SU-E-T-292: In-Vivo Blood Oxygen Measurements Via Interstitial Fiber Optic Probe and Photoacoustic Imaging

2013 ◽  
Vol 40 (6Part15) ◽  
pp. 271-271
Author(s):  
D Campos ◽  
A Torres ◽  
M Lakshman ◽  
M Kissick ◽  
R Kimple ◽  
...  
Keyword(s):  
Fiber Optic ◽  
Photoacoustic Imaging ◽  
Blood Oxygen ◽  
Fiber Optic Probe ◽  
Optic Probe ◽  
Oxygen Measurements

A Chemometric Analysis for Evaluation of Early-Stage Cartilage Degradation by Infrared Fiber-Optic Probe Spectroscopy

2005 ◽  
Vol 59 (12) ◽  
pp. 1527-1533 ◽  
Author(s):  
Guiyang Li ◽  
Mary Thomson ◽  
Edward Dicarlo ◽  
Xu Yang ◽  
Bryan Nestor ◽  
...  
Keyword(s):  
Fiber Optic ◽  
Early Stage ◽  
Cartilage Degradation ◽  
Fiber Optic Probe ◽  
Replacement Surgery ◽  
Multiple Regions ◽  
Grading Scale ◽  
Optic Probe ◽  
Probe Spectroscopy

In vivo identification of early-stage cartilage degradation could positively impact disease progression in osteoarthritis, but to date remains a challenge. The primary goal of this study was to develop an infrared fiber-optic probe (IFOP) chemometric method using partial least squares (PLS1) to objectively determine the degree of cartilage degradation. Arthritic human tibial plateaus ( N = 61) were obtained during knee replacement surgery and analyzed by IFOP. IFOP data were collected from multiple regions of each specimen and the cartilage graded according to the Collins Visual Grading Scale of 0, 1, 2, or 3. These grades correspond to cartilage morphology that displayed normal, swelling or softening, superficially slight fibrillation, and deeper fibrillation or serious fibrillation, respectively. The model focused on detecting early cartilage degradation and therefore utilized data from grades 0, 1, and 2. The best PLS1 calibration utilized the spectral range 1733–984 cm−1, and independent validation of the model utilizing 206 spectra to create a model and 105 independent test spectra resulted in a correlation between the predicted and actual Collins grade of R2 = 0.8228 with a standard error of prediction of 0.258 with a PLS1 rank of 15 PLS factors. A preliminary PLS1 calibration that utilized a cross-validation technique to investigate the possibility of correlation with histological tissue grade (33 spectra from 18 tissues) resulted in R2 = 0.8408 using only eight PLS factors, a very encouraging outcome. Thus, the groundwork for use of IFOP-based chemometric determination of early cartilage degradation has been established.

scholarly journals Modelling, Design and Validation of Spatially Resolved Reflectance Based Fiber Optic Probe for Epithelial Precancer Diagnostics

2020 ◽  
Vol 10 (24) ◽  
pp. 8836
Author(s):  
Pankaj Singh ◽  
Prabodh Pandey ◽  
Shivam Shukla ◽  
Naren Naik ◽  
Asima Pradhan
Keyword(s):  
Fiber Optic ◽  
Numerical Study ◽  
Fiber Optic Probe ◽  
Scattering Coefficients ◽  
Spatially Resolved ◽  
Fiber Optic Probes ◽  
Diagnosis Of Cancer ◽  
Optic Probe ◽  
In Vivo Diagnosis

Fiber-optic probes are imperative for in-vivo diagnosis of cancer. Depending on the access to a diseased organ and the mutations one aims to sense, the probe designs vary. We carry out a detailed numerical study of the efficacy of the common probe geometries for epithelial cancer characterization based on spatially resolved reflectance data. As per the outcomes of this comparative study, a probe has been manufactured and using Monte Carlo look up table based inversion scheme, the absorption and scattering coefficients of the epithelium mimicking top layer have been recovered from noisy synthetic as well as experimental data.

Fiber optic probe for polarized reflectance spectroscopy in vivo: Design and performance

2002 ◽  
Vol 7 (3) ◽  
pp. 388 ◽  
Author(s):  
Alexey Myakov ◽  
Linda Nieman ◽  
Lorenz Wicky ◽  
Urs Utzinger ◽  
Rebecca Richards-Kortum ◽  
...  
Keyword(s):  
Fiber Optic ◽  
Reflectance Spectroscopy ◽  
Fiber Optic Probe ◽  
Optic Probe ◽  
And Performance ◽  
Polarized Reflectance

Hollow fiber optic probe for in vivo Raman measurement

2006 ◽  
Author(s):  
Takashi Katagiri ◽  
Yusuke Hattori ◽  
Yuichi Komachi ◽  
Yuji Matsuura ◽  
Hideo Tashiro ◽  
...  
Keyword(s):  
Hollow Fiber ◽  
Fiber Optic ◽  
Fiber Optic Probe ◽  
Raman Measurement ◽  
Optic Probe

scholarly journals THE VARIATIONS OF WATER IN HUMAN TISSUE UNDER CERTAIN COMPRESSION: STUDIED WITH DIFFUSE REFLECTANCE SPECTROSCOPY

2013 ◽  
Vol 06 (01) ◽  
pp. 1350005 ◽  
Author(s):  
CHENXI LI ◽  
JINGYING JIANG ◽  
KEXIN XU
Keyword(s):  
Human Tissue ◽  
Fiber Optic ◽  
Reflectance Spectrum ◽  
Diffuse Reflectance Spectroscopy ◽  
Pressure Effects ◽  
Water Volume ◽  
Fiber Optic Probe ◽  
Optic Probe

The reflectance spectrum has been widely adopted to extract diagnosis information of human tissue because it possesses the advantages of noninvasive and rapidity. The external pressure brought by fiber optic probe may influence the accuracy of measurement. In this paper, a systematic study is focused on the effects of probe pressure on intrinsic changes of water and scattering particles in tissue. According to the biphasic nonlinear mixture model, the pressure modulated reflectance spectrum of both in vitro and in vivo tissue is measured and processed with second-derivation. The results indicate that the variations of bulk and bonded water in tissue have a nonlinear relationship with the pressure. Differences in tissue structure and morphology contribute to site-specific probe pressure effects. Then the finite element (FEM) and Monte Carlo (MC) method is employed to simulate the deformation and reflectance spectrum variations of tissue before and after compression. The simulation results show that as the pressure of fiber optic probe applied to the detected skin increased to 80 kPa, the effective photon proportion form dermis decreases significantly from 86% to 76%. Future designs might benefit from the research of change of water volume inside the tissue to mitigate the pressure applied to skin.

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