Monte Carlo-based treatment planning system calculation engine for microbeam radiation therapy

2012 ◽  
Vol 39 (5) ◽  
pp. 2829-2838 ◽  
Author(s):  
I. Martínez-Rovira ◽  
J. Sempau ◽  
Y. Prezado
Keyword(s):  
Monte Carlo ◽  
Radiation Therapy ◽  
Treatment Planning ◽  
Planning System ◽  
Treatment Planning System ◽  
Microbeam Radiation Therapy ◽  
System Calculation

scholarly journals Validation of a Monte Carlo simulation for Microbeam Radiation Therapy on the Imaging and Medical Beamline at the Australian Synchrotron

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Andrew Dipuglia ◽  
Matthew Cameron ◽  
Jeremy A. Davis ◽  
Iwan M. Cornelius ◽  
Andrew W. Stevenson ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Monte Carlo ◽  
Radiation Therapy ◽  
Planning System ◽  
Treatment Planning System ◽  
Photon Flux ◽  
X Rays ◽  
Dose Distributions ◽  
Microbeam Radiation Therapy ◽  
Independent Verification

AbstractMicrobeam Radiation Therapy (MRT) is an emerging cancer treatment modality characterised by the use of high-intensity synchrotron-generated x-rays, spatially fractionated by a multi-slit collimator (MSC), to ablate target tumours. The implementation of an accurate treatment planning system, coupled with simulation tools that allow for independent verification of calculated dose distributions are required to ensure optimal treatment outcomes via reliable dose delivery. In this article we present data from the first Geant4 Monte Carlo radiation transport model of the Imaging and Medical Beamline at the Australian Synchrotron. We have developed the model for use as an independent verification tool for experiments in one of three MRT delivery rooms and therefore compare simulation results with equivalent experimental data. The normalised x-ray spectra produced by the Geant4 model and a previously validated analytical model, SPEC, showed very good agreement using wiggler magnetic field strengths of 2 and 3 T. However, the validity of absolute photon flux at the plane of the Phase Space File (PSF) for a fixed number of simulated electrons was unable to be established. This work shows a possible limitation of the G4SynchrotronRadiation process to model synchrotron radiation when using a variable magnetic field. To account for this limitation, experimentally derived normalisation factors for each wiggler field strength determined under reference conditions were implemented. Experimentally measured broadbeam and microbeam dose distributions within a Gammex RMI457 Solid Water® phantom were compared to simulated distributions generated by the Geant4 model. Simulated and measured broadbeam dose distributions agreed within 3% for all investigated configurations and measured depths. Agreement between the simulated and measured microbeam dose distributions agreed within 5% for all investigated configurations and measured depths.

scholarly journals A benchmarking method to evaluate the accuracy of a commercial proton monte carlo pencil beam scanning treatment planning system

2017 ◽  
Vol 18 (2) ◽  
pp. 44-49 ◽  
Author(s):  
Liyong Lin ◽  
Sheng Huang ◽  
Minglei Kang ◽  
Petri Hiltunen ◽  
Reynald Vanderstraeten ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Treatment Planning ◽  
Planning System ◽  
Treatment Planning System ◽  
Pencil Beam ◽  
Beam Scanning ◽  
Pencil Beam Scanning

scholarly journals Evaluation of a treatment planning system developed for clinical boron neutron capture therapy and validation against an independent Monte Carlo dose calculation system

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Naonori Hu ◽  
Hiroki Tanaka ◽  
Ryo Kakino ◽  
Syuushi Yoshikawa ◽  
Mamoru Miyao ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Treatment Planning ◽  
Neutron Capture ◽  
Gamma Ray ◽  
Dose Calculation ◽  
Planning System ◽  
Treatment Planning System ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture ◽  
Monte Carlo Dose Calculation

AbstractBoron neutron capture therapy (BNCT) for the treatment of unresectable, locally advanced, and recurrent carcinoma of the head and neck cancer has been approved by the Japanese government for reimbursement under the national health insurance as of June 2020. A new treatment planning system for clinical BNCT has been developed by Sumitomo Heavy Industries, Ltd. (Sumitomo), NeuCure® Dose Engine. To safely implement this system for clinical use, the simulated neutron flux and gamma ray dose rate inside a water phantom was compared against experimental measurements. Furthermore, to validate and verify the new planning system, the dose distribution inside an anthropomorphic head phantom was compared against a BNCT treatment planning system SERA and an in-house developed Monte Carlo dose calculation program. The simulated results closely matched the experimental results, within 5% for the thermal neutron flux and 10% for the gamma ray dose rate. The dose distribution inside the head phantom closely matched with SERA and the in-house developed dose calculation program, within 3% for the tumour and a difference of 0.3 Gyw for the brain.

Sign in / Sign up

Export Citation Format

Share Document