TH-E-BRA-09: Radiation Induced Current Effects on MR Images from an Integrated Linac-MR System

2012 ◽  
Vol 39 (6Part31) ◽  
pp. 4013-4013
Author(s):  
B Burke ◽  
K Wachowicz ◽  
B Fallone ◽  
S Rathee
2012 ◽  
Vol 39 (10) ◽  
pp. 6139-6147 ◽  
Author(s):  
Ben Burke ◽  
K. Wachowicz ◽  
B. G. Fallone ◽  
Satyapal Rathee

Author(s):  
A. Gommlich ◽  
F. Raschke ◽  
J. Petr ◽  
A. Seidlitz ◽  
C. Jentsch ◽  
...  

Abstract Objective Brain atrophy has the potential to become a biomarker for severity of radiation-induced side-effects. Particularly brain tumour patients can show great MRI signal changes over time caused by e.g. oedema, tumour progress or necrosis. The goal of this study was to investigate if such changes affect the segmentation accuracy of normal appearing brain and thus influence longitudinal volumetric measurements. Materials and methods T1-weighted MR images of 52 glioblastoma patients with unilateral tumours acquired before and three months after the end of radio(chemo)therapy were analysed. GM and WM volumes in the contralateral hemisphere were compared between segmenting the whole brain (full) and the contralateral hemisphere only (cl) with SPM and FSL. Relative GM and WM volumes were compared using paired t tests and correlated with the corresponding mean dose in GM and WM, respectively. Results Mean GM atrophy was significantly higher for full segmentation compared to cl segmentation when using SPM (mean ± std: ΔVGM,full = − 3.1% ± 3.7%, ΔVGM,cl = − 1.6% ± 2.7%; p < 0.001, d = 0.62). GM atrophy was significantly correlated with the mean GM dose with the SPM cl segmentation (r = − 0.4, p = 0.004), FSL full segmentation (r = − 0.4, p = 0.004) and FSL cl segmentation (r = -0.35, p = 0.012) but not with the SPM full segmentation (r = − 0.23, p = 0.1). Conclusions For accurate normal tissue volume measurements in brain tumour patients using SPM, abnormal tissue needs to be masked prior to segmentation, however, this is not necessary when using FSL.


1983 ◽  
Vol 54 (5) ◽  
pp. 366-369
Author(s):  
A. P. Elokhin ◽  
N. I. Filatov ◽  
S. N. Makeev

2018 ◽  
Vol 45 (4) ◽  
pp. 1518-1528 ◽  
Author(s):  
Elisa Scalco ◽  
Tiziana Rancati ◽  
Ileana Pirovano ◽  
Alfonso Mastropietro ◽  
Federica Palorini ◽  
...  

1982 ◽  
Vol 17 (10) ◽  
pp. 3052-3056
Author(s):  
Y. Nakase ◽  
I. Kuriyama ◽  
T. Takahashi ◽  
S. Isshiki

Author(s):  
Mark Robert Keezer ◽  
Rolando Del Maestro

The case of a 51-year-old man diagnosed with two acquired cavernous hemangiomas 17 years after cranial irradiation for a cerebellar astrocytoma is reported. A review of 84 cases of radiation-induced cavernous hemangiomas found in the literature is presented. In this series the mean age at the time of irradiation (±SD) was 10.4 ± 2.0 years (median = 8 years), while the mean time to cavernous hemangioma diagnosis (±SD) was 10.3 ± 1.9 years (median = 8 years). Time to cavernous hemangioma diagnosis was found to be inversely related to radiation dose. Hemorrhage from radiation-induced cavernous hemangiomas was found in 40.0% of patients, with an incidence of 3.9% per patient year. An inverse trend was identified between radiation dose and symptomatic presentation, cavernous hemangioma hemorrhage or surgical resection. This review of radiation-induced cavernous hemangiomas confirms that both younger patients and those who received a larger dose of radiation are at increased risk of radiation-induced cavernous hemangiomas. Our results suggest that, based on an assessment of CT or MR images, there may be an increased risk of hemorrhage when comparing radiation-induced to congenital cavernous hemangiomas. Increasing radiation doses appear to stabilize these lesions, decreasing the risk of a symptomatic presentation, cavernous hemangioma hemorrhage and surgical intervention.


1992 ◽  
Vol 72 (1) ◽  
pp. 99-102 ◽  
Author(s):  
V. I. ARKHIPOV ◽  
IRINA A. PEROVA ◽  
A. I. RUDENKO

2000 ◽  
Vol 142 (7) ◽  
pp. 801-804 ◽  
Author(s):  
S. Suzuki ◽  
S. Nishio ◽  
K. Takata ◽  
T. Morioka ◽  
M. Fukui

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