scholarly journals Ultrasound GLCM texture analysis of radiation-induced parotid-gland injury in head-and-neck cancer radiotherapy: An in vivo study of late toxicity

2012 ◽  
Vol 39 (9) ◽  
pp. 5732-5739 ◽  
Author(s):  
Xiaofeng Yang ◽  
Srini Tridandapani ◽  
Jonathan J. Beitler ◽  
David S. Yu ◽  
Emi J. Yoshida ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Parotid Gland ◽  
Head And Neck ◽  
Texture Analysis ◽  
Neck Cancer ◽  
Late Toxicity ◽  
In Vivo Study ◽  
Cancer Radiotherapy ◽  
Radiation Induced

PO-0955 ULTRASOUND HISTOGRAM ASSESSMENT OF PAROTID-GLAND INJURY FOLLOWING HEAD-AND-NECK CANCER RADIOTHERAPY

2012 ◽  
Vol 103 ◽  
pp. S376
Author(s):  
X. Yang ◽  
S. Tridandapani ◽  
J. Beitler ◽  
D. Yu ◽  
E. Yoshida ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Parotid Gland ◽  
Head And Neck ◽  
Neck Cancer ◽  
Cancer Radiotherapy

Targeted gold nanoparticles enable molecular CT imaging of head and neck cancer: An in vivo study

2019 ◽  
Vol 114 ◽  
pp. 105554 ◽  
Author(s):  
Sara Khademi ◽  
Saeed Sarkar ◽  
Ali Shakeri-Zadeh ◽  
Neda Attaran ◽  
Sharmin Kharrazi ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Ct Imaging ◽  
In Vivo Study

scholarly journals The kinetics of γ-H2AX during radiotherapy of head and neck cancer potentially allow for prediction of severe mucositis

2020 ◽  
Vol 54 (1) ◽  
pp. 96-102
Author(s):  
Joanna Kazmierska ◽  
Wojciech Barczak ◽  
Tomasz Winiecki ◽  
Łukasz Łuczewski ◽  
Magdalena Marciniak ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Peripheral Blood Lymphocytes ◽  
Significant Difference ◽  
Radiation Induced ◽  
The Difference ◽  
Kinetics Of ◽  
Severe Mucositis

AbstractBackgroundThe aim of the study was to evaluate the changes in γ-H2AX expression in peripheral blood lymphocytes (PBL) according to severity of radiation-induced mucositis.Patients and methodFifty patients with head and neck cancer treated with radiotherapy (RT) or chemoradiation were included in the study. Blood samples were collected before treatment to measure baseline γ-H2AX levels. Second sample was taken 45 minutes after the first RT fraction and then once a week, 45 min after irradiation. In patients treated with chemoradiation the blood sample was taken the day after chemotherapy. Mucositis was evaluated once a week and reported according to CTCAE v4 and RTOG/EORTC scales. PBL were analyzed with flow cytometry and level of H2AX phosphorylation at every time point was evaluated.ResultsIn 35 patients mild to moderate (grade 1–2) mucositis was observed and 15 patients developed severe (grade 3) mucositis. No cases of grade 4 mucositis were observed. The difference in baseline levels of γ-H2AX between groups with mild and severe mucositis was statistically insignificant (p = 0.25). The statistically significant difference in γ-H2AX level was observed in week 7 of treatment (p = 0.01). No significant differences in γ-H2AX level were found neither between group treated with concomitant chemoradiation or RT alone neither between groups with and without common comorbidities. In the analysis of the kinetics of γ-H2AX during treatment, a statistically significant difference (p = 0.0088) between groups with mild and severe mucositis was observed. After fourth week of treatment levels of γ-H2AX decreased significantly in the group with severe mucositis and increased in patients with mild side effects. The observed difference was not caused by the decrease in peripheral lymphocyte count, which was similar in both groups.ConclusionsPresented results indicate that severity of radiation-induced mucositis does not correlate directly with γ-H2AX levels measured in vivo in PBL. Prediction of mucositis grade based on γ-H2AX level is not yet possible, either before treatment or early during treatment, but preliminary results, indicating significant differences in γ-H2AX kinetics between groups, encourage further studies.

scholarly journals Radiation-induced Parotid Gland Atrophy in Patients with Head and Neck Cancer After Carbon-ion Radiotherapy

2016 ◽  
Vol 36 (10) ◽  
pp. 5403-5408 ◽  
Author(s):  
TAKAMICHI MORIKAWA ◽  
MASASHI KOTO ◽  
AZUSA HASEGAWA ◽  
RYO TAKAGI ◽  
AKIRA FUJIKAWA ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Parotid Gland ◽  
Head And Neck ◽  
Neck Cancer ◽  
Carbon Ion Radiotherapy ◽  
Carbon Ion ◽  
Radiation Induced ◽  
Gland Atrophy

A Novel In Vivo Protocol for Molecular Study of Radiation-Induced Fibrosis in Head and Neck Cancer Patients

2015 ◽  
Vol 125 (3) ◽  
pp. 228-234 ◽  
Author(s):  
Gintas P. Krisciunas ◽  
Michael Platt ◽  
Maria Trojanowska ◽  
Gregory A. Grillone ◽  
Paul C. Haines ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Molecular Study ◽  
Radiation Induced
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