scholarly journals The effect of flattening filter free delivery on endothelial dose enhancement with gold nanoparticles

2013 ◽  
Vol 40 (3) ◽  
pp. 031706 ◽  
Author(s):  
Alexandre Detappe ◽  
Panagiotis Tsiamas ◽  
Wilfred Ngwa ◽  
Piotr Zygmanski ◽  
Mike Makrigiorgos ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Dose Enhancement ◽  
Flattening Filter Free ◽  
Flattening Filter

scholarly journals The effect of flattening filter free delivery on endothelial dose enhancement with gold nanoparticles

2013 ◽  
Vol 29 ◽  
pp. e41
Author(s):  
A. Detappe ◽  
P. Tsiamas ◽  
W. Ngwa ◽  
P. Zygmanski ◽  
M. Makrigiorgos ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Dose Enhancement ◽  
Flattening Filter Free ◽  
Flattening Filter

scholarly journals Depth Dose Enhancement on Flattening-Filter-Free Photon Beam: A Monte Carlo Study in Nanoparticle-Enhanced Radiotherapy

2020 ◽  
Vol 10 (20) ◽  
pp. 7052
Author(s):  
James C. L. Chow
Keyword(s):  
Monte Carlo ◽  
Monte Carlo Study ◽  
Photon Beam ◽  
Depth Range ◽  
Photon Beams ◽  
Dose Enhancement ◽  
Au Nps ◽  
Depth Dose ◽  
Flattening Filter Free ◽  
Flattening Filter

The aim of this study is to investigate the variations of depth dose enhancement (DDE) on different nanoparticle (NP) variables, when using the flattening-filter-free (FFF) photon beam in nanoparticle-enhanced radiotherapy. Monte Carlo simulation under a macroscopic approach was used to determine the DDE ratio (DDER) with variables of NP material (gold (Au) and iron (III) oxide (Fe2O3)), NP concentration (3–40 mg/mL) and photon beam (10 MV flattening-filter (FF) and 10 MV FFF). It is found that Au NPs had a higher DDER than Fe2O3 NPs, when the depths were shallower than 6 and 8 cm for the 10 MV FF and 10 MV FFF photon beams, respectively. However, in a deeper depth range of 10–20 cm, DDER for the Au NPs was lower than Fe2O3 NPs mainly due to the beam attenuation and photon energy distribution. It is concluded that DDER for the Au NPs and Fe2O3 NPs decreased with an increase of depth in the range of 10–20 cm, with rate of decrease depending on the NP material, NP concentration and the use of FF in the photon beam.

Dosimetry and Radioenhancement Comparison of Gold Nanoparticles in Kilovoltage and Megavoltage Radiotherapy using MAGAT Polymer Gel Dosimeter

2019 ◽  
Vol 9 (2Apr) ◽  
Author(s):  
S Farahani ◽  
N Riyahi Alam ◽  
S Haghgoo ◽  
M Khoobi ◽  
Gh Geraily ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
3D Visualization ◽  
Energy Levels ◽  
Polymer Gel ◽  
External Radiotherapy ◽  
Dose Enhancement ◽  
Internal Radiotherapy ◽  
Boost Radiotherapy

Background: Numerous unique characteristics of the nanosized gold, including high atomic number, low toxicity, and high biocompatibility make it one of the most appropriate nanostructures to boost radiotherapy efficacy. Many in-vivo and in-vitro investigations have indicated that gold nanoparticles (AuNPs) can significantly increase tumor injuries in low kilovoltage radiotherapy. While deep-lying tumors require much higher energy levels with greater penetration power, and investigations carried out in megavoltage energy range show contradictory results.Objective: In this study, we quantitatively assess and compare dose enhancement factors (DEFs) obtained through AuNPs under radiation of Cobalt-60 source (1.25MeV) versus Iridium-192 source (0.380 KeV) using MAGAT gel dosimeter.Material and Methods: MAGAT polymer gel in both pure and combined with 0.2 mM AuNPs was synthesized. In order to quantify the effect of energy on DEF, irradiation was carried out by Co-60 external radiotherapy and Ir-192 internal radiotherapy. Finally, readings of irradiated and non-irradiated gels were performed by MR imaging.Result: The radiation-induced R2 (1/T2) changes of the gel tubes doped with AuNPs compared to control samples, upon irradiation of beams released by Ir-192 source showed a significant dose enhancement (15.31% ±0.30) relative to the Co-60 external radiotherapy (5.85% ±0.14).Conclusion: This preliminary study suggests the feasibility of using AuNPs in radiation therapy (RT), especially in low-energy sources of brachytherapy. In addition, MAGAT polymer gel, as a powerful dosimeter, could be used for 3D visualization of radiation dose distribution of AuNPs in radiotherapy.

scholarly journals Initial Clinical Experience Treating Patients with Breast Cancer on a 6-MV Flattening-Filter-Free O-Ring Linear Accelerator

2019 ◽  
Vol 4 (4) ◽  
pp. 571-578 ◽  
Author(s):  
Andrew R. Barsky ◽  
Fionnbarr O'Grady ◽  
Christopher Kennedy ◽  
Neil K. Taunk ◽  
Lei Dong ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Experience ◽  
Linear Accelerator ◽  
Flattening Filter Free ◽  
Flattening Filter ◽  
Initial Clinical Experience

Photon dose at the maze entrance door: The comparison of flattening filter and flattening filter free working modes

2018 ◽  
Vol 49 ◽  
pp. 1-4
Author(s):  
Á.Á. Tóth ◽  
L.D. Dragojlović ◽  
N.V. Ignjatov ◽  
M. Krmar
Keyword(s):  
Flattening Filter Free ◽  
Photon Dose ◽  
Entrance Door ◽  
Flattening Filter
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