SU-E-T-675: Fast Monte Carlo Simulation for Total Body Irradiation of Co-60

2011 ◽  
Vol 38 (6Part21) ◽  
pp. 3645-3645
Author(s):  
X Liu ◽  
J Rakowski ◽  
M Snyder
Keyword(s):  
Monte Carlo Simulation ◽  
Monte Carlo ◽  
Total Body Irradiation ◽  
Total Body

scholarly journals Fast Monte Carlo simulation for total body irradiation using a  60Co teletherapy unit

2013 ◽  
Vol 14 (3) ◽  
pp. 133-149 ◽  
Author(s):  
Xiaodong Liu ◽  
Danielle Lack ◽  
Joseph T. Rakowski ◽  
Cory Knill ◽  
Michael Snyder
Keyword(s):  
Monte Carlo Simulation ◽  
Monte Carlo ◽  
Total Body Irradiation ◽  
Total Body

SU-E-T-689: Semi-Automated GPU-Based Monte Carlo Dose Calculation for Total Body Irradiation

2015 ◽  
Vol 42 (6Part23) ◽  
pp. 3495-3495
Author(s):  
M Folkerts ◽  
L Ouyang ◽  
X Jia ◽  
S Jiang ◽  
X Gu
Keyword(s):  
Monte Carlo ◽  
Total Body Irradiation ◽  
Dose Calculation ◽  
Total Body ◽  
Monte Carlo Dose Calculation

Monte Carlo optimization of total body irradiation in a phantom and patient geometry

2013 ◽  
Vol 58 (8) ◽  
pp. 2461-2469 ◽  
Author(s):  
R Chakarova ◽  
K Müntzing ◽  
M Krantz ◽  
E Hedin ◽  
S Hertzman
Keyword(s):  
Monte Carlo ◽  
Total Body Irradiation ◽  
Monte Carlo Optimization ◽  
Total Body

Pharmacokinetic/Pharmacodynamic Analysis of Meropenem for the Treatment of Nosocomial Pneumonia in Intracerebral Hemorrhage Patients by Monte Carlo Simulation

2017 ◽  
Vol 51 (11) ◽  
pp. 970-975 ◽  
Author(s):  
Lingti Kong ◽  
Yan Tang ◽  
Xiaohua Zhang ◽  
Guoyu Lu ◽  
Meiling Yu ◽  
...  
Keyword(s):  
Monte Carlo Simulation ◽  
Monte Carlo ◽  
Intracerebral Hemorrhage ◽  
Nosocomial Pneumonia ◽  
High Performance ◽  
Plasma Concentrations ◽  
Volume Of Distribution ◽  
Time Profile ◽  
Dosing Regimens ◽  
Total Body

Background: Nosocomial pneumonia (NP) is a frequent complication among patients with intracerebral hemorrhage (ICH). However, there are currently no pharmacokinetic (PK) and pharmacodynamic (PD) data to guide meropenem dosing in these patients. Objective: To investigate the PK/PD properties of meropenem in these patients and whether the usual dosing regimens of meropenem (2-hour infusion, 1 g, every 8 hours) was suitable. Methods: A total of 11 patients with a diagnosis of ICH complicated with NP were selected in the emergency internal medicine and treated with a 1-g/2-hours extended infusion model. The plasma concentrations of meropenem were determined by high-performance liquid chromatography. PK parameters were estimated by plasma concentration versus time profile using WinNonlin software. The probability of target attainments (PTAs) of meropenem at different minimum inhibitory concentrations (MICs) based on percentage time that concentrations were above the minimum inhibitory concentration (%T>MIC) value were performed by Monte Carlo simulation. Results: The volume of distribution and total body clearance of meropenem were 55.55 L/kg and 22.89 L/h, respectively. Using 40%T>MIC, PTA was >90% at MICs ≤4 µg/mL. Using 80% or 100%T>MIC, PTA was >90% only at MICs ≤1 µg/mL. Conclusions: The PK/PD profile of dosing regimens tested will assist in selecting the appropriate meropenem regimens for these patients. At a target of 40%T>MIC, the usual dosing regimens can provide good coverage for pathogens with MICs of ≤4 µg/mL. However, when a higher target (80% or 100%) is desired for difficult-to-treat infections, larger doses, prolonged infusions, shorter intervals, and/or combination therapy may be required.

OC-0562 MONTE CARLO DOSE PLANNING FOR TOTAL BODY IRRADIATION

2012 ◽  
Vol 103 ◽  
pp. S225
Author(s):  
M. Krantz ◽  
K. Müntzing ◽  
R. Chakarova
Keyword(s):  
Monte Carlo ◽  
Total Body Irradiation ◽  
Dose Planning ◽  
Total Body
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