TH-E-BRB-04: Dose Response of EBT2 Film Modeled as a Bimolecular Reaction

2012 ◽  
Vol 39 (6Part31) ◽  
pp. 4009-4009
Author(s):  
L Perles ◽  
D Mirkovic ◽  
A Anand ◽  
U Titt ◽  
R Mohan
2010 ◽  
Vol 37 (5) ◽  
pp. 1942-1947 ◽  
Author(s):  
Bijan Arjomandy ◽  
Ramesh Tailor ◽  
Aman Anand ◽  
Narayan Sahoo ◽  
Michael Gillin ◽  
...  

2011 ◽  
Vol 38 (6Part12) ◽  
pp. 3510-3511
Author(s):  
S Tenn ◽  
D Ruan ◽  
T Dou ◽  
D Low

2011 ◽  
Vol 38 (6Part13) ◽  
pp. 3524-3525
Author(s):  
S Park ◽  
S Kang ◽  
K Cheong ◽  
T Hwang ◽  
M Lee ◽  
...  

2013 ◽  
Vol 40 (6Part10) ◽  
pp. 212-212
Author(s):  
W Chen ◽  
X Di ◽  
S Wang ◽  
B Wang ◽  
X Bai ◽  
...  

Author(s):  
Enrique Castano ◽  
Ruben D Flores-Saaib

Several reports over the last few years have documented the dose–response curve for steroid hormone induction of gene transcription as a modulated property of a given receptor–agonist complex that varies with the changing concentration of a variety of factors including: homologous receptor, co-activators, co-repressors and selected co-factors. In each report, the dose–response curves are sigmoidal and show an excellent fit with the curve generated by Michaelis–Menten kinetics. In addition, even the overall function of human oestrogen receptors (hERs) can show a similar graph for the determination of sex versus oestrogen compounds in reptiles. Thus, the kinetic properties of the simple bimolecular reaction of A+B→C appear, surprisingly, to be sufficient to describe the dose–response curve of the multi-step process of steroid-regulated gene induction that involves several molecules. Any advance in explaining why the dose–response curve for steroid-regulated gene expression is sigmoidal would assist in understanding what parameters are key factors of the dose–response curve and can benefit in the design of new oestrogenic substances. We have constructed and analysed a multi-step model of hER-induced gene transcription that explains the multiple forms of a simple dose–response curve in an in vitro transcription system.


2010 ◽  
Vol 37 (6Part21) ◽  
pp. 3265-3265 ◽  
Author(s):  
A Anand ◽  
B Arjomandy ◽  
R Tailor ◽  
N Sahoo ◽  
M Gillin

1963 ◽  
Vol 45 (2) ◽  
pp. 209-214 ◽  
Author(s):  
Donald H. Hanscom ◽  
Armand Littman ◽  
Jack V. Pinto

1999 ◽  
Vol 1 ◽  
pp. S47-S47
Author(s):  
N PAYNE ◽  
R GROCOTTMASON ◽  
A IONESCU ◽  
B SJOBERG ◽  
I SANDBLOM ◽  
...  

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