SU-E-T-766: Verification of Volumetric Modulated Arc Therapy Plans with Independent Three Dimensional Dose Computation Algorithm

2011 ◽  
Vol 38 (6Part22) ◽  
pp. 3667-3667 ◽  
Author(s):  
M Kathirvel ◽  
V Shanmuga Subramanian ◽  
G Arun ◽  
S Thirumalai swamy ◽  
K Ramalingam ◽  
...  
Author(s):  
Nguyen Tuong Pham

Mục tiêu: Đánh giá vai trò của cộng hưởng từ (Magnetic Resonance Imaging - MRI) trong mô phỏng lập kế hoạch xạ trị cho bệnh lý u não tại Bệnh viện Trung Ương Huế, đánh giá sự tối ưu, lợi ích của vai trò MRI, các giá trị liều lượng mà u và các cơ quan lành nhận được. Đối tượng và phương pháp: Nghiên cứu 38 bệnh nhân u não được chỉ định xạ trị có chụp cắt lớp vi tính (Computed Tomography-CT) 16 lát cắt Philips và cộng hưởng từ(MRI) 1.5 Tesla Philips tại Trung tâm Ung bướu - Bệnh viện Trung Ương Huế từ tháng 01/2018-07/2019. Lập kế hoạch xạ trị gia tốc bằng phần mềm XiO 5.10 đối với kỹ thuật xạ trị 3D-CRT (Three Dimensional - Conformal Radiation Therapy), và phần mềm Monaco 5.11 đối với các kỹ thuật xạ trị hình cung điều biến liều theo thể tích khối u (Volumetric Modulated Arc Therapy-VMAT), Xạ phẫu gồm SRS và SRT (Stereotactic radiosurgery, Stereotactic radiotherapy). Chụp Cone beam CT kiểm tra trước khi điều trị bởi thiết bị hướng dẫn hình ảnh XVI. Điều trị trên máy gia tốc AXESSE (Elekta). Kết quả và bàn luận: 38 bệnh nhân có khối u ở não (u nguyên phát và u di căn) MRI giúp phát hiện thêm các tổn thương 39,5% và 55,3% phát hiện rõ ranh giới u, tất cả những thương tổn u mà CT rất khó phân biệt với mô lành và tổn thương phù não. Kết luận: Ứng dụng hình ảnh MRI trong mô phỏng lập kế hoạch xạ trị gia tốc cho các bệnh lý u não giúp phát hiện và xác định kích thước, thể tích u tốt hơn so với CT mô phỏng. Từ đó sẽ làm thay đổi kế hoạch xạ trị đem lại kết quả điều trị tốt hơn và cải thiện chất lượng sống tốt hơn cho bệnh nhân


2021 ◽  
Vol 59 (1) ◽  
pp. 25-30
Author(s):  
A. Rakhimov ◽  
M. Zekebayev ◽  
A. Kuatbek ◽  
V. Dyachkov

An optimal choice of radiation therapy method is the main prerequisite for successful completion of treatment. Continuous analysis of radiation therapy methods’ advantages and comparing their parameters and dose load in typical cases will increase the treatment efficacy and reduce the unavoidable load on critical organs. The purpose was to check the plans of treatment by volumetric modulated arc therapy (VMAT) and three-dimensional conformal radiation therapy (3D-CRT) methods, make their comparison and identify the advantages using an example of a treatment design for a patient treated at the Daily Radiotherapy Hospital of the Kazakh Institute of Oncology and Radiology (Almaty, Kazakhstan). Results: The presented illustrations of the process planning and the numerical analysis of the dose load on critical organs show VMAT advantages for radiation therapy of salivary gland cancer: optimal coverage, sparing load on critical organs and healthy tissues, gradient decay at the borders of the neoplasm. Conclusion: The variability of radiation therapy methods ensures the most acceptable coverage that keeps the dose load within international standards’ ranges. Mastering these methods will improve the effectiveness of radiation therapy for various cancer cases


Cancers ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 401 ◽  
Author(s):  
Sebastian Adeberg ◽  
Semi Harrabi ◽  
Nina Bougatf ◽  
Vivek Verma ◽  
Paul Windisch ◽  
...  

