TU-G-BRA-02: Monte Carlo Simulation of the Effects of Radiation Quality and Oxygen Concentration on Clustered DNA Lesions Formed by Ionizing Radiation

2011 ◽  
Vol 38 (6Part30) ◽  
pp. 3777-3777
Author(s):  
RD Stewart
Keyword(s):  
Monte Carlo Simulation ◽  
Monte Carlo ◽  
Ionizing Radiation ◽  
Oxygen Concentration ◽  
Dna Lesions ◽  
Radiation Quality ◽  
Effects Of Radiation

A Theoretical Approach to Modeling Ionizing Radiation Migration and Dose in Aquatic Environments Using Monte Carlo Simulation

2003 ◽  
Vol 9 (6) ◽  
pp. 1493-1504
Author(s):  
E. N. Avrorin ◽  
A. G. Tsvetokhin ◽  
A. I. Xenofontov ◽  
E. I. Kourbatova ◽  
J. L. Regens ◽  
...  
Keyword(s):  
Monte Carlo Simulation ◽  
Monte Carlo ◽  
Ionizing Radiation ◽  
Theoretical Approach ◽  
Aquatic Environments

Effects of Radiation Quality and Oxygen on Clustered DNA Lesions and Cell Death

2011 ◽  
Vol 176 (5) ◽  
pp. 587-602 ◽  
Author(s):  
Robert D. Stewart ◽  
Victor K. Yu ◽  
Alexandros G. Georgakilas ◽  
Constantinos Koumenis ◽  
Joo Han Park ◽  
...  
Keyword(s):  
Cell Death ◽  
Dna Lesions ◽  
Radiation Quality ◽  
Effects Of Radiation

scholarly journals Monte Carlo Simulation-Based Calculations of Complex DNA Damage for Incidents of Environmental Ionizing Radiation Exposure

2021 ◽  
Vol 11 (19) ◽  
pp. 8985
Author(s):  
Spyridon A. Kalospyros ◽  
Violeta Gika ◽  
Zacharenia Nikitaki ◽  
Antigoni Kalamara ◽  
Ioanna Kyriakou ◽  
...  
Keyword(s):  
Dna Damage ◽  
Monte Carlo ◽  
Ionizing Radiation ◽  
Mammalian Cells ◽  
Absorbed Dose ◽  
Dna Lesions ◽  
Lifetime Cancer Risk ◽  
Exposed Population ◽  
Exposed Individual ◽  
Risk Of Cancer

In this paper, we present a useful Monte Carlo (MC)-based methodology that can be utilized to calculate the absorbed dose and the initial levels of complex DNA damage (such as double strand breaks-DSBs) in the case of an environmental ionizing radiation (IR) exposure incident (REI) i.e., a nuclear accident. Our objective is to assess the doses and complex DNA damage by isolating only one component of the total radiation released in the environment after a REI that will affect the health of the exposed individual. More specifically, the radiation emitted by radionuclide 137Cs in the ground (under the individual’s feet). We use a merging of the Monte Carlo N-Particle Transport code (MCNP) with the Monte Carlo Damage Simulation (MCDS) code. The DNA lesions have been estimated through simulations for different surface activities of a 137Cs ground-based γ radiation source. The energy spectrum of the emitted secondary electrons and the absorbed dose in typical mammalian cells have been calculated using the MCNP code, and then these data are used as an input in the MCDS code for the estimation of critical DNA damage levels and types. As a realistic application, the calculated dose is also used to assess the Excess Lifetime Cancer Risk (ELCR) for eight hypothetical individuals, living in different zones around the Chernobyl Nuclear Power Plant, exposed to different time periods at the days of the accident in 1986. We conclude that any exposition of an individual in the near zone of Chernobyl increases the risk of cancer at a moderate to high grade, connected also with the induction of complex DNA damage by radiation. Generally, our methodology has proven to be useful for assessing γ rays-induced complex DNA damage levels of the exposed population, in the case of a REI and for better understanding the long-term health effects of exposure of the population to IR.

Monte Carlo Simulation of the Oxygen Effect in DNA Damage Induction by Ionizing Radiation

2018 ◽  
Vol 190 (3) ◽  
pp. 248 ◽  
Author(s):  
Jake C. Forster ◽  
Michael J. J. Douglass ◽  
Wendy M. Phillips ◽  
Eva Bezak
Keyword(s):  
Dna Damage ◽  
Monte Carlo Simulation ◽  
Monte Carlo ◽  
Ionizing Radiation ◽  
Oxygen Effect
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