SU-E-T-253: Treatment Planning and Dose Delivery of Photon Radiation Therapy of Cardiac Arrhythmias for Isolated Perfused Porcine Hearts

2013 ◽  
Vol 40 (6Part14) ◽  
pp. 262-262
Author(s):  
L Song ◽  
H Lehmann ◽  
J Cusma ◽  
J Misiri ◽  
K Parker ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Treatment Planning ◽  
Cardiac Arrhythmias ◽  
Photon Radiation ◽  
Dose Delivery

Treatment planning intercomparison for spinal chordomas using intensity-modulated photon radiation therapy (IMRT) and carbon ions

2003 ◽  
Vol 48 (16) ◽  
pp. 2617-2631 ◽  
Author(s):  
D Schulz-Ertner ◽  
A Nikoghosyan ◽  
B Didinger ◽  
C P Karger ◽  
O J kel ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Treatment Planning ◽  
Photon Radiation ◽  
Carbon Ions ◽  
Intensity Modulated

P13.21 PET-based dose painting radiation therapy strategy in a glioblastoma rat model using the small animal radiation research platform

2021 ◽  
Vol 23 (Supplement_2) ◽  
pp. ii37-ii37
Author(s):  
S Donche ◽  
J Verhoeven ◽  
C Bouckaert ◽  
B Descamps ◽  
R Raedt ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Treatment Planning ◽  
Rat Model ◽  
Planning Process ◽  
Radiation Treatment ◽  
Dose Delivery ◽  
Fet Pet ◽  
Irradiation System ◽  
Preclinical Treatment ◽  
Radiation Research

Abstract BACKGROUND Previously, a rat glioblastoma model to mimic chemo-radiation treatment of human glioblastoma in the clinic was established. Similarly to the clinic, CT and MRI were combined during the treatment planning process. PET imaging was subsequently added which allowed us to implement sub-volume boosting using a micro-irradiation system. However, combining three imaging modalities (CT, MRI and PET) using a micro-irradiation system, proved to be labour intensive because multimodal imaging, treatment planning and dose delivery have to be completed sequentially in the preclinical setting. MATERIAL AND METHODS Two different methodologies were compared in silico for performing preclinical [18F]FET PET based radiation therapy (20 Gy based on MRI, 8 Gy boost based on PET) based on three different cases. Method 1 is based on the previously published methods1,2. However, the process is automated using an in-house developed MATLAB code. Method 2 consists of a more sophisticated method where a series of isocenters and jaw dimensions for the motorised variable collimator were determined based on the [18F]FET PET uptake. Both methods were evaluated by means of the dose volume histograms (DVH) and Q-volume histograms. RESULTS The setup parameters for both methods were calculated. The DVHs for method 2 are systematically closer to the ideal dose distribution compared to method 1. These findings are confirmed by the D90 and D50 values which are considerably lower for method 1. When observing the Q-factor, method 2 always results in dose distributions that are closer to the dose objectives (method 1: 0.141±0.046; method 2: 0.064±0.011). CONCLUSION The described novel method to optimize the preclinical treatment planning process has many advantages in terms of dose delivery, time efficiency and variability, when compared to the previously used methods1,2. These improvements are important to narrow the gap between clinical and preclinical radiation research and for the development of new therapeutics and/or radiation therapy procedures for glioblastoma. 1. Bolcaen, J., Descamps, B., Boterberg, T., Vanhove, C. & Goethals, I. PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator. J. Vis. Exp. 1–10 (2017) doi:10.3791/56601. 2. Verhoeven, J. et al. Technical feasibility of [18F]FET and [18F]FAZA PET guided radiotherapy in a F98 glioblastoma rat model. Radiat. Oncol. 14, (2019).

scholarly journals Measurement with electret ion chambers of absorbed dose outside the treated volume, during external-photon radiation therapy

2021 ◽  
pp. 15-15
Author(s):  
Alexandros Clouvas ◽  
Anna Makridou ◽  
Michalis Chatzimarkou
Keyword(s):  
Radiation Therapy ◽  
Treatment Planning ◽  
Absorbed Dose ◽  
Planning System ◽  
Photon Radiation ◽  
Treatment Planning System ◽  
Low Doses ◽  
Prescription Dose ◽  
Ion Chambers ◽  
Leakage Radiation

The capabilities of electret ion chambers to measure non-target absorbed dose for distances greater than 20 cm from the irradiated volume during radiotherapy treatment was investigated for the first time. During radiotherapy, nontarget doses can be classified as one of three approximate dose levels: high doses, intermediate doses and low doses. Low doses (<5 % of the prescription dose) are not generally considered during treatment planning, due to the fact that is difficult to measure, characterize, or model them in the planning system. In this work were performed measurements with electret ion chambers of absorbed dose outside the treated volume (<5 % of the prescription dose), during external photon radiation therapy in an Elekta Infinity Linear Accelerator of ?Theagenio? Cancer Hospital of Thessaloniki, Greece. The absorbed dose values for distances greater than 20 cm from the irradiated volume varied from 0.3 to 17 mGy which corresponds to 0.01% up to 0.6% of the prescription dose (2660 mGy). Near the irradiation volume the absorbed dose values were greater than the upper detection limit of the electret ion chambers (threshold 40 mGy). The results are compared with the calculated ones by the Monaco Treatment Planning System (Elekta Monaco 5.11.03). In the non-target radiation region where Monaco Treatment Planning System calculates rather precisely (within uncertainties of less than 10%) the absorbed dose, measured and calculated doses are the same within experimental uncertainties. On the contrary, when leakage radiation becomes the dominant source of out-of-field dose the differences are up to 31%.

Radiation Therapy Dose Delivery

2003 ◽  
Vol 42 (2) ◽  
pp. 1-1 ◽  
Author(s):  
Karl-axel Johansson ◽  
S&#x000F6;ren Mattsson ◽  
Anders Brahme ◽  
J&#x000F6;rgen Carlsson ◽  
Bj&#x000F6;rn Zackrisson ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Dose Delivery
Sign in / Sign up

Export Citation Format

Share Document