SU-E-T-417: The Impact of Normal Tissue Constraints On PTV Dose Homogeneity for Intensity Modulated Radiotherapy (IMRT), Volume Modulated Arc Therapy (VMAT) and Tomotherapy

2014 ◽  
Vol 41 (6Part18) ◽  
pp. 322-322
Author(s):  
J Peng ◽  
D McDonald ◽  
M Ashenafi ◽  
A Ellis ◽  
K Vanek
Keyword(s):  
Normal Tissue ◽  
Intensity Modulated Radiotherapy ◽  
Intensity Modulated ◽  
Arc Therapy ◽  
Dose Homogeneity ◽  
The Impact

scholarly journals Volumetric Modulated Arc Radiotherapy for Early Stage Non-Small-Cell Lung Carcinoma: Is It Better Than the Conventional Static Beam Intensity Modulated Radiotherapy?

2014 ◽  
Vol 2014 ◽  
pp. 1-5
Author(s):  
Vincent Wing Cheung Wu ◽  
Man In Pun ◽  
Cho Pan Lam ◽  
To Wing Mok ◽  
Wah Wai Mok
Keyword(s):  
Early Stage ◽  
Small Cell Lung Carcinoma ◽  
Volumetric Modulated Arc Therapy ◽  
Intensity Modulated Radiotherapy ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Intensity Modulated ◽  
Significant Difference ◽  
Arc Therapy

This study compared the performance of volumetric modulated arc therapy (VMAT) techniques: single arc volumetric modulated arc therapy (SA-VMAT) and double arc volumetric modulated arc therapy (DA-VMAT) with the static beam conventional intensity modulated radiotherapy (C-IMRT) for non-small-cell lung carcinoma (NSCLC). Twelve stage I and II NSCLC patients were recruited and their planning CT with contoured planning target volume (PTV) and organs at risk (OARs) was used for planning. Using the same dose constraints and planning objectives, the C-IMRT, SA-VMAT, and DA-VMAT plans were optimized. C-IMRT consisted of 7 static beams, while SA-VMAT and DA-VMAT plans consisted of one and two full gantry rotations, respectively. No significant difference was found among the three techniques in target homogeneity and conformity. Mean lung dose in C-IMRT plan was significantly lower than that in DA-VMAT plan P=0.04. The ability of OAR sparing was similar among the three techniques, with no significant difference in V20, V10, or V5 of normal lungs, spinal cord, and heart. Less MUs were required in SA-VMAT and DA-VMAT. Besides, SA-VMAT required the shortest beam on time among the three techniques. In treatment of early stage NSCLC, no significant dosimetric superiority was shown by the VMAT techniques over C-IMRT and DA-VMAT over SA-VMAT.

Randomized Controlled Trial of Intensity-Modulated Radiotherapy for Early Breast Cancer: 5-Year Results Confirm Superior Overall Cosmesis

2013 ◽  
Vol 31 (36) ◽  
pp. 4488-4495 ◽  
Author(s):  
Mukesh B. Mukesh ◽  
Gillian C. Barnett ◽  
Jennifer S. Wilkinson ◽  
Anne M. Moody ◽  
Charles Wilson ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Breast Tissue ◽  
Controlled Trial ◽  
Univariate Analysis ◽  
Intensity Modulated Radiotherapy ◽  
Tumor Bed ◽  
Intensity Modulated ◽  
Randomized Controlled ◽  
Dose Homogeneity ◽  
Breast Imrt

Purpose There are few randomized controlled trial data to confirm that improved homogeneity with simple intensity-modulated radiotherapy (IMRT) decreases late breast tissue toxicity. The Cambridge Breast IMRT trial investigated this hypothesis, and the 5-year results are reported. Patients and Methods Standard tangential plans of 1,145 trial patients were analyzed; 815 patients had inhomogeneous plans (≥ 2 cm3 receiving 107% of prescribed dose: 40 Gy in 15 fractions over 3 weeks) and were randomly assigned to standard radiotherapy (RT) or replanned with simple IMRT; 330 patients with satisfactory dose homogeneity were treated with standard RT and underwent the same follow-up as the randomly assigned patients. Breast tissue toxicities were assessed at 5 years using validated methods: photographic assessment (overall cosmesis and breast shrinkage compared with baseline pre-RT photographs) and clinical assessment (telangiectasia, induration, edema, and pigmentation). Comparisons between different groups were analyzed using polychotomous logistic regression. Results On univariate analysis, compared with standard RT, fewer patients in the simple IMRT group developed suboptimal overall cosmesis (odds ratio [OR], 0.68; 95% CI, 0.48 to 0.96; P = .027) and skin telangiectasia (OR, 0.58; 95% CI, 0.36 to 0.92; P = .021). No evidence of difference was seen for breast shrinkage, breast edema, tumor bed induration, or pigmentation. The benefit of IMRT was maintained on multivariate analysis for both overall cosmesis (P = .038) and skin telangiectasia (P = .031). Conclusion Improved dose homogeneity with simple IMRT translates into superior overall cosmesis and reduces the risk of skin telangiectasia. These results are practice changing and should encourage centers still using two-dimensional RT to implement simple breast IMRT.

scholarly journals The normal tissue sparing obtained with simultaneous treatment of pelvic lymph nodes and bladder using intensity-modulated radiotherapy

2009 ◽  
Vol 48 (2) ◽  
pp. 238-244 ◽  
Author(s):  
Jimmi Søndergaard ◽  
Morten Høyer ◽  
Jørgen B. Petersen ◽  
Pauliina Wright ◽  
Cai Grau ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Normal Tissue ◽  
Intensity Modulated Radiotherapy ◽  
Simultaneous Treatment ◽  
Pelvic Lymph Nodes ◽  
Intensity Modulated ◽  
Normal Tissue Sparing ◽  
Tissue Sparing
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