(1) Background: Selecting patients that will benefit the most from proton radiotherapy (PRT) is of major importance. This study sought to assess dose reductions to numerous organs-at-risk (OARs) with PRT, as compared to three-dimensional conformal radiotherapy (3DCRT) and volumetric-modulated arc therapy (VMAT), as a function of tumor location. (2) Materials/Methods: Patients with intracranial neoplasms (all treated with PRT) were stratified into five location-based groups (frontal, suprasellar, temporal, parietal, posterior cranial fossa; n = 10 per group). Each patient was re-planned for 3DCRT and intensity-modulated radiotherapy (IMRT) using similar methodology, including the originally planned target and organ-at-risk (OAR) dose constraints. (3) Results: In parietal tumors, PRT showed the most pronounced dose reductions. PRT lowered doses to nearly every OAR, most notably the optical system and several contralateral structures (subventricular zone, thalamus, hippocampus). For frontal lobe cases, the greatest relative dose reductions in mean dose (Dmean) with PRT were to the infratentorial normal brain, contralateral hippocampus, brainstem, pituitary gland and contralateral optic nerve. For suprasellar lesions, PRT afforded the greatest relative Dmean reductions to the infratentorial brain, supratentorial brain, and the whole brain. Similar results could be observed in temporal and posterior cranial fossa disease. (4) Conclusions: The effectiveness and degree of PRT dose-sparing to various OARs depends on intracranial tumor location. These data will help to refine selection of patients receiving PRT, cost-effectiveness, and future clinical toxicity assessment.


2020 ◽  
Vol 9 (12) ◽  
pp. 3884
Author(s):  
Yi-Chi Liu ◽  
Hung-Ming Chang ◽  
Hsin-Hon Lin ◽  
Chia-Chun Lu ◽  
Lu-Han Lai

This study aimed to compare different types of right breast cancer radiotherapy planning techniques and to estimate the whole-body effective doses and the critical organ absorbed doses. The three planning techniques are intensity-modulated radiotherapy (IMRT), volumetric modulated arc therapy (VMAT; two methods) and hybrid 3D-CRT/IMRT (three-dimensional conformal radiotherapy/intensity-modulated radiotherapy). The VMAT technique includes two methods to deliver a dose: non-continuous partial arc and continuous partial arc. A thermoluminescent dosimeter (TLD) is placed in the RANDO phantom to estimate the organ absorbed dose. Each planning technique applies 50.4 Gy prescription dose and treats critical organs, including the lung and heart. Dose-volume histogram was used to show the planning target volume (V95%), homogeneity index (HI), conformity index (CI), and other optimized indices. The estimation of whole-body effective dose was based on the International Commission on Radiation Protection (ICRP) Publication 60 and 103. The results were as follows: Continuous partial arc and non-continuous partial arc showed the best CI and HI. The heart absorbed doses in the continuous partial arc and hybrid 3D-CRT/IMRT were 0.07 ± 0.01% and 0% (V5% and V10%, respectively). The mean dose of the heart was lowest in hybrid 3D-CRT/IMRT (1.47 Gy ± 0.02). The dose in the left contralateral lung (V5%) was lowest in continuous partial arc (0%). The right ipsilateral lung average dose and V20% are lowest in continuous partial arc. Hybrid 3D-CRT/IMRT has the lowest mean dose to contralateral breast (organs at risk). The whole-body effective doses for ICRP-60 and ICRP-103 were highest in continuous partial arc (2.01 Sv ± 0.23 and 2.89 Sv ± 0.15, respectively). In conclusion, the use of VMAT with continuous arc has a lower risk of radiation pneumonia, while hybrid 3D-CRT/IMRT attain lower secondary malignancy risk and cardiovascular complications.


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