SU-D-BRE-06: Modeling the Dosimetric Effects of Volumetric and Layer-Based Repainting Strategies in Spot Scanning Proton Treatment Plans

2014 ◽  
Vol 41 (6Part3) ◽  
pp. 112-113
Author(s):  
J E Johnson ◽  
C Beltran ◽  
M G Herman ◽  
J J Kruse
Keyword(s):  
Spot Scanning ◽  
Proton Treatment ◽  
Treatment Plans

scholarly journals Clinical Implementation of a Proton Dose Verification System Utilizing a GPU Accelerated Monte Carlo Engine

2016 ◽  
Vol 3 (2) ◽  
pp. 312-319 ◽  
Author(s):  
Chris Beltran ◽  
H. Wan Chan Tseung ◽  
Kurt E. Augustine ◽  
Martin Bues ◽  
Daniel W. Mundy ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Dose Calculation ◽  
Planning System ◽  
Treatment Planning System ◽  
Dose Verification ◽  
Spot Scanning ◽  
Proton Treatment ◽  
Treatment Plans ◽  
Biological Dose ◽  
Monte Carlo Dose Calculation

Abstract Purpose: To develop a clinical infrastructure that allows for routine Monte Carlo dose calculation verification of spot scanning proton treatment plans and includes a simple biological model to aid in normal tissue protection. Materials and Methods: A graphical processing unit accelerated Monte Carlo dose engine was used as the calculation engine for dose verification on spot scanning proton plans. An infrastructure was built around this engine that allows for seamless exporting of treatment plans from the treatment planning system and importing of dose distribution from the Monte Carlo calculation via DICOM (digital imaging and communications in medicine). An easy-to-use Web-based interface was developed so that the application could be run from any computer. In addition to the standard relative biological effectiveness = 1.1 for proton therapy, a simple linear equation dependent on dose-weighted linear energy transfer was included. This was used to help detect possible high biological dose in critical structures. Results: More than 270 patients were treated at our proton center in the first year of operation. Because most plans underwent multiple iterations before final approval, more than 1000 plans have been run through the system from multiple users with minimal downtime. The average time from plan export to importing of the Monte Carlo doses was less than 15 minutes. Treatment plans have been modified based on the nominal Monte Carlo dose or the biological dose. Conclusion: Monte Carlo dose calculation verification of spot scanning proton treatment plans is feasible in a clinical environment. The 3-dimensional dose verification, particularly near heterogeneities, has resulted in plan modifications. The biological dose data provides actionable feedback for end of range effects, especially in pediatric patients.

scholarly journals OC-0552: Skin-NTCP driven optimization for breast proton treatment plans

2016 ◽  
Vol 119 ◽  
pp. S264-S265
Author(s):  
L. Cella ◽  
F. Tommasino ◽  
V. D'Avino ◽  
G. Palma ◽  
F. Pastore ◽  
...  
Keyword(s):  
Proton Treatment ◽  
Treatment Plans

Optimal Spot Scanning Treatment Plans for Centrally Located Infant Brain Tumors

2012 ◽  
Vol 84 (3) ◽  
pp. S643-S644
Author(s):  
J. Peacock ◽  
N.N. Laack ◽  
C. Nwachukwu ◽  
C.J. Beltran
Keyword(s):  
Brain Tumors ◽  
Spot Scanning ◽  
Treatment Plans ◽  
Infant Brain

Optimizing mini-ridge filter thickness to reduce proton treatment times in a spot-scanning synchrotron system

2014 ◽  
Vol 41 (6Part1) ◽  
pp. 061713 ◽  
Author(s):  
Lorraine Courneyea ◽  
Chris Beltran ◽  
Hok Seum Wan Chan Tseung ◽  
Juan Yu ◽  
Michael G. Herman
Keyword(s):  
Spot Scanning ◽  
Proton Treatment ◽  
Filter Thickness ◽  
Ridge Filter

scholarly journals Feasibility study: Spot-scanning Proton Arc therapy (SPArc) for left-sided breast irradiation

2020 ◽  
Author(s):  
Sheng Chang ◽  
Gang Liu ◽  
Lewei Zhao ◽  
Joshua T Dilworth ◽  
Weili Zheng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Proton Therapy ◽  
Normal Tissue ◽  
Breast Irradiation ◽  
Ipsilateral Lung ◽  
Intensity Modulated Proton Therapy ◽  
Intensity Modulated ◽  
Spot Scanning ◽  
Proton Treatment ◽  
Beam Delivery

