TH-E-218-10: Feasibility Demonstration and Initial Construction of an Integrated Carbon Nanotube Micro-CT System for Compact Microbeam Radiation Therapy Image Guidance

2012 ◽  
Vol 39 (6Part31) ◽  
pp. 4019-4019 ◽  
Author(s):  
L Zhang ◽  
M Hadsell ◽  
L Burk ◽  
J Zhang ◽  
G Cao ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Carbon Nanotube ◽  
Image Guidance ◽  
Micro Ct ◽  
Microbeam Radiation Therapy ◽  
Ct System

scholarly journals Pilot study for compact microbeam radiation therapy using a carbon nanotube field emission micro-CT scanner

2014 ◽  
Vol 41 (6Part1) ◽  
pp. 061710 ◽  
Author(s):  
Mike Hadsell ◽  
Guohua Cao ◽  
Jian Zhang ◽  
Laurel Burk ◽  
Torsten Schreiber ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Carbon Nanotube ◽  
Pilot Study ◽  
Field Emission ◽  
Micro Ct ◽  
Ct Scanner ◽  
Microbeam Radiation Therapy

TH-C-220-01: Pilot Study for the Development of Clinical Microbeam Radiation Therapy Using a Carbon Nanotube Field Emission Micro-CT Scanner

2011 ◽  
Vol 38 (6Part35) ◽  
pp. 3862-3862
Author(s):  
M Hadsell ◽  
J Zhang ◽  
G Cao ◽  
E Schreiber ◽  
J Lu ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Carbon Nanotube ◽  
Pilot Study ◽  
Field Emission ◽  
Micro Ct ◽  
Ct Scanner ◽  
Microbeam Radiation Therapy

WE-D-303A-01: Feasibility Study of Microbeam Radiation Therapy Using a Carbon Nanotube Field Emission Based Electron Microbeam Irradiator

2009 ◽  
Vol 36 (6Part25) ◽  
pp. 2775-2775
Author(s):  
J Zhang ◽  
D Bordelon ◽  
J Snider ◽  
E Schreiber ◽  
A Cox ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Carbon Nanotube ◽  
Field Emission ◽  
Feasibility Study ◽  
Microbeam Radiation Therapy

scholarly journals A first generation compact microbeam radiation therapy system based on carbon nanotube X-ray technology

2013 ◽  
Vol 103 (18) ◽  
pp. 183505 ◽  
Author(s):  
M. Hadsell ◽  
J. Zhang ◽  
P. Laganis ◽  
F. Sprenger ◽  
J. Shan ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Carbon Nanotube ◽  
First Generation ◽  
X Ray ◽  
Microbeam Radiation Therapy

Fixed gantry tomosynthesis system for radiation therapy image guidance based on a multiple source x-ray tube with carbon nanotube cathodes

2009 ◽  
Vol 36 (5) ◽  
pp. 1624-1636 ◽  
Author(s):  
Jonathan S. Maltz ◽  
Frank Sprenger ◽  
Jens Fuerst ◽  
Ajay Paidi ◽  
Franz Fadler ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Carbon Nanotube ◽  
Image Guidance ◽  
Multiple Source ◽  
X Ray

scholarly journals Incorporating Clinical Imaging into the Delivery of Microbeam Radiation Therapy

2021 ◽  
Vol 11 (19) ◽  
pp. 9101
Author(s):  
Jason Paino ◽  
Micah Barnes ◽  
Elette Engels ◽  
Jeremy Davis ◽  
Susanna Guatelli ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Image Guidance ◽  
Radiation Treatment ◽  
Small Animal ◽  
Conventional Radiography ◽  
Patient Specific ◽  
Microbeam Radiation Therapy ◽  
Tumour Bearing ◽  
Treatment Margins

Synchrotron microbeam radiation therapy is a promising pre-clinical radiation treatment modality; however, it comes with many technical challenges. This study describes the image guidance protocol used for Australia’s first long-term pre-clinical MRT treatment of rats bearing 9L gliosarcoma tumours. The protocol utilises existing infrastructure available at the Australian Synchrotron and the adjoining Monash Biomedical Imaging facility. The protocol is designed and optimised to treat small animals utilising high-resolution clinical CT for patient specific tumour identification, coupled with conventional radiography, using the recently developed SyncMRT program for image guidance. Dosimetry performed in small animal phantoms shows patient dose is comparable to standard clinical doses, with a CT associated dose of less than 1.39cGy and a planar radiograh dose of less than 0.03cGy. Experimental validation of alignment accuracy with radiographic film demonstrates end to end accuracy of less than ±0.34mm in anatomical phantoms. Histological analysis of tumour-bearing rats treated with microbeam radiation therapy verifies that tumours are targeted well within applied treatment margins. To date, this technique has been used to treat 35 tumour-bearing rats.

Tolerance of Normal Rabbit Facial Bones and Teeth to Synchrotron X-Ray Microbeam Irradiation

2021 ◽  
Author(s):  
Jean Albert Laissue ◽  
Sébastien Barré ◽  
Stefan Bartzsch ◽  
Hans Blattmann ◽  
Audrey M. Bouchet ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Soft Tissues ◽  
Ex Vivo ◽  
Radiation Toxicity ◽  
Micro Ct ◽  
Facial Bones ◽  
X Ray ◽  
Microbeam Radiation Therapy ◽  
Entrance Dose ◽  
One Year

Microbeam radiation therapy, an alternative radiosurgical treatment under preclinical investigation, aims to safely treat muzzle tumors in pet animals. This will require data on the largely unknown radiation toxicity of microbeam arrays for bones and teeth. To this end, the muzzle of six young adult New Zealand rabbits was irradiated by a lateral array of microplanar beamlets with peak entrance doses of 200, 330 or 500 Gy. The muzzles were examined 431 days postirradiation by computed microtomographic imaging (micro-CT) ex vivo, and extensive histopathology. The boundaries of the radiation field were identified histologically by microbeam tracks in cartilage and other tissues. There was no radionecrosis of facial bones in any rabbit. Conversely, normal incisor teeth exposed to peak entrance doses of 330 Gy or 500 Gy developed marked caries-like damage, whereas the incisors of the two rabbits exposed to 200 Gy remained unscathed. A single, unidirectional array of microbeams with a peak entrance dose ≤200 Gy (valley dose14 Gy) did not damage normal bone, teeth and soft tissues of the muzzle of normal rabbits longer than one year after irradiation. Because of that, Microbeam radiation therapy of muzzle tumors in pet animals is unlikely to cause sizeable damage to normal teeth, bone and soft tissues, if a single array as used here delivers a limited entrance dose of 200 Gy and a valley dose of ≤14 Gy.

scholarly journals Detection of Aortic Arch Calcification in Apolipoprotein E‐Null Mice Using Carbon Nanotube–Based Micro‐CT System

2013 ◽  
Vol 2 (1) ◽  
Author(s):  
John M. S. Wait ◽  
Hirofumi Tomita ◽  
Laurel M. Burk ◽  
Jianping Lu ◽  
Otto Z. Zhou ◽  
...  
Keyword(s):  
Carbon Nanotube ◽  
Apolipoprotein E ◽  
Aortic Arch ◽  
Micro Ct ◽  
Ct System ◽  
Aortic Arch Calcification
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