E Klein
2015 ◽  
Vol 16 (6) ◽  
pp. 100-109
Author(s):  
Kevin K. Grantham ◽  
Hua Li ◽  
Tianyu Zhao ◽  
Eric E. Klein

2021 ◽  
Author(s):  
Esther Bär ◽  
Charles‐Antoine Collins‐Fekete ◽  
Vasilis Rompokos ◽  
Ying Zhang ◽  
Mark N. Gaze ◽  
...  

2016 ◽  

Aim: To study the impact of tumour regression occurring during IMRT for locally advanced carcinoma cervix and study dose distribution to target volume and OARs and hence the need for any replanning. Materials and Methods: 40 patients undergoing IM-IGRT and weekly chemotherapy were included in the study. After 36 Gy, a second planning CT-scan was done and target volume and OARs were recontoured. First plan (non-adaptive) was compared with second plan (adaptive plan) to evaluate whether it would still offer sufficient target coverage to the CTV and spare the OARs after having delivered 36 Gy. Finally new plan was created based on CT-images to investigate whether creating a new treatment plan would optimize target coverage and critical organ sparing. To measure the response of the primary tumour and pathologic nodes to EBRT, the differences in the volumes of the primary GTV and nodal GTV between the pretreatment and intratreatment CT images was calculated. Second intratreatment IMRT plans was generated, using the delineations of the intratreatment CT images. The first IMRT plan (based on the first CT-scan or non adaptive plan) was compared with second IMRT plan (based on the second CT-scan or adaptive plan). Results: 35% patients had regression in GTV in the range of 4.1% to 5%, 20% in the range of 1.1%-2%, 15% in the range of 2.1%-3% and 20% in the range of 6%-15%. There was significant mean decrease in GTV of 4.63 cc (p=0.000). There was a significant decrease in CTV on repeat CT done after 36 Gy by 23.31 cc (p=0.000) and in PTV by 23.31 cc (p=0.000). There was a statistically significant increase in CTV D98, CTV D95, CTV D50 and CTV D2 in repeat planning CT done after 36 Gy. There was no significant alteration in OARs doses. Conclusion: Despite tumour regression and increased target coverage in locally advanced carcinoma cervix after a delivery of 36 Gy there was no sparing of OARs. Primary advantage of adaptive RT seems to be in greater target coverage with non-significant normal tissue sparing.


2018 ◽  
Vol 8 (3) ◽  
pp. e87-e97 ◽  
Author(s):  
Kylie Dundas ◽  
Elise M. Pogson ◽  
Vikneswary Batumalai ◽  
Geoff P. Delaney ◽  
Miriam M. Boxer ◽  
...  

2020 ◽  
Vol 13 (3) ◽  
pp. 230-237
Author(s):  
Yoshiro Ieko ◽  
Noriyuki Kadoya ◽  
Takayuki Kanai ◽  
Yujiro Nakajima ◽  
Kazuhiro Arai ◽  
...  

10.26879/942 ◽  
2020 ◽  
Author(s):  
Rosie Oakes ◽  
Morgan Hill Chase ◽  
Mark Siddall ◽  
Jocelyn Sessa
Keyword(s):  
Ct Scan ◽  

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Olivier Taton ◽  
Emmanuelle Papleux ◽  
Benjamin Bondue ◽  
Christiane Knoop ◽  
Sébastien Van Laethem ◽  
...  

Background. Bronchoalveolar lavage (BAL) is currently not recommended in noncritically ill patients for the diagnosis of SARS-CoV-2 infection. Indeed, the diagnosis is based on the RT-PCR test on a nasopharyngeal swab (NPS) and abnormal findings on the chest CT scan. However, the sensitivity of the NPS and the specificity of the chest CT scan are low. Results of BAL in case of negative NPS testing are underreported, especially in the subgroup of immunocompromised patients. Objectives. The added value of BAL in the management of unstable, but noncritically ill patients, suspected of having SARS-CoV-2 infection despite one previous negative NPS and the side effects of the procedure for the patients and the health-care providers, were assessed during the epidemic peak of the COVID-19 outbreak in Belgium. Methods. This multicentric study included all consecutive noncritically ill patients hospitalized with a clinical and radiological suspicion of SARS-CoV-2 infection but with a negative NPS. BAL was performed according to a predefined decisional algorithm based on their state of immunocompetence, the chest CT scan features, and their respiratory status. Results. Among the 55 patients included in the study, 14 patients were diagnosed with a SARS-CoV-2 infection. Interestingly, there was a relationship between the cycle threshold of the RT-PCR and the interval of time between the symptom onset and the BAL procedure ( Pearso n ’ s   correlation   coefficient = 0.8 , p = 0.0004 ). Therapeutic management was changed in 33 patients because another infectious agent was identified in 23 patients or because an alternative diagnosis was made in 10 patients. In immunocompromised patients, the impact of BAL was even more marked (change in therapy for 13/17 patients). No significant adverse event was noted for patients or health-care staff. All health-care workers remained negative for SARS-CoV-2 NPS and serology at the end of the study. Conclusions. In this real-life study, BAL can be performed safely in selected noncritically ill patients suspected of SARS-CoV-2 infection, providing significant clinical benefits that outweigh the risks.


1998 ◽  
Author(s):  
Sebastian Noeh ◽  
Klaus Haarbeck ◽  
Norbert Bornfeld ◽  
Thomas Tolxdorff

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