Abstract Background This study investigated the feasibility and potential clinical benefit of utilizing a new proton treatment technique: Spot-scanning Proton Arc (SPArc) therapy for left-sided breast cancer irradiation to further reduce radiation dose to healthy tissue and mitigate the probability of normal tissue complications compared to conventional Intensity Modulated Proton Therapy(IMPT). Methods Eight patients diagnosed with left-sided breast cancer and treated with breast-preserving surgery followed by whole breast irradiation without regional nodal irradiation were included in this retrospective planning. Two proton treatment plans were generated for each patient: vertical intensity-modulated proton therapy used for clinical treatment (vIMPT, gantry angle 10°-30°) and SPArc for comparison purpose. Both SPArc and vIMPT plans were optimized using the robust optimization of ± 3.5% range and 5 mm setup uncertainties. Root-mean-square deviation dose (RMSD) volume histograms were used for plan robustness evaluation. All dosimetric results were evaluated based on dose-volume histograms (DVH), and the interplay effect was evaluated based on the accumulation of single-fraction 4D dynamic dose on CT50. The treatment beam delivery time was simulated based on a gantry rotation with energy-layer-switching-time (ELST) from 0.2 to 5 s. Results The average D1 to the heart and LAD were reduced to 53.63 cGy and 82.25 cGy compared with vIMPT 110.38 cGy (p = 0.001) and 170.38 cGy (p = 0.001), respectively. The average V5Gy and V20Gy of ipsilateral lung was reduced to 16.77% and 3.07% compared to vIMPT 25.56% (p = 0.001) and 4.68% (p = 0.003). Skin3mm mean and maximum dose was reduced to 3999.38 cGy and 4395.63 cGy compared to vIMPT 4104.25 cGy (p = 0.039) and 4411.63 cGy (p = 0.043), respectively. A significant relative risk reduction (RNTCP = NTCPSPArc / NTCPvIMPT) for organs at risk (OARs) was obtained with SPArc ranging from 0.61 to 0.86 depending on the clinical endpoint. The RMSD Volume Histogram(RVH) analysis shows SPArc provided better plan robustness in OARs sparing, including the heart, LAD, ipsilateral lung, and skin. The average estimated treatment beam delivery times were comparable to vIMPT plans when the ELST is about 0.5 s. Conclusion SPArc technique can further reduce dose delivered to OARs and the probability of normal tissue complications in patients treated for left-sided breast cancer.

scholarly journals Feasibility study: Spot-scanning Proton Arc therapy (SPArc) for left-sided whole breast radiotherapy

2020 ◽  
Author(s):  
Sheng Chang ◽  
Gang Liu ◽  
Lewei Zhao ◽  
Joshua T Dilworth ◽  
Weili Zheng ◽  
...  
Keyword(s):  
Proton Therapy ◽  
Normal Tissue ◽  
Breast Radiotherapy ◽  
Ipsilateral Lung ◽  
Intensity Modulated Proton Therapy ◽  
Intensity Modulated ◽  
Spot Scanning ◽  
Whole Breast Radiotherapy ◽  
Proton Treatment ◽  
Beam Delivery

Abstract Background : This study investigated the feasibility and potential clinical benefit of utilizing a new proton treatment technique: Spot-scanning Proton Arc (SPArc) therapy for left-sided whole breast radiotherapy (WBRT) to further reduce radiation dose to healthy tissue and mitigate the probability of normal tissue complications compared to conventional Intensity Modulated Proton Therapy (IMPT). Methods : Eight patients diagnosed with left-sided breast cancer and treated with breast-preserving surgery followed by whole breast irradiation without regional nodal irradiation were included in this retrospective planning. Two proton treatment plans were generated for each patient: vertical intensity-modulated proton therapy used for clinical treatment (vIMPT, gantry angle 10°-30°) and SPArc for comparison purpose. Both SPArc and vIMPT plans were optimized using the robust optimization of ±3.5% range and 5mm setup uncertainties. Root-mean-square deviation dose (RMSD) volume histogram s were used for plan robustness evaluation. All dosimetric results were evaluated based on dose-volume histograms (DVH), and the interplay effect was evaluated based on the accumulation of single-fraction 4D dynamic dose on CT50. The treatment beam delivery time was simulated based on a gantry rotation with energy-layer-switching-time (ELST) from 0.2 to 5s. Results: The average D1 to the heart and LAD were reduced to 53.63cGy and 82.25cGy compared with vIMPT 110.38cGy (p = 0.001) and 170.38cGy (p = 0.001), respectively. The average V5Gy and V20Gy of ipsilateral lung was reduced to 16.77% and 3.07% compared to vIMPT 25.56% (p = 0.001) and 4.68% (p = 0.003). Skin3mm mean and maximum dose were reduced to 3999.38cGy and 4395.63cGy compared to vIMPT 4104.25cGy (p=0.039) and 4411.63cGy (p=0.043), respectively. A significant relative risk reduction (RNTCP = NTCP SPArc / NTCP vIMPT ) for organs at risk (OARs) was obtained with SPArc ranging from 0.61 to 0.86 depending on the clinical endpoint. The RMSD Volume Histogram (RVH) analysis shows SPArc provided better plan robustness in OARs sparing, including the heart, LAD, ipsilateral lung, and skin. The average estimated treatment beam delivery times were comparable to vIMPT plans when the ELST is about 0.5s. Conclusion: SPArc technique can further reduce dose delivered to OARs and the probability of normal tissue complications in patient treated for left-sided WBRT.

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