SU-E-I-73: Gray Matter Atrophy and White Matter Tract Abnormalities by Voxel Wise Correlation Analysis in Patients with Alzheimer's Disease

2012 ◽  
Vol 39 (6Part5) ◽  
pp. 3641-3641
Author(s):  
R Juh ◽  
T Suh ◽  
S Kim
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Correlation Analysis ◽  
Gray Matter ◽  
White Matter Tract ◽  
Gray Matter Atrophy

IC-P-111: Cerebral hypoperfusion, gray-matter atrophy, and white-matter pathology in incipient Alzheimer's disease

2015 ◽  
Vol 11 (7S_Part_2) ◽  
pp. P76-P77 ◽  
Author(s):  
Miranka Wirth ◽  
Alexa Pichet Binette ◽  
Peter Brunecker ◽  
Theresa Köbe ◽  
Veronica A. Witte ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Gray Matter ◽  
Cerebral Hypoperfusion ◽  
Gray Matter Atrophy ◽  
White Matter Pathology

scholarly journals Topographic patterns of white matter hyperintensities are associated with multimodal neuroimaging biomarkers of Alzheimer’s disease

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Malo Gaubert ◽  
Catharina Lange ◽  
Antoine Garnier-Crussard ◽  
Theresa Köbe ◽  
Salma Bougacha ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Glucose Metabolism ◽  
Corpus Callosum ◽  
Gray Matter ◽  
Fdg Pet ◽  
White Matter Hyperintensities ◽  
Gray Matter Volume ◽  
Matter Volume

Abstract Background White matter hyperintensities (WMH) are frequently found in Alzheimer’s disease (AD). Commonly considered as a marker of cerebrovascular disease, regional WMH may be related to pathological hallmarks of AD, including beta-amyloid (Aβ) plaques and neurodegeneration. The aim of this study was to examine the regional distribution of WMH associated with Aβ burden, glucose hypometabolism, and gray matter volume reduction. Methods In a total of 155 participants (IMAP+ cohort) across the cognitive continuum from normal cognition to AD dementia, FLAIR MRI, AV45-PET, FDG-PET, and T1 MRI were acquired. WMH were automatically segmented from FLAIR images. Mean levels of neocortical Aβ deposition (AV45-PET), temporo-parietal glucose metabolism (FDG-PET), and medial-temporal gray matter volume (GMV) were extracted from processed images using established AD meta-signature templates. Associations between AD brain biomarkers and WMH, as assessed in region-of-interest and voxel-wise, were examined, adjusting for age, sex, education, and systolic blood pressure. Results There were no significant associations between global Aβ burden and region-specific WMH. Voxel-wise WMH in the splenium of the corpus callosum correlated with greater Aβ deposition at a more liberal threshold. Region- and voxel-based WMH in the posterior corpus callosum, along with parietal, occipital, and frontal areas, were associated with lower temporo-parietal glucose metabolism. Similarly, lower medial-temporal GMV correlated with WMH in the posterior corpus callosum in addition to parietal, occipital, and fontal areas. Conclusions This study demonstrates that local white matter damage is correlated with multimodal brain biomarkers of AD. Our results highlight modality-specific topographic patterns of WMH, which converged in the posterior white matter. Overall, these cross-sectional findings corroborate associations of regional WMH with AD-typical Aß deposition and neurodegeneration.

scholarly journals Patterns of Cerebellar Gray Matter Atrophy Across Alzheimer’s Disease Progression

2018 ◽  
Vol 12 ◽  
Author(s):  
Sofia Toniolo ◽  
Laura Serra ◽  
Giusy Olivito ◽  
Camillo Marra ◽  
Marco Bozzali ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Progression ◽  
Gray Matter ◽  
Gray Matter Atrophy ◽  
Cerebellar Gray Matter

scholarly journals White matter tract integrity in aging and Alzheimer's disease

2009 ◽  
Vol 30 (4) ◽  
pp. 1051-1059 ◽  
Author(s):  
Jessica S. Damoiseaux ◽  
Stephen M. Smith ◽  
Menno P. Witter ◽  
Ernesto J. Sanz-Arigita ◽  
Frederik Barkhof ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
White Matter Tract
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