SU-E-T-700: PMMC - a High-Performance Monte Carlo Code for Proton Beam Dose Calculation

2011 ◽  
Vol 38 (6Part21) ◽  
pp. 3651-3651
Author(s):  
D Jacqmin
2013 ◽  
Vol 40 (6Part18) ◽  
pp. 319-319
Author(s):  
Z Tian ◽  
R Townson ◽  
Y Graves ◽  
X Jia ◽  
S Jiang

2010 ◽  
Vol 55 (13) ◽  
pp. 3917-3936 ◽  
Author(s):  
Juergen Karg ◽  
Stefan Speer ◽  
Manfred Schmidt ◽  
Reinhold Mueller

2018 ◽  
Vol 52 ◽  
pp. 184
Author(s):  
Magdalena Garbacz ◽  
Jan Gajewski ◽  
Nils Krah ◽  
Angelo Schiavi ◽  
Agata Skrzypek ◽  
...  

2006 ◽  
Vol 33 (9) ◽  
pp. 3508-3518 ◽  
Author(s):  
Haisen S. Li ◽  
H. Edwin Romeijn ◽  
James F. Dempsey

2019 ◽  
Vol 18 ◽  
pp. 153303381988718 ◽  
Author(s):  
James E. Younkin ◽  
Danairis Hernandez Morales ◽  
Jiajian Shen ◽  
Jie Shan ◽  
Martin Bues ◽  
...  

Purpose: To describe and validate the dose calculation algorithm of an independent second-dose check software for spot scanning proton delivery systems with full width at half maximum between 5 and 14 mm and with a negligible spray component. Methods: The analytical dose engine of our independent second-dose check software employs an altered pencil beam algorithm with 3 lateral Gaussian components. It was commissioned using Geant4 and validated by comparison to point dose measurements at several depths within spread-out Bragg peaks of varying ranges, modulations, and field sizes. Water equivalent distance was used to compensate for inhomogeneous geometry. Twelve patients representing different disease sites were selected for validation. Dose calculation results in water were compared to a fast Monte Carlo code and ionization chamber array measurements using dose planes and dose profiles as well as 2-dimensional–3-dimensional and 3-dimensional–3-dimensional γ-index analysis. Results in patient geometry were compared to Monte Carlo simulation using dose–volume histogram indices, 3-dimensional–3-dimensional γ-index analysis, and inpatient dose profiles. Results: Dose engine model parameters were tuned to achieve 1.5% agreement with measured point doses. The in-water γ-index passing rates for the 12 patients using 3%/2 mm criteria were 99.5% ± 0.5% compared to Monte Carlo. The average inpatient γ-index analysis passing rate compared to Monte Carlo was 95.8% ± 2.9%. The average difference in mean dose to the clinical target volume between the dose engine and Monte Carlo was −0.4% ± 1.0%. For a typical plan, dose calculation time was 2 minutes on an inexpensive workstation. Conclusions: Following our commissioning process, the analytical dose engine was validated for all treatment sites except for the lung or for calculating dose–volume histogram indices involving point doses or critical structures immediately distal to target volumes. Monte Carlo simulations are recommended for these scenarios.


Author(s):  
Ю. Кураченко ◽  
Yu. Kurachenko ◽  
Н. Санжарова ◽  
N. Sanzharova ◽  
Г. Козьмин ◽  
...  

Purpose: This work aims first to improve the reliability of absorbed dose calculation in critical organs of cattle during internal irradiation immediately after radiation accidents by a) improving the compartmental model of radionuclide metabolism in animal body; b) the use of precision computing technologies for modeling as the domain, and the actual radiation transport. In addition, the aim of the work is to determine the agreed values of the 131I critical dose in the cattle thyroid, leading to serious gland dysfunction and its follow-up destruction. Material and methods: To achieve aforecited goals, comprehensive studies were carried out to specify the parameters of the compartmental model, based on reliable experimental and theoretical data. Voxel technologies were applied for modeling the subject domain (thyroid gland and its environment). Finally, to solve the 131I radiation transport equation, the Monte Carlo code was applied, which takes into account the contribution of gamma and beta radiation source, and the contribution of the entire chain of secondary radiations in the dose calculation, up to the total energy dissipation. Results: As the main theoretical result, it is necessary to emphasize the conversion factor from the 131I activity, distributed uniformly in volume of the thyroid gland, to the average dose rate in the gland (Bq × Gy/s). This factor was calculated for both cows and calves in the selected domain configuration and thyroid morphology. The main practical result is a reliable estimation the lower bound of the absorbed dose in the thyroid, which in a short time leads to its destruction under internal 131I irradiation: ~300 Gy. Conclusion: Usage a compartmental model of the 131I metabolism with biokinetic parameters, received on the basis of reliable experimental data, and precise models of both the subject area and radiation transport for evaluation the dose in the cattle thyroid after the radiation accident allowed to obtain reliable values of the thyroid dose, adducting to its destruction at short notice.


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