SU-E-T-493: Analysis of the Impact of Range and Setup Uncertainties On the Dose to Brain Stem and Whole Brain in the Passively Scattered Proton Therapy Plans

2014 ◽  
Vol 41 (6Part19) ◽  
pp. 340-340
Author(s):  
N Sahoo ◽  
X Zhu ◽  
X Zhang ◽  
F Poenisch ◽  
H Li ◽  
...  
Keyword(s):  
Brain Stem ◽  
Proton Therapy ◽  
Whole Brain ◽  
Scattered Proton ◽  
The Impact

scholarly journals Assessment of the impact of CT calibration procedures for proton therapy planning on paediatric treatments

2021 ◽  
Author(s):  
Esther Bär ◽  
Charles‐Antoine Collins‐Fekete ◽  
Vasilis Rompokos ◽  
Ying Zhang ◽  
Mark N. Gaze ◽  
...  
Keyword(s):  
Proton Therapy ◽  
Therapy Planning ◽  
The Impact

The impact of 4DCT-ventilation imaging-guided proton therapy on stereotactic body radiotherapy for lung cancer

2020 ◽  
Vol 13 (3) ◽  
pp. 230-237
Author(s):  
Yoshiro Ieko ◽  
Noriyuki Kadoya ◽  
Takayuki Kanai ◽  
Yujiro Nakajima ◽  
Kazuhiro Arai ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Proton Therapy ◽  
Stereotactic Body Radiotherapy ◽  
Ventilation Imaging ◽  
The Impact

scholarly journals Dosimetric Comparison of Helical Tomotherapy and Intensity-Modulated Proton Therapy in Hippocampus- and Scalp-Sparing Whole Brain Radiotherapy

2021 ◽  
Vol 20 ◽  
pp. 153303382110601
Author(s):  
Taiki Takaoka ◽  
Natsuo Tomita ◽  
Tomoki Mizuno ◽  
Shingo Hashimoto ◽  
Takahiro Tsuchiya ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Proton Therapy ◽  
Helical Tomotherapy ◽  
Whole Brain Radiotherapy ◽  
Conformity Index ◽  
Target Dose ◽  
Whole Brain ◽  
Intensity Modulated Proton Therapy ◽  
Intensity Modulated ◽  
Brain Radiotherapy

Objective: Cognitive decline and alopecia after radiotherapy are challenging problems. We aimed to compare whole brain radiotherapy (WBRT) plans reducing radiation dose to the hippocampus and scalp between helical tomotherapy (HT) and intensity-modulated proton therapy (IMPT). Methods: We conducted a planning study of WBRT for 10 patients. The clinical target volume was defined as the whole brain excluding the hippocampus avoidance (HA) region. The prescribed dose was 30 Gy in 10 fractions to cover 95% of the target. Constraint goals were defined for the target and organs at risk (OAR). Results: Both techniques met the dose constraints for the target and OAR. However, the coverage of the target (dose covering 95% [D95%] and 98% [D98%] of the volume) were better in IMPT than HT (HT vs IMPT: D95%, 29.9 Gy vs 30.0 Gy, P < .001; D98%, 26.7 Gy vs 28.1 Gy, P = .002). The homogeneity and conformity of the target were also better in IMPT than HT (HT vs IMPT: homogeneity index, 1.50 vs 1.28, P < .001; conformity index, 1.30 vs 1.14, P < .001). IMPT reduced the D100% of the hippocampus by 59% (HT vs IMPT: 9.3 Gy vs 3.8 Gy, P < .001) and reduced the Dmean of the hippocampus by 37% (HT vs IMPT: 11.1 Gy vs 7.0 Gy, P < .001) compared with HT. The scalp IMPT reduced the percentage of the volume receiving at least 20 Gy (V20Gy) and V10Gy compared with HT (HT vs IMPT: V20Gy, 56.7% vs 6.6%, P < .001; V10Gy, 90.5% vs 37.1%, P < .001). Conclusion: Both techniques provided acceptable target dose coverage. Especially, IMPT achieved excellent hippocampus- and scalp-sparing. HA-WBRT using IMPT is a promising treatment to prevent cognitive decline and alopecia.

Irradiation Fields and Doses in Glioblastoma Multiforme: Are Current Standards Adequate?

2001 ◽  
Vol 87 (2) ◽  
pp. 85-90 ◽  
Author(s):  
Michele Reni ◽  
Cesare Cozzarini ◽  
Maria Grazia Panucci ◽  
Giovanni Luca Ceresoli ◽  
Andrés José María Ferreri ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
Performance Status ◽  
Phase Iii ◽  
Control Group ◽  
Whole Brain ◽  
Female Ratio ◽  
Brain Irradiation ◽  
Impact On Survival ◽  
Prospective Trials ◽  
The Impact

Aims and background The optimum conventional radiotherapy in glioblastoma multiforme patients has not been clearly defined by prospective trials. To better characterize a standard radiotherapy in glioblastoma multiforme, the impact on survival of different fields and doses was analyzed in a retrospective single center series. Methods One hundred and forty-seven patients with glioblastoma multiforme, submitted to biopsy only (n = 15), subtotal (n = 48) or total resection (n = 82) and who completed the planned postsurgical radiotherapy, were considered. The median age was 57 years, the male/female ratio 1.5/1, and the performance status ≥70 in 76%. Whole brain irradiation, followed by a boost to partial brain, was used in 75 cases with a whole brain dose of 44–50 Gy (median, 46) and a partial brain dose of 56–70 Gy (median, 60 Gy). Partial brain irradiation alone was used in 72 patients with a dose of 56–70 Gy (median, 61 Gy). Ninety-eight patients received 56–60 Gy (median, 59 Gy) to partial brain whereas 49 patients received 61–70 Gy (median, 63 Gy). Results There was an almost significantly longer survival in patients irradiated to the partial brain alone with respect to those also receiving whole brain radiotherapy (P = 0.056). Doses <60 Gy significantly prolonged survival (P = 0.006). Multivariate analysis confirmed that the impact on survival of radiation dose was independent of age, performance status, extent of surgery, field of irradiation and the use of chemotherapy. The extent of irradiation field was not independently related to improved survival. Conclusions Our retrospective findings suggest that we reflect on the adequacy of the current standard irradiation parameters. Well-designed prospective trials are necessary to standardize the radiotherapy control group in patients with glioblastoma multiforme to be compared in phase III trials with innovative therapeutic approaches.